The Synthesis of a 5HT2C Receptor Agonist

This report describes the large-scale synthesis of 1 that features a Fischer indole strategy to form an advanced intermediate followed by reduction to the indoline to construct the tetracyclic core of the molecule. Resolution using dibenzoyl-d-tartaric acid affords access to a single enantiomer, fro...

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Veröffentlicht in:	Organic process research & development 2007-11, Vol.11 (6), p.985-995
Hauptverfasser:	Hobson, Lindsay A, Nugent, William A, Anderson, Stephen R, Deshmukh, Subodh S, Haley III, James J, Liu, Pingli, Magnus, Nicholas A, Sheeran, Patrick, Sherbine, James P, Stone, Benjamin R. P, Zhu, Jiang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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