A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom–Up and Top–Down approaches von Scott, Laurie, Eskes, Chantra, Hoffmann, Sebastian, Adriaens, Els, Alepée, Nathalie, Bufo, Monica, Clothier, Richard, Facchini, Davide, Faller, Claudine, Guest, Robert, Harbell, John, Hartung, Thomas, Kamp, Hennicke, Varlet, Béatrice Le, Meloni, Marisa, McNamee, Pauline, Osborne, Rosemarie, Pape, Wolfgang, Pfannenbecker, Uwe, Prinsen, Menk, Seaman, Christopher, Spielmann, Horst, Stokes, William, Trouba, Kevin, Berghe, Christine Van den, Goethem, Freddy Van, Vassallo, Marco, Vinardell, Pilar, Zuang, Valérie

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Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates? von Mesens, Natalie, Crawford, Alexander D., Menke, Aswin, Hung, Pham Duc, Van Goethem, Freddy, Nuyts, Rik, Hansen, Erik, Wolterbeek, Andre, Van Gompel, Jacky, De Witte, Peter, Esguerra, Camila V.

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Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy von Verbist, Bie M. P, Verheyen, Geert R, Vervoort, Liesbet, Crabbe, Marjolein, Beerens, Dominiek, Bosmans, Cindy, Jaensch, Steffen, Osselaer, Steven, Talloen, Willem, Van den Wyngaert, Ilse, Van Hecke, Geert, Wuyts, Dirk, Van Goethem, Freddy, Göhlmann, Hinrich W. H

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Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay von Bryce, Steven M., Avlasevich, Svetlana L., Bemis, Jeffrey C., Lukamowicz, Magdalena, Elhajouji, Azeddine, Van Goethem, Freddy, De Boeck, Marlies, Beerens, Dominiek, Aerts, Hilde, Van Gompel, Jacky, Collins, Joanne E., Ellis, Patricia C., White, Angela T., Lynch, Anthony M., Dertinger, Stephen D.

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Integrating transcriptomic profiling in early safety screening – A case study von Van Goethem, Freddy

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Screening for phospholipidosis induced by central nervous drugs: Comparing the predictivity of an in vitro assay to high throughput in silico assays von Mesens, Natalie, Steemans, Margino, Hansen, Erik, Verheyen, Geert R., Van Goethem, Freddy, Van Gompel, Jaques

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The evolving role of investigative toxicology in the pharmaceutical industry von Pognan, Francois, Beilmann, Mario, Boonen, Harrie C. M., Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Oinonen, Teija, Roth, Adrian, Steger-Hartmann, Thomas, Valentin, Jean-Pierre, Van Goethem, Freddy, Weaver, Richard J., Newham, Peter

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Comparative evaluation of the in vitro micronucleus test and the alkaline single cell gel electrophoresis assay for the detection of DNA damaging agents: genotoxic effects of cobal... von Van Goethem, Freddy, Lison, Dominique, Kirsch-Volders, Micheline

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AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules von Rao, Mohan, Nassiri, Vahid, Alhambra, Cristóbal, Snoeys, Jan, Van Goethem, Freddy, Irrechukwu, Onyi, Aleo, Michael D., Geys, Helena, Mitra, Kaushik, Will, Yvonne

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Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling von De Boeck, Marlies, van der Leede, Bas-jan, Van Goethem, Freddy, De Smedt, Ann, Steemans, Margino, Lampo, Ann, Vanparys, Philippe

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Optimizing drug discovery by Investigative Toxicology: Current and future trends von Beilmann, Mario, Boonen, Harrie, Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Newham, Peter, Oinonen, Teija, Pognan, Francois, Roth, Adrian, Valentin, Jean-Pierre, Van Goethem, Freddy, Weaver, Richard J, Birk, Barbara, Boyer, Scott, Caloni, Francesca, Chen, Alice E, Corvi, Raffaella, Cronin, Mark T D, Daneshian, Mardas, Ewart, Lorna C, Fitzgerald, Rex E, Hamilton, Geraldine A, Hartung, Thomas, Kangas, Joshua D, Kramer, Nynke I, Leist, Marcel, Marx, Uwe, Polak, Sebastian, Rovida, Costanza, Testai, Emanuela, Van der Water, Bob, Vulto, Paul, Steger-Hartmann, Thomas

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Analysis of negative historical control group data from the in vitro micronucleus assay using TK6 cells von Lovell, David P., Fellows, Mick, Marchetti, Francesco, Christiansen, Joan, Elhajouji, Azeddine, Hashimoto, Kiyohiro, Kasamoto, Sawako, Li, Yan, Masayasu, Ozaki, Moore, Martha M., Schuler, Maik, Smith, Robert, Stankowski, Leon F., Tanaka, Jin, Tanir, Jennifer Y., Thybaud, Veronique, Van Goethem, Freddy, Whitwell, James

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Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: Protocol optimization and transferability assessment von Bryce, Steven M., Avlasevich, Svetlana L., Bemis, Jeffrey C., Tate, Matthew, Walmsley, Richard M., Saad, Frédéric, Van Dijck, Kris, De Boeck, Marlies, Van Goethem, Freddy, Lukamowicz-Rajska, Magdalena, Elhajouji, Azeddine, Dertinger, Stephen D.

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Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future von Avlasevich, Svetlana, Bryce, Steven, De Boeck, Marlies, Elhajouji, Azeddine, Van Goethem, Freddy, Lynch, Anthony, Nicolette, John, Shi, Jing, Dertinger, Stephen

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Follow-up actions from positive results of in vitro genetic toxicity testing von Dearfield, Kerry L, Thybaud, Véronique, Cimino, Michael C, Custer, Laura, Czich, Andreas, Harvey, James S, Hester, Susan, Kim, James H, Kirkland, David, Levy, Dan D, Lorge, Elisabeth, Moore, Martha M, Ouédraogo-Arras, Gladys, Schuler, Maik, Suter, Willi, Sweder, Kevin, Tarlo, Kirk, van Benthem, Jan, van Goethem, Freddy, Witt, Kristine L

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Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates? von Mesens, Natalie, Crawford, Alexander D, Menke, Aswin, Pham, Duc Hung, Van Goethem, Freddy, Nuyts, Rik, Hansen, Erik, Wolterbeek, Andre, Van Gompel, Jacky, de Witte, Peter, Esguerra, Camila V

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Mouse lymphoma thymidine kinase gene mutation assay: Follow-up meeting of the international workshop on Genotoxicity testing-Aberdeen, Scotland, 2003-Assay acceptance criteria, pos... von Moore, Martha M., Honma, Masamitsu, Clements, Julie, Bolcsfoldi, George, Burlinson, Brian, Cifone, Maria, Clarke, Jane, Delongchamp, Robert, Durward, Robert, Fellows, Michael, Gollapudi, Bhaskar, Hou, Saimei, Jenkinson, Peter, Lloyd, Melvin, Majeska, Jenness, Myhr, Brian, O'Donovan, Michael, Omori, Takashi, Riach, Colin, San, Richard, Stankowski Jr, Leon F., Thakur, Ajit K., Van Goethem, Freddy, Wakuri, Shinobu, Yoshimura, Isao

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Development of a new opacitometer for the bovine corneal opacity and permeability (BCOP) assay von Van Goethem, Freddy, Hansen, Erik, Sysmans, