Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist von Willard, Francis S., Douros, Jonathan D., Gabe, Maria, Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J. C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D'Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.

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Structural basis of odorant recognition by a human odorant receptor von Billesbølle, Christian B., de March, Claire A., van der Velden, Wijnand J. C., Ma, Ning, Tewari, Jeevan, del Torrent, Claudia Llinas, Li, Linus, Faust, Bryan, Vaidehi, Nagarajan, Matsunami, Hiroaki, Manglik, Aashish

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Unraveling allostery within the angiotensin II type 1 receptor for Gα q and β-arrestin coupling von Cao, Yubo, van der Velden, Wijnand J C, Namkung, Yoon, Nivedha, Anita K, Cho, Aaron, Sedki, Dana, Holleran, Brian, Lee, Nicholas, Leduc, Richard, Muk, Sanychen, Le, Keith, Bhattacharya, Supriyo, Vaidehi, Nagarajan, Laporte, Stéphane A

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A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor von Sun, Wen, Chen, Li-Nan, Zhou, Qingtong, Zhao, Li-Hua, Yang, Dehua, Zhang, Huibing, Cong, Zhaotong, Shen, Dan-Dan, Zhao, Fenghui, Zhou, Fulai, Cai, Xiaoqing, Chen, Yan, Zhou, Yan, Gadgaard, Sarina, van der Velden, Wijnand J. C., Zhao, Suwen, Jiang, Yi, Rosenkilde, Mette M., Xu, H. Eric, Zhang, Yan, Wang, Ming-Wei

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Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology von Gadgaard, Sarina, Velden, Wijnand J. C., Schiellerup, Sine P., Hunt, Jenna Elizabeth, Gabe, Maria B. N., Windeløv, Johanne Agerlin, Boer, Geke Aline, Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens J., Hartmann, Bolette, Rosenkilde, Mette M.

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Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP sys... von Gabe, Maria Buur Nordskov, van der Velden, Wijnand J. C., Gadgaard, Sarina, Smit, Florent Xavier, Hartmann, Bolette, Bräuner‐Osborne, Hans, Rosenkilde, Mette Marie

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Molecular interactions of full-length and truncated GIP peptides with the GIP receptor – A comprehensive review von Gabe, Maria Buur Nordskov, van der Velden, Wijnand J.C., Smit, Florent Xavier, Gasbjerg, Lærke Smidt, Rosenkilde, Mette Marie

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Bayesian network models identify cooperative GPCR:G protein interactions that contribute to G protein coupling von Mukhaleva, Elizaveta, Ma, Ning, van der Velden, Wijnand J.C., Gogoshin, Grigoriy, Branciamore, Sergio, Bhattacharya, Supriyo, Rodin, Andrei S., Vaidehi, Nagarajan

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Identification of a conserved chemokine receptor motif that enables ligand discrimination von Larsen, Olav, van der Velden, Wijnand J C, Mavri, Maša, Schuermans, Sara, Rummel, Pia C, Karlshøj, Stefanie, Gustavsson, Martin, Proost, Paul, Våbenø, Jon, Rosenkilde, Mette M

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Molecular and in vivo phenotyping of missense variants of the human glucagon receptor von van der Velden, Wijnand J.C., Lindquist, Peter, Madsen, Jakob S., Stassen, Roderick H.M.J., Wewer Albrechtsen, Nicolai J., Holst, Jens J., Hauser, Alexander S., Rosenkilde, Mette M.

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Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2 von Ortiz Zacarías, Natalia V, van Veldhoven, Jacobus P. D, Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C, Zweemer, Annelien J. M, Kreekel, Roy M, Oenema, Kenny, Lenselink, Eelke B, Heitman, Laura H, IJzerman, Adriaan P

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Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor von Smit, Florent X., van der Velden, Wijnand J.C., Kizilkaya, Hüsün S., Nørskov, Amalie, Lückmann, Michael, Hansen, Tobias N., Sparre-Ulrich, Alexander H., Qvotrup, Katrine, Frimurer, Thomas M., Rosenkilde, Mette M.

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Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor von Yuliantie, Elita, van der Velden, Wijnand J.C., Labroska, Viktorija, Dai, Antao, Zhao, Fenghui, Darbalaei, Sanaz, Deganutti, Giuseppe, Xu, Tongyang, Zhou, Qingtong, Yang, Dehua, Rosenkilde, Mette M., Sexton, Patrick M., Wang, Ming-Wei, Wootten, Denise

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Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors von van der Velden, Wijnand J. C, Heitman, Laura H, Rosenkilde, Mette M

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Identification of a conserved chemokine receptor motif that enables ligand discrimination von Larsen, Olav, van der Velden, Wijnand J.C, Mavri, Masa, Schuermans, Sara, Rummel, Pia C, Karlshoj, Stefanie, Gustavsson, Martin, Proost, Paul, Vabeno, Jon, Rosenkilde, Mette M

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GLP‑1 Val8: A Biased GLP‑1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats von van der Velden, Wijnand J. C, Smit, Florent X, Christiansen, Charlotte B, Møller, Thor C, Hjortø, Gertrud M, Larsen, Olav, Schiellerup, Sine P, Bräuner-Osborne, Hans, Holst, Jens J, Hartmann, Bolette, Frimurer, Thomas M, Rosenkilde, Mette M

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Selective Allosteric Modulation of N‑Terminally Cleaved, but Not Full Length CCL3 in CCR1 von Larsen, Olav, Lückmann, Michael, van der Velden, Wijnand J. C, Oliva-Santiago, Marta, Brvar, Matjaz, Ulven, Trond, Frimurer, Thomas M, Karlshøj, Stefanie, Rosenkilde, Mette M

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