Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling von Ponsioen, Bas, Post, Jasmin B., Buissant des Amorie, Julian R., Laskaris, Dimitrios, van Ineveld, Ravian L., Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F., Vries, Rob G. J., Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B., Trusolino, Livio, Bos, Johannes L., Snippert, Hugo J. G.

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Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids von van Ineveld, Ravian L., Ariese, Hendrikus C. R., Wehrens, Ellen J., Dekkers, Johanna F., Rios, Anne C.

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A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery von Jeremiasse, Bernadette, van Ineveld, Ravian L, Bok, Veerle, Kleinnijenhuis, Michiel, de Blank, Sam, Alieva, Maria, Johnson, Hannah R, van Vliet, Esmée J, Zeeman, Amber L, Wellens, Lianne M, Llibre-Palomar, Gerard, Barrera Román, Mario, Di Maggio, Alessia, Dekkers, Johanna F, Oliveira, Sabrina, Vahrmeijer, Alexander L, Molenaar, Jan J, Wijnen, Marc HWA, van der Steeg, Alida FW, Wehrens, Ellen J, Rios, Anne C

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3D imaging for driving cancer discovery von van Ineveld, Ravian L, van Vliet, Esmée J, Wehrens, Ellen J, Alieva, Maria, Rios, Anne C

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Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging von Rios, Anne C., Capaldo, Bianca D., Vaillant, François, Pal, Bhupinder, van Ineveld, Ravian, Dawson, Caleb A., Chen, Yunshun, Nolan, Emma, Fu, Nai Yang, Jackling, Felicity C., Devi, Sapna, Clouston, David, Whitehead, Lachlan, Smyth, Gordon K., Mueller, Scott N., Lindeman, Geoffrey J., Visvader, Jane E.

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Snake Venom Gland Organoids von Post, Yorick, Puschhof, Jens, Beumer, Joep, Kerkkamp, Harald M., de Bakker, Merijn A.G., Slagboom, Julien, de Barbanson, Buys, Wevers, Nienke R., Spijkers, Xandor M., Olivier, Thomas, Kazandjian, Taline D., Ainsworth, Stuart, Iglesias, Carmen Lopez, van de Wetering, Willine J., Heinz, Maria C., van Ineveld, Ravian L., van Kleef, Regina G.D.M., Begthel, Harry, Korving, Jeroen, Bar-Ephraim, Yotam E., Getreuer, Walter, Rios, Anne C., Westerink, Remco H.S., Snippert, Hugo J.G., van Oudenaarden, Alexander, Peters, Peter J., Vonk, Freek J., Kool, Jeroen, Richardson, Michael K., Casewell, Nicholas R., Clevers, Hans

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An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity von Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L., Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H. D., Visser, Lindy L., Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A. M., Kemmeren, Patrick, de Krijger, Ronald R., Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., van Boxtel, Ruben, Holstege, Frank C. P., Clevers, Hans, Drost, Jarno

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Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D von van Ineveld, Ravian L., Collot, Raphaël, Román, Mario Barrera, Pagliaro, Anna, Bessler, Nils, Ariese, Hendrikus C. R., Kleinnijenhuis, Michiel, Kool, Marcel, Alieva, Maria, Chuva de Sousa Lopes, Susana M., Wehrens, Ellen J., Rios, Anne C.

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Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D von van Ineveld, Ravian L., Kleinnijenhuis, Michiel, Alieva, Maria, de Blank, Sam, Barrera Roman, Mario, van Vliet, Esmée J., Martínez Mir, Clara, Johnson, Hannah R., Bos, Frank L., Heukers, Raimond, Chuva de Sousa Lopes, Susana M., Drost, Jarno, Dekkers, Johanna F., Wehrens, Ellen J., Rios, Anne C.

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LGR6 marks nephron progenitor cells von Ineveld, Ravian L., Margaritis, Thanasis, Kooiman, Berend A.P., Groenveld, Femke, Ariese, Hendrikus C.R., Lijnzaad, Philip, Johnson, Hannah R., Korving, Jeroen, Wehrens, Ellen J., Holstege, Frank, Rheenen, Jacco, Drost, Jarno, Rios, Anne C., Bos, Frank L.

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Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging von Rios, Anne C, Capaldo, Bianca D, Vaillant, François, Pal, Bhupinder, van Ineveld, Ravian, Dawson, Caleb A, Chen, Yunshun, Nolan, Emma, Fu, Nai Yang, Jackling, Felicity C, Devi, Sapna, Clouston, David, Whitehead, Lachlan, Smyth, Gordon K, Mueller, Scott N, Lindeman, Geoffrey J, Visvader, Jane E

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Rapid tissue prototyping with micro-organospheres von Wang, Zhaohui, Boretto, Matteo, Millen, Rosemary, Natesh, Naveen, Reckzeh, Elena S., Hsu, Carolyn, Negrete, Marcos, Yao, Haipei, Quayle, William, Heaton, Brook E., Harding, Alfred T., Bose, Shree, Driehuis, Else, Beumer, Joep, Rivera, Grecia O., van Ineveld, Ravian L., Gex, Donald, DeVilla, Jessica, Wang, Daisong, Puschhof, Jens, Geurts, Maarten H., Yeung, Athena, Hamele, Cait, Smith, Amber, Bankaitis, Eric, Xiang, Kun, Ding, Shengli, Nelson, Daniel, Delubac, Daniel, Rios, Anne, Abi-Hachem, Ralph, Jang, David, Goldstein, Bradley J., Glass, Carolyn, Heaton, Nicholas S., Hsu, David, Clevers, Hans, Shen, Xiling

