Process Development for the Manufacture of a Topical Pan-Trk Inhibitor Incorporating Decarboxylative sp2–sp3 Cross-Coupling

The development of a synthetic route toward topical pan-Trk inhibitor 1 is described as an eight-stage synthesis from available starting materials. Process improvements include the development of a decarboxylative sp2–sp3 cross-coupling which had not previously been demonstrated on scale. Parameters...

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Veröffentlicht in:	Organic process research & development 2024-12, Vol.28 (12), p.4317-4327
Hauptverfasser:	Ashwood, Michael S., Balmond, Edward I., Fengas, David, McGuffog, Jane, Moore, Jonathan, Robas, Nicola M., Stevenson, Neil G., Wise, Lisa
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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