Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma von Dickson, M.A., Mahoney, M.R., Tap, W.D., D'Angelo, S.P., Keohan, M.L., Van Tine, B.A., Agulnik, M., Horvath, L.E., Nair, J.S., Schwartz, G.K.

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Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: A randomized controlled open-label trial von Adenis, A., Blay, J.-Y., Bui-Nguyen, B., Bouché, O., Bertucci, F., Isambert, N., Bompas, E., Chaigneau, L., Domont, J., Ray-Coquard, I., Blésius, A., Van Tine, B.A., Bulusu, V.R., Dubreuil, P., Mansfield, C.D., Acin, Y., Moussy, A., Hermine, O., Le Cesne, A.

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An analysis of efficacy and safety of olaratumab + doxorubicin or doxorubicin alone in patients with uterine leiomyosarcoma: A retrospective assessment of the phase 1b/2 study JGDG von Van Tine, B.A, Peterson, P.M, Shahir, A, Ilaria, R, Jones, R.L

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Improved clinical trial enrollments for uterine leiomyosarcoma patients after gynecologic oncology partnership with a sarcoma center von Lange, S.E.S, Liu, J, Adkins, D.R, Powell, M.A, Van Tine, B.A, Mutch, D.G

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1321 Efficacy and safety of trabectedin (T) or dacarbazine (D) in an elderly patient subgroup (65 years) with advanced leiomyosarcoma (LMS) or liposarcoma (LPS) after prior chemoth... von Von Mehren, M, Demetri, G.D, Schuetze, S.M, Jones, R.L, Milhem, M, Elias, A, Van Tine, B.A, Hamm, J, Khokhar, N.Z, McCarthy, S, Park, Y.C, Knoblauch, R.E, Parekh, T.V, Maki, R.G, Patel, S.R

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Gyn/onc partnership with sarcoma center yields superior clinical trial enrollments for uterine leiomyosarcoma patients von Lange, S.S, Liu, J, Hagemann, A.R, Massad, L.S, Adkins, D.A, Thaker, P.H, Fuh, K.C, Powell, M.A, Van Tine, B.A, Mutch, D.G

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Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors von Gounder, Mrinal, Ratan, Ravin, Alcindor, Thierry, Schöffski, Patrick, van der Graaf, Winette T., Wilky, Breelyn A., Riedel, Richard F., Lim, Allison, Smith, L. Mary, Moody, Stephanie, Attia, Steven, Chawla, Sant, D’Amato, Gina, Federman, Noah, Merriam, Priscilla, Van Tine, Brian A., Vincenzi, Bruno, Benson, Charlotte, Bui, Nam Quoc, Chugh, Rashmi, Tinoco, Gabriel, Charlson, John, Dileo, Palma, Hartner, Lee, Lapeire, Lore, Mazzeo, Filomena, Palmerini, Emanuela, Reichardt, Peter, Stacchiotti, Silvia, Bailey, Howard H., Burgess, Melissa A., Cote, Gregory M., Davis, Lara E., Deshpande, Hari, Gelderblom, Hans, Grignani, Giovanni, Loggers, Elizabeth, Philip, Tony, Pressey, Joseph G., Kummar, Shivaani, Kasper, Bernd

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1721MO Safety and efficacy of olutasidenib, an IDH1 mutant inhibitor, for the treatment of recurrent/relapsed or locally advanced or metastatic IDH1 mutated chondrosarcoma von Jones, R.L., Groisberg, R., Blay, J-Y., Colman, H., de la Fuente, M., Milhem, M., Roxburgh, P., Chao, M.M., Tian, H., Duffaud, F., Massard, C.P., Van Tine, B.A.

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1766P Updated results of the RINGSIDE phase II trial and open-label extension of AL102 for treatment of desmoid tumors von Kasper, B., Gounder, M., Chugh, R., Singh, A., Van Tine, B.A., Andelkovic, V., Choy, E., Lewin, J., Ratan, R., Yovell, J., Jones, R.L.

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1757P Proceedings of the think tank for osteosarcoma medical advisory board meeting von Chawla, S.P., Van Tine, B.A., Federman, N., Schwab, J., Jones, R.L., Subbiah, V., Swaney, W., Chawla, N.S., Spencer, T., Afshar, N., Hoos, W., Feldman, N., Gordon, E.M.

