Development of the 99mTc-Hydroxamamide Complex as a Probe Targeting Carbonic Anhydrase IX

Carbonic anhydrase IX (CA-IX) is regarded as a favorable target for in vivo imaging because of its specific expression in hypoxic regions of tumors. Hypoxia assists tumor propagation and growth and is resistant to chemotherapy and radiotherapy. Here, we designed and synthesized [99mTc]­hydroxamamide...

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Veröffentlicht in:	Molecular pharmaceutics 2019-04, Vol.16 (4), p.1489-1497
Hauptverfasser:	Iikuni, Shimpei, Tanimura, Keiichi, Watanabe, Hiroyuki, Shimizu, Yoichi, Saji, Hideo, Ono, Masahiro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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