High efficacy of sofosbuvir/velpatasvir and impact of baseline resistance‐associated substitutions in hepatitis C genotype 3 infection von von Felden, J., Vermehren, J., Ingiliz, P., Mauss, S., Lutz, T., Simon, K. G., Busch, H. W., Baumgarten, A., Schewe, K., Hueppe, D., Boesecke, C., Rockstroh, J. K., Daeumer, M., Luebke, N., Timm, J., Schulze zur Wiesch, J., Sarrazin, C., Christensen, S.

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Editorial: genotype 3 HCV—who still needs ribavirin in a pan‐genotypic era? Authors’ reply von Felden, J., Vermehren, J., Schulze zur Wiesch, J., Sarrazin, C., Christensen, S.

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Successful treatment of chronic hepatitis C with ground ledipasvir/sofosbuvir in a patient with Crohn's disease and short bowel syndrome von Felden, J., Scheurich, C., Yamamura, J., Brainard, D. M., Mogalian, E., Lohse, A. W., Schulze zur Wiesch, J.

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EpCAM-positive circulating tumor cells as liquid biomarker for early micrometastases and HCC recurrence risk von Schulze, K, von Felden, J, Krech, T, Ewald, F, Nashan, B, Lohse, A.W, Riethdorf, S, Wege, H

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Rheumatological Patients are at Risk of Chronic HEV Infection: A Multicentric European Study von Pischke, S, Von Felden, J, Peron, J.M, Alric, L, Wedemeyer, H, Spengler, U, Schnitzler, P, Bettinger, D, Schlabe, S, Cornelissen, J, zu Siederdissen, C.H, Giordani, M.T, Par, G, Thimme, R, Lohse, A.W, Aitken, C, de Man, R.A, Mallet, V

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Hepatitis E in Haematological Patients in Europe: A Multicentre Study von Von Felden, J, Alric, L, Schnitzler, P, Bettinger, D, Peron, J.M, Wedemeyer, H, Spengler, U, Schlabe, S, Hoener zu Siederdissen, C, Cornelissen, J, Giordani, M.T, Par, G, Aitken, C, Thimme, R, Lohse, A.W, de Man, R.A, Pischke, S, Mallet, V

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Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study von Buch, Stephan, Innes, Hamish, Lutz, Philipp Ludwig, Nischalke, Hans Dieter, Marquardt, Jens U, Fischer, Janett, Weiss, Karl Heinz, Rosendahl, Jonas, Marot, Astrid, Krawczyk, Marcin, Casper, Markus, Lammert, Frank, Eyer, Florian, Vogel, Arndt, Marhenke, Silke, von Felden, Johann, Sharma, Rohini, Atkinson, Stephen Rahul, McQuillin, Andrew, Nattermann, Jacob, Schafmayer, Clemens, Franke, Andre, Strassburg, Christian, Rietschel, Marcella, Altmann, Heidi, Sulk, Stefan, Thangapandi, Veera Raghavan, Brosch, Mario, Lackner, Carolin, Stauber, Rudolf E, Canbay, Ali, Link, Alexander, Reiberger, Thomas, Mandorfer, Mattias, Semmler, Georg, Scheiner, Bernhard, Datz, Christian, Romeo, Stefano, Ginanni Corradini, Stefano, Irving, William Lucien, Morling, Joanne R, Guha, Indra Neil, Barnes, Eleanor, Ansari, M Azim, Quistrebert, Jocelyn, Valenti, Luca, Müller, Sascha A, Morgan, Marsha Yvonne, Dufour, Jean-François, Trebicka, Jonel, Berg, Thomas, Deltenre, Pierre, Mueller, Sebastian, Hampe, Jochen, Stickel, Felix

