Changes in Protein Dynamics of the DNA Repair Dioxygenase AlkB upon Binding of Fe2+ and 2-Oxoglutarate

The Escherichia coli DNA repair enzyme AlkB is a 2-oxoglutarate (2OG)-dependent Fe2+ binding dioxygenase that removes methyl lesions from DNA and RNA. To date, nine human AlkB homologues are known: ABH1 to ABH8 and the obesity-related FTO. Similar to AlkB, these homologues exert their activity on nu...

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Veröffentlicht in:	Biochemistry (Easton) 2012-04, Vol.51 (16), p.3334-3341
Hauptverfasser:	Bleijlevens, Boris, Shivarattan, Tara, van den Boom, Kim S., de Haan, Annett, van der Zwan, Gert, Simpson, Pete J., Matthews, Steve J.
Format:	Artikel
Sprache:	eng ; jpn
Online-Zugang:	Volltext
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