High Incidence of Protein-Truncating TP53 Mutations in BRCA1-Related Breast Cancer von HOLSTEGE, Henne, JOOSSE, Simon A, VAN OOSTROM, Conny Th. M, NEDERLOF, Petra M, DE VRIES, Annemieke, JONKERS, Jos

Volltext

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA von Vries, Annemieke de, van Oostrom, Conny Th. M, Hofhuis, Frans M. A, Dortant, Paul M, Berg, Rob J. W, Gruijl, Frank R. de, Wester, Piet W, van Kreijl, Coen F, Capel, Peter J. A, Steeg, Harry van, Verbeek, Sjef J

Volltext

Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells von Verhofstad, Nicole, van Oostrom, Conny Th M, Zwart, Edwin, Maas, Lou M, van Benthem, Jan, van Schooten, Frederik J, van Steeg, Harry, Godschalk, Roger W L

Volltext

Targeted Point Mutations of p53 Lead to Dominant-Negative Inhibition of Wild-Type p53 Function von de Vries, Annemieke, Flores, Elsa R., Miranda, Barbara, Hsieh, Harn-Mei, Conny Th. M. van Oostrom, Sage, Julien, Jacks, Tyler

Volltext

DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene von Verhofstad, Nicole, van Oostrom, Conny Th.M, van Benthem, Jan, van Schooten, Frederik J, van Steeg, Harry, Godschalk, Roger W.L

Volltext

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23 von MacPherson, David, Kim, Jungho, Kim, Teresa, Rhee, Byung Kirl, van Oostrom, Conny ThM, DiTullio Jr, Richard A, Venere, Monica, Halazonetis, Thanos D, Bronson, Roderick, de Vries, Annemieke, Fleming, Mark, Jacks, Tyler

Volltext

p53 Heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice von HOOGERVORST, Esther M, VAN OOSTROM, Conny Th. M, BEEMS, Rudolf B, VAN BENTHEM, Jan, GIELIS, Siska, VERMEULEN, Jolanda P, WESTER, Piet W, VOS, Joseph G, DE VRIES, Annemieke, VAN STEEG, Harry

Volltext

2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair von Hoogervorst, Esther M., Oostrom, Conny Th. M. van, Beems, Rudolf B., Benthem, Jan van, Berg, Jolanda van den, Kreijl, Coen F. van, Vos, Joseph G., Vries, Annemieke de, van Steeg, Harry

Volltext

Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice von Hoogervorst, Esther M., de Vries, Annemieke, Beems, Rudolf B., van Oostrom, Conny Th.M., Wester, Piet W., Vos, Joseph G., Bruins, Wendy, Roodbergen, Marianne, Cassee, Flemming R., Vijg, Jan, van Schooten, Frederik-Jan, van Steeg, Harry

Volltext

Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice von Verhofstad, Nicole, Pennings, Jeroen L A, van Oostrom, Conny Th M, van Benthem, Jan, van Schooten, Frederik J, van Steeg, Harry, Godschalk, Roger W L

Volltext

Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas von Hoogervorst, Esther M, Bruins, Wendy, Zwart, Edwin, van Oostrom, Conny Th M, van den Aardweg, Gerard J, Beems, Rudolf B, van den Berg, Jolanda, Jacks, Tyler, van Steeg, Harry, de Vries, Annemieke

Volltext

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation von Tutt, Andrew N J, van Oostrom, Conny Th M, Ross, Gillian M, van Steeg, Harry, Ashworth, Alan

Volltext

DNA Repair—Deficient Xpa and Xpa/p53+/- Knock-Out Mice: Nature of the Models von Van Steeg, Harry, De Vries, Annemieke, Van Oostrom, Conny TH. M., Van Benthem, Jan, Beems, Rudolf B., Van Kreijl, Coen F.

Volltext

Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice von van Oostrom, Conny Th. M., Boeve, Miranda, van den Berg, Jolanda, de Vries, Annemieke, Dollé, Martijn E.T., Beems, Rudolf B., van Kreijl, Coen F., Vijg, Jan, van Steeg, Harry

Volltext

Nucleotide sequence of the human ornithine decarboxylase gene von VAN STEEG, H, VAN OOSTROM, C. T. M, MARTENS, J. W. M, VAN KREY, C. F, SCHEPENS, J, WIERINGA, B

Volltext

Lack of p53 ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-lnduced bladder tumors but not ionizing radiation-induced lymphomas von HOOGERVORST, Esther M, BRUINS, Wendy, ZWART, Edwin, VAN OOSTROM, Conny Th. M, VAN DEN AARDWEG, Gerard J, BEEMS, Rudolf B, VAN DEN BERG, Jolanda, JACKS, Tyler, VAN STEEG, Harry, DE VRIES, Annemieke

Volltext

Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N-n-butyl-N-nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo von Bol, Sandra A.M., van Steeg, Harry, van Oostrom, Conny Th.M., Tates, Ad D., Vrieling, Harry, de Groot, Anton J.L., Mullenders, Leon H.F., van Zeeland, Albert A., Jansen, Jacob G.

Volltext

Use of Eμ-PIM-1 transgenic mice for short-term in vivo carcinogenicity testing : Lymphoma induction by benzo[a]pyrene, but not by TPA von KROESE, E. D, DORTANT, P. M, VAN STEEG, H, VAN OOSTROM, C. T. M, VAN DER HOUVEN VAN OORDT, C. W, VAN KRANEN, H. J, DE VRIES, A, WESTER, P. W, VAN KREIJL, C. F

Volltext

Cloning and characterization of the mouse XPAC gene von van Oostrom, Conny Th.M., Vries, Annemieke de, Verbeek, Sjef J., van Kreijil, Coen F., Steeg, Harry van

Volltext

Effect of heterozygous loss ofp53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficientXPA mice von van Oostrom, Conny Th. M., Boeve, Miranda, van den Berg, Jolanda, de Vries, Annemieke, Doll, Martijn E.T., Beems, Rudolf B., van Kreijl, Coen F., Vijg, Jan, van Steeg, Harry

Volltext