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Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals von Dietz, Julia, Peiffer, Kai-Henrik, Hinrichsen, Holger, Buggisch, Peter, Felten, Gisela, Hüppe, Dietrich, Lutz, Thomas, Schott, Eckart, Berg, Christoph, Spengler, Ulrich, von Hahn, Thomas, Berg, Thomas, Vogelmann, R., Giostra, E., Berg, C., Wedemeyer, H., De Gottardi, A., Discher, T., Roeb, E., Wietzke-Braun, P., Herrmann, A., Kodal, A., Löbermann, M., Schulze zur Wiesch, J., Thimme, R., Schattenberg, J., Sprinzl, M., Schmidt, J., Schott, E., Siebler, J., Stauber, R., Schmiegel, W., Stremmel, W., Strey, B., Trautwein, C., Zachoval, R., Angeli, W., Gattringer, H., Genné, D., Hirschi, C., Kanzler, S., Kullig, U., Magenta, L., Menges, M., Niederau, C., Riecken, B., Roth, J., Schöfl, R., Schneider, A., Seelhoff, A., Semela, D., Walter, E., Winzer, T., Abels, W., Audebert, F., Barthel, K., Benninger, J., Bohr, U., Naumann, U., Bruch, H.R., Chirca, C., Dienethal, A., Dietel, P., Dreher, F., Emke, F., Fischer, J., Frederking, D., Frick, B., Goebel, F., Göbel, U., Herder, M., Heuer, S., Höffl, K.H., Hofmann, W.P., John, C., Kallinowski, B., Khaykin, P., Köster, A., Künzig, B., Littman, M., Löhr, H., Lutz, U., Maurer, P., Moritzen, D., Mroß, M., Mundlos, M., Ningel, K., Oelmann, A., Pascher, E., Philipp, A., Rietzler, S., Schmidt, W., Schwenzer, J., Simon, K., Steffens, H., Tacke, W., Thieringer, J., Ullrich, J., Werheid-Dobers, M., Zipf, A.

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157P Soluble and EV-bound CD27 act as antagonistic biomarkers in patients with solid tumors undergoing immunotherapy von Gorgulho, J., Loosen, S.H., Masood, R., Buescher, G., Kochheise, L., Schmidt, C., Schulze, K., Sinn, M., Fritzsche, B., Altfeld, M., Peine, S., Wikman, H., Huber, S., Lohse, A.W., Beier, F., Brümmendorf, T.H., Bokemeyer, C., Lüdde, T., Von Felden, J.

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T.07.3: CHARACTERISTICS AND OUTCOMES OF IMMUNOTHERAPYRELATED LIVER INJURY IN PATIENTS WITH HEPATOCELLULAR CARCINOMA COMPARED TO PATIENTS WITH ADVANCED SOLID TUMOURS von Celsa, C., Cabibbo, G., Fulgenzi, C.A.M., Scheiner, B., D'Alessio, A., Manfredi, G.F., Stefanini, B., Marron, T., Saeed, A., Pinter, M., Huang, Y., Pillai, A., Schönlein, M., Von Felden, J., Galle, P.R., Kudo, M., Rimassa, L., Singal, A.G., Chon, H.J., Hsu, W., Vogel, A., Brunetti, L., Pinto, C., Bersanelli, M., Cortellini, A., Cammà, C., Pinato, D.J.

