Chemical and Biological Reduction of the Radical SAM Enzyme CPH4 Synthase

The radical S-adenosyl-l-methionine (SAM) superfamily is a large and growing group of enzymes that conduct complex radical-mediated transformations. A one-electron reduction of SAM via the +1 state of the cubane [4Fe-4S] cluster generates a 5′-deoxyadenosyl radical, which initiates turnover. The [4F...

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Veröffentlicht in:	Biochemistry (Easton) 2015-05
Hauptverfasser:	Bruender, Nathan A, Young, Anthony P, Bandarian, Vahe
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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