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Single‐cell RNA sequencing of pediatric Hodgkin lymphoma to study the inhibition of T cell subtypes von Kanter, Jurrian K., Steemers, Alexander S., Gonzalez, Daniel Montiel, Ineveld, Ravian L., Blijleven, Catharina, Groenen, Niels, Trabut, Laurianne, Scheijde‐Vermeulen, Marijn A., Westera, Liset, Beishuizen, Auke, Rios, Anne C., Holstege, Frank C. P., Brandsma, Arianne M., Margaritis, Thanasis, Boxtel, Ruben, Meyer‐Wentrup, Friederike

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Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids von van Ineveld, Ravian L., Ariese, Hendrikus C.R., Wehrens, Ellen J., Dekkers, Johanna F., Rios, Anne C.

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Uncovering the mode of action of engineered T cells in patient cancer organoids von Dekkers, Johanna F., Alieva, Maria, Cleven, Astrid, Keramati, Farid, Wezenaar, Amber K. L., van Vliet, Esmée J., Puschhof, Jens, Brazda, Peter, Johanna, Inez, Meringa, Angelo D., Rebel, Heggert G., Buchholz, Maj-Britt, Barrera Román, Mario, Zeeman, Amber L., de Blank, Sam, Fasci, Domenico, Geurts, Maarten H., Cornel, Annelisa M., Driehuis, Else, Millen, Rosemary, Straetemans, Trudy, Nicolasen, Mara J. T., Aarts-Riemens, Tineke, Ariese, Hendrikus C. R., Johnson, Hannah R., van Ineveld, Ravian L., Karaiskaki, Froso, Kopper, Oded, Bar-Ephraim, Yotam E., Kretzschmar, Kai, Eggermont, Alexander M. M., Nierkens, Stefan, Wehrens, Ellen J., Stunnenberg, Henk G., Clevers, Hans, Kuball, Jürgen, Sebestyen, Zsolt, Rios, Anne C.

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LGR6 marks nephron progenitor cells von van Ineveld, Ravian L, Margaritis, Thanasis, Kooiman, Berend A.P, Groenveld, Femke, Ariese, Hendrikus C.R, Lijnzaad, Philip, Johnson, Hannah R, Korving, Jeroen, Wehrens, Ellen J, Holstege, Frank, van Rheenen, Jacco, Drost, Jarno, Rios, Anne C, Bos, Frank L

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Cover Image von van Ineveld, Ravian L., Margaritis, Thanasis, Kooiman, Berend A.P., Groenveld, Femke, Ariese, Hendrikus C.R., Lijnzaad, Philip, Johnson, Hannah R., Korving, Jeroen, Wehrens, Ellen J., Holstege, Frank, van Rheenen, Jacco, Drost, Jarno, Rios, Anne C., Bos, Frank L.

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BIOL-14. FROM NON-MALIGNANT TO MALIGNANT: GENERATING AND TARGETING DIFFUSE MIDLINE GLIOMA IN A NOVEL HUMAN PONTINE ORGANOID MODEL von Bessler, Nils, Moreno, Cristian Ruiz, Wezenaar, Amber, Dommann, Noëlle, Keramati, Farid, Ariese, Hendrikus C R, Honhoff, Celina, de Blank, Sam, Román, Mario Barrera, Collot, Raphaël, van Ineveld, Ravian, Krashennikova, Maria Alieva, Kranendonk, Mariette E G, Wehrens, Ellen J, Alemany, Anna, Stunnenberg, Henk G, Rios, Anne C

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Uncovering the mode of action of engineered T cells in patient cancer organoids von Dekkers, Johanna F, Alieva, Maria, Cleven, Astrid, Keramati, Farid, Wezenaar, Amber K.L, van Vliet, Esmée J, Puschhof, Jens, Brazda, Peter, Johanna, Inez, Meringa, Angelo D, Rebel, Heggert G, Buchholz, Maj Britt, Barrera Román, Mario, Zeeman, Amber L, de Blank, Sam, Fasci, Domenico, Geurts, Maarten H, Cornel, Annelisa M, Driehuis, Else, Millen, Rosemary, Straetemans, Trudy, Nicolasen, Mara J.T, Aarts-Riemens, Tineke, Ariese, Hendrikus C.R, Johnson, Hannah R, van Ineveld, Ravian L, Karaiskaki, Froso, Kopper, Oded, Bar-Ephraim, Yotam E, Kretzschmar, Kai, Eggermont, Alexander M.M, Nierkens, Stefan, Wehrens, Ellen J, Stunnenberg, Henk G, Clevers, Hans, Kuball, Jürgen, Sebestyen, Zsolt, Rios, Anne C

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Abstract IA27: Patient-derived organoids in pediatric cancer research von Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian, Derakhshan, Sepideh, Custers, Lars, Lijnzaad, Philip, Begthel, Harry, Kerstens, Hinri, Rookmaker, Maarten, Verhaar, Marianne, Kemmeren, Patrick, de Krijger, Ronald, Pritchard-Jones, Kathy, Rios, Anne, van den Heuvel-Eibrink, Marry, Holstege, Frank, van Boxtel, Ruben, Clevers, Hans, Drost, Jarno

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