Identification of N‑Phenyl‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis

A series of N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives with NF-κB inducing kinase (NIK) inhibitory activity were obtained through structure-based drug design and synthetic chemistry. Among them, 4-(3-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-morpholinophenyl)-2-(thiazol-2-yl)but-...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-07, Vol.63 (13), p.6748-6773
Hauptverfasser:	Zhu, Yuqin, Ma, Yuxiang, Zu, Weidong, Song, Jianing, Wang, Hua, Zhong, You, Li, Hongmei, Zhang, Yanmin, Gao, Qianqian, Kong, Bo, Xu, Junyu, Jiang, Fei, Wang, Xinren, Li, Shuwen, Liu, Chenhe, Liu, Haichun, Lu, Tao, Chen, Yadong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Identification of N‑Phenyl‑7H‑pyrrolo[2,3‑d]­pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis

Identification of N‑Phenyl‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis