Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui

Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui

LCMS analysis of an extract of the New Zealand tunicate Synoicum kuranui showed evidence for numerous new rubrolides. Following a mass spectrometry-guided isolation procedure, new hydrated rubrolides V and W (5 and 6), along with previously reported rubrolide G (3), were isolated and characterized u...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2021-02, Vol.84 (2), p.544-547
Hauptverfasser: Bracegirdle, Joe, Stevenson, Luke J, Sharrock, Abigail V, Page, Michael J, Vorster, Jan A, Owen, Jeremy G, Ackerley, David F, Keyzers, Robert A
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container_end_page 547
container_issue 2
container_start_page 544
container_title Journal of natural products (Washington, D.C.)
container_volume 84
creator Bracegirdle, Joe
Stevenson, Luke J
Sharrock, Abigail V
Page, Michael J
Vorster, Jan A
Owen, Jeremy G
Ackerley, David F
Keyzers, Robert A
description LCMS analysis of an extract of the New Zealand tunicate Synoicum kuranui showed evidence for numerous new rubrolides. Following a mass spectrometry-guided isolation procedure, new hydrated rubrolides V and W (5 and 6), along with previously reported rubrolide G (3), were isolated and characterized using MS and NMR. The anti-bacterial and cell cytotoxic activity of the compounds were compared to the potent anti-MRSA compound rubrolide A; hydration across the C-5/C-6 bond was shown to abrogate antibacterial activity.
doi_str_mv 10.1021/acs.jnatprod.0c01248
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title Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui
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