Hybrid Ortho/Allosteric Ligands for the Adenosine A1 Receptor

Many G protein-coupled receptors (GPCRs), including the adenosine A1 receptor (A1AR), have been shown to be allosterically modulated by small molecule ligands. So far, in the absence of structural information, the exact location of the allosteric site on the A1AR is not known. We synthesized a serie...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-04, Vol.53 (8), p.3028-3037
Hauptverfasser:	Narlawar, Rajeshwar, Lane, J. Robert, Doddareddy, Munikumar, Lin, Judy, Brussee, Johannes, IJzerman, Adriaan P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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