Applications of TiCl3 as a Diagnostic Reagent for the Detection of Nitro- and N‑Oxide-Containing Compounds as Potentially Mutagenic Impurities Using Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry

The ICH has strict guidelines for limiting the presence of potentially mutagenic impurities (PMIs) in marketed drugs. Therefore, it is important to fully characterize and quantitate all possible PMIs that could arise during the process of synthesizing and developing a drug. Two important and prevale...

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Veröffentlicht in:	Organic process research & development 2016-01, Vol.20 (1), p.59-64
Hauptverfasser:	Yang, Rong-Sheng, Beard, Adam, Sheng, Huaming, Zhang, Li-Kang, Helmy, Roy
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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