Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor

A commercial process to manufacture sotorasib (AMG 510), a first-in-class KRASG12C inhibitor, is described. Development efforts focused on rendering a fit-for-purpose early-phase route into a viable long-term commercial process through the reduction of side reactions to improve yield and product qua...

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Veröffentlicht in:	Organic process research & development 2022-11, Vol.26 (11), p.3115-3125
Hauptverfasser:	Zhang, Liang, Griffin, Daniel J., Beaver, Matthew G., Blue, Laura E., Borths, Christopher J., Brown, Derek B., Caille, Seb, Chen, Ying, Cherney, Alan H., Cochran, Brian M., Colyer, John T., Corbett, Michael T., Correll, Tiffany L., Crockett, Richard D., Dai, Xi-Jie, Dornan, Peter K., Farrell, Robert P., Hedley, Simon J., Hsieh, Hsiao-Wu, Huang, Liang, Huggins, Seth, Liu, Min, Lovette, Michael A., Quasdorf, Kyle, Reifman, Jonathan, Robinson, Jo Anna, Sangodkar, Rahul P., Sharma, Sonika, Kumar, Srividya Sharvan, Smith, Austin G., St-Pierre, Gabrielle, Tedrow, Jason S., Thiel, Oliver R., Truong, Jonathan V., Walker, Shawn D., Wei, Carolyn S., Wilsily, Ashraf, Xie, Yong, Yang, Ning, Parsons, Andrew T.
Format:	Artikel
Sprache:	eng
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