A Facile and Scaleable Synthesis of ABT-239, A Benzofuranoid H3 Antagonist

A facile and scaleable synthesis of a potent and selective histamine H3 receptor antagonist, ABT-239 (1), was developed starting from commercially available 4‘-hydroxy-biphenyl-4-carbonitrile (2). The synthesis comprised four chemical steps and a salt formation step with an overall yield of 40%. A h...

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Veröffentlicht in:	Organic process research & development 2005-01, Vol.9 (1), p.45-50
Hauptverfasser:	Pu, Yu-Ming, Grieme, Timothy, Gupta, Ashok, Plata, Daniel, Bhatia, Ashok V, Cowart, Marlon, Ku, Yi-Yin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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