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Long-term persistence of HCV resistance-associated substitutions after DAA treatment failure von Dietz, Julia, Müllhaupt, Beat, Buggisch, Peter, Graf, Christiana, Mauss, Stefan, Schulze zur Wiesch, Julian, Klinker, Hartwig, Müller, Tobias, Berg, Thomas, Neumann-Haefelin, Christoph, Sarrazin, Christoph, Canbay, A., Steckstor, W., Schmiegel, W., De Gottardi, A., Herrmann, A., Klinker, H., Schulze, P., Kodal, A., Götze, T., Jordan, S., Muche, M., Reinhardt, L., Ellenrieder, V., Galle, P., Boettler, T., Teufel, A., Ebert, M., Wietzke-Braun, P., Günther, R., Zizer, E., Seufferlein, T., Beckebaum, S., Durmashkina, E., Hackelsberger, A., Schöfl, R., Hartmann, C., Kanzler, S., Terziroli Beretta-Piccoli, B., Rambach, W., Reiser, M., Scholz, D., Seelhoff, A., Weber, A., Adler, M., Barth, R., Becker, W., Berzow, D., Blaukat, O., Busch, N., Chirca, C., Diehl, M., Dikopoulos, N., Ehrle, U., Hüppe, D., Frederking, D., Geyer, P., Schwind, H.R., Graf, R., Heuchel, T., Höffl, K.-H., Holst, F., Hurst, A., Kallinowski, B., Kerzel, W., Khaykin, P., Wolfratshausen, Kochsiek, T., Körfer, A., Künzig, B., Link, R., Löhr, H., Lutz, T., Mahle, I., Mroß, M., Oelmann, A., Olejnik, H., Pascher, E., Petersen, J., Polzien, F., Rietzler, S., Rössle, M., Rump, A., Schewe, C., Hoffmann, C., Schmidtler-von Fabris, J., Schneider, L., Niehaus-Hahn, S., Schwenzer, J., Seegers, B., Seidel, T., Simon, K., Stenschke, F., Stein, K., Sternfeld, T., Teuber, G., Ullrich, J., Weinberger, F., Werheid-Dobers, M., Winter, T.

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Serum immune signatures predict HCC development in DAA-treated HCV patients von Debes, J., van Tilborg, M., Grooshuismink, A., Hansen, B., Wiesch, J.S.Z., von Felden, J., de Knegt, R., Boonstra, A.

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FRI-367 - Serum immune signatures predict HCC development in DAA-treated HCV patients von Debes, J., van Tilborg, M., Grooshuismink, A., Hansen, B., Wiesch, J.S.Z., von Felden, J., de Knegt, R., Boonstra, A.

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Identification of factors associated with primary refractoriness to atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma von Manfredi, G.F., Fulgenzi, C.A.M., D'Alessio, A., Celsa, C., Stefanini, B., Cheon, J., Ang, C., Marron, T.U., Saeed, A., Wietharn, B., Pressiani, T., Pinter, M., Scheiner, B., Huang, Yi-Hsiang, Phen, S., Naqash, A. Rafeh, Piscaglia, F., Lin, R. Po-Ting, -yen Lin, C., Dalbeni, A., Vivaldi, C., Masi, G., Thimme, R., Vogel, A., Schönlein, M., von Felden, J., Schulze, K., Wege, H., Galle, P.R., Kudo, M., Rimassa, L., Singal, A., Sharma, R., Cortellini, A., Jae Chon, H., Burlone, M., Pirisi, M., Pinato, D.J.

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Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury von Kapopara, Piyushkumar R., Felden, Johann von, Soehnlein, Oliver, Wang, Yong, Napp, L. Christian, Sonnenschein, Kristina, Wollert, Kai C., Schieffer, Bernhard, Gaestel, Matthias, Bauersachs, Johann, Bavendiek, Udo

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Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study von Buch, S, Innes, H, Lutz, PL, Nischalke, HD, Marquardt, JU, Fischer, J, Weiss, KH, Rosendahl, J, Marot, A, Krawczyk, M, Casper, M, Lammert, F, Eyer, F, Vogel, A, Marhenke, S, Von Felden, J, Sharma, R, Atkinson, SR, McQuillin, A, Nattermann, J, Schafmayer, C, Franke, A, Strassburg, C, Rietschel, M, Altmann, H, Sulk, S, Thangapandi, VR, Brosch, M, Lackner, C, Stauber, RE, Canbay, A, Link, A, Reiberger, T, Mandorfer, M, Semmler, G, Scheiner, B, Datz, C, Romeo, S, Ginanni Corradini, S, Irving, WL, Morling, JR, Guha, IN, Barnes, E, Ansari, MA, Quistrebert, J, Valenti, L, Müller, SA, Morgan, MY, Dufour, J-F, Trebicka, J, Berg, T, Deltenre, P, Mueller, S, Hampe, J, Stickel, F

