Binding of Sulfonamide Antibiotics to CTABr Micelles Characterized Using 1H NMR Spectroscopy

Binding of Sulfonamide Antibiotics to CTABr Micelles Characterized Using 1H NMR Spectroscopy

Interactions of nine sulfonamide antibiotics (sulfadoxine, sulfathiazole, sulfamethoxazole, sulfamerazine, sulfadiazine, sulfamethazine, sulfacetamide, sulfaguanidine, and sulfanilamide) with cetyltrimethylamonium bromide (CTABr) micelles were examined using 1H NMR spectroscopy. Seven of the nine pr...

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Veröffentlicht in:Langmuir 2016-08, Vol.32 (31), p.7814-7820
Hauptverfasser: Sarker, Ashish K., Cashin, Patrick J., Balakrishnan, Vimal K., Exall, Kirsten, Buncel, Erwin, Brown, R. Stephen
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Interface Components: Nanops, Colloids, Emulsions, Surfactants, Proteins, Polymers
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container_end_page 7820
container_issue 31
container_start_page 7814
container_title Langmuir
container_volume 32
creator Sarker, Ashish K.
Cashin, Patrick J.
Balakrishnan, Vimal K.
Exall, Kirsten
Buncel, Erwin
Brown, R. Stephen
description Interactions of nine sulfonamide antibiotics (sulfadoxine, sulfathiazole, sulfamethoxazole, sulfamerazine, sulfadiazine, sulfamethazine, sulfacetamide, sulfaguanidine, and sulfanilamide) with cetyltrimethylamonium bromide (CTABr) micelles were examined using 1H NMR spectroscopy. Seven of the nine provided a significant change in the 1H NMR chemical shift such that the magnitude and direction (upfield vs downfield) of the chemical shift could be used to propose a locus and orientation of the sulfonamide within the micelle structure. The magnitude of the chemical shift was used to estimate the binding constant for seven sulfonamides with CTABr micelles, providing values and an overall pattern consistent with previous studies of these sulfonamides.
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title Binding of Sulfonamide Antibiotics to CTABr Micelles Characterized Using 1H NMR Spectroscopy
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