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1934P Pharmacokinetics of unesbulin in a phase Ib study of patients with advanced leiomyosarcoma von Van Tine, B.A., Ingham, M.A., Attia, S., Meyer, C.F., Baird, J.D., D'Silva, D., O'Keefe, K., Kong, R., Maliakal, P., Gao, L., Schwartz, G.K.

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1929P phase II results from the RINGSIDE phase II/III trial of AL102 for treatment of desmoid tumors von Kasper, B., Gounder, M., Chugh, R., Agulnik, M., Van Tine, B.A., Andelkovic, V., Choy, E., Lewin, J., Ratan, R., Gordon, G., Yovell, J., Gutierrez, A., Jones, R.L.

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2 Oral: Preliminary results from SEACRAFT-1: An open-label study of naporafenib with trametinib in patients with locally advanced unresectable or metastatic solid tumor malignancie... von Fontana, E., Spira, A.I., McKean, M., Lee, J., Chau, N., Winquist, E., Kim, I., Hong, S.H., Van Tine, B.A., Fawole, A., Shoemaker, R., Cui, Y., Sutton, R., Antal, J.M., Morris, S.R., Hong, D.S.

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LBA2 DeFi: A phase III, randomized controlled trial of nirogacestat versus placebo for progressing desmoid tumors (DT) von Kasper, B., Ratan, R., Alcindor, T., Schoeffski, P., van der Graaf, W.T.A., Wilky, B.A., Riedel, R.F., Lim, A., Smith, L.M., Moody, S., Attia, S., Chawla, S.P., D'Amato, G., Federman, N., Van Tine, P., Van Tine, B.A., Vincenzi, B., Kummar, S., Gounder, M.M.

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97P Bcl-xL prevents the arginine starvation induced by PEGylated arginine deiminase (ADI-PEG20) from inducing apoptosis von Van Tine, B.A., Panda, P., Rogers, L., Oyama, T.

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Efficacy and tolerability of trabectedin in elderly patients with sarcoma: subgroup analysis from a phase III, randomized controlled study of trabectedin or dacarbazine in patients... von Jones, R.L., Demetri, G.D., Schuetze, S.M., Milhem, M., Elias, A., Van Tine, B.A., Hamm, J., McCarthy, S., Wang, G., Parekh, T., Knoblauch, R., Hensley, M.L., Maki, R.G., Patel, S., von Mehren, M.

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612O Preliminary results from a phase I study of CFT1946, a novel BIDAC degrader in mutant BRAF V600 solid tumors von Vieito, M., Mckean, M., Spira, A.I., Rosen, E., Rodon, J., Moreno Garcia, V., Gambardella, V., Saavedra, O., Cousin, S., Cassier, P., Korakis, I., Van Tine, B.A., Ma, V.T-L., Ali, A., Hinojosa, E., Lobbardi, R., Liu, H., Hurh, E., Reyno, L., Buchbinder, E.

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Angiosarcoma: History of Prior Radiation Therapy is an Adverse Prognostic Factor von Gabani, P., Merfeld, E., Chrisinger, J., Van Tine, B.A., Zoberi, I., Kim, H., Michalski, J.M.

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160TiP A phase I/II study of CFT1946, a novel BIDAC degrader targeting mutant BRAF V600 solid tumors including metastatic colorectal cancer (CRC) in combination with cetuximab von Villar, M. Vieito, McKean, M., Spira, A., Rosen, E., Rodon, J., Moreno, V., Gambardella, V., Santa Gadea, O. Saavedra, Cousin, S., Cassier, P., Korakis, I., Van Tine, B.A., Wang, J.S., Ma, V.T-L., Fernandez, M.E. Elez, Pelster, M., Hinojosa, E., Lobbardi, R., Hurh, E., Buchbinder, E.

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1488MO Initial results of phase II/III trial of AL102 for treatment of desmoid tumors (DT) von Gounder, M.M., Jones, R.L., Chugh, R., Agulnik, M., Singh, A., Van Tine, B.A., Andelkovic, V., Choy, E., Lewin, J., Ratan, R., Kaplan, J.B., Yovell, J., Gordon, G., Kasper, B.

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