Equilibrium State at Supersaturated Drug Concentration Achieved by Hydroxypropyl Methylcellulose Acetate Succinate: Molecular Characterization Using 1H NMR Technique

The maintenance mechanism of the supersaturated state of poorly water-soluble drugs, glibenclamide (GLB) and chlorthalidone (CLT), in hydroxypropyl methylcellulose acetate succinate (HPMC-AS) solution was investigated at a molecular level. HPMC-AS suppressed drug crystallization from supersaturated...

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Veröffentlicht in:	Molecular pharmaceutics 2015-04, Vol.12 (4), p.1096-1104
Hauptverfasser:	Ueda, Keisuke, Higashi, Kenjirou, Yamamoto, Keiji, Moribe, Kunikazu
Format:	Artikel
Sprache:	eng ; jpn
Online-Zugang:	Volltext
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