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Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections von Schulze zur Wiesch, Julian, Mauss, Stefan, Seegers, Barbara, Antoni, Christoph, Berger, Annemarie, Buggisch, Peter, Backhus, Johanna, Boettler, Tobias, Stauber, Rudolf, Giostra, E., Berning, M., Discher, T., Trauth, J., Günther, R., Herrmann, A., Schulze, P., Kocheise, F., Müller-Schilling, M., Kremer, A., Ganslmayer, M., Götze, T., Lohse, A., von Felden, J., Müller, T., Brockmeyer, N.H., Thimme, R., Vogelmann, R., Tomasiewicz, K., Tacke, F., Weber, T., Mayerle, J., Doberauer, C., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Heyer, T., Hirschi, C., Kraus, M., Kullig, U., Wollschläger, S., Beretta-Piccoli, B. Terziroli, Muehlenberg, K., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Riecken, B., Rieke, A., Schneider, A., Schott, E., Stich, A., Stickel, F., Abels, W., Bästlein, E., Barth, R., Benninger, J., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Burkhard, O., Delker, R., Dienethal, A., Dietel, P., Emke, F., Frick, B., Friese, G., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Härter, G., Hunstiger, M., Kerzel, W., Klarhof, M., Kochsiek, T., Kuhn, M., Littman, M., Lutz, T., Lutz, U., Mahle, I., Mroß, M., Naumann, U., Oelmann, A., Petersen, J., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Schmidt-Heinevetter, G., Seitel, G., Steinmüller, M., Svensson, K., Teubner, K., Tomesch, A., Usadel, S., Zehnter, E.

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Impact of older age in patients receiving atezolizumab and bevacizumab for hepatocellular carcinoma von Vithayathil, M, D'Alessio, A, Fulgenzi, CAM, Nishida, N, Schoenlein, M, Von Felden, J, Schulze, K, Wege, H, Saeed, A, Wietharn, B, Hildebrand, H, Wu, L, Ang, C, Marron, TU, Weinmann, A, Galle, PR, Bettinger, D, Bengsch, B, Vogel, A, Balcar, L, Scheiner, B, Lee, P-C, Huang, Y-H, Amara, S, Muzaffar, M, Naqash, AR, Cammarota, A, Personeni, N, Pressiani, T, Pinter, M, Cortellini, A, Kudo, M, Rimassa, L, Pinato, DJ, Sharma, R

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FRI-100 - EpCAM-positive circulating tumor cells as liquid biomarker for early micrometastases and HCC recurrence risk von Schulze, K., von Felden, J., Krech, T., Ewald, F., Nashan, B., Lohse, A.W., Riethdorf, S., Wege, H.

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Characteristics and outcomes of immunotherapy-related liver injury in patients with hepatocellular carcinoma compared to patients with advanced solid tumours von Celsa, C., Cabibbo, G., Fulgenzi, C. AM, Scheiner, B., d'Alessio, A., Manfredi, G. F, Nishida, N., Ang, C., Marron, T.U., Saeed, A., Wietharn, B., Pinter, M., Cheon, J., Huang, Yi-Hsiang, Lee, Pei-Chang, Phen, S., Gampa, A., Pillai, A., Vivaldi, C., Salani, F., Masi, G., Roehlen, N., Thimme, R., Vogel, A., Schönlein, M., von Felden, J., Schulze, K., Wege, H., Galle, P.R., Kudo, M., Rimassa, L., Singal, A.G., Tomb, P. El, Ulahannan, S., Parisi, A., Chon, H. Jae, Hsu, Wei-Fan, Stefanini, B., Verzoni, E., Giusti, R., Veccia, A., Catino, A., Aprile, G., Guglielmini, P.F., Di Napoli, M., Ermacora, P., Antonuzzo, L., Rossi, E., Verderame, F., Zustovich, F., Ficorella, C., Di Pietro, F.R., Battelli, N., Negrini, G., Grossi, F., Bordonaro, R., Pipitone, S., Banzi, M., Ricciardi, S., Laera, L., Russo, A., De Giorgi, U., Cavanna, L., Sorarù, M., Montesarchio, V., Bordi, P., Brunetti, L., Pinto, C., Bersanelli, M., Cortellini, A., Cammà, C., Pinato, D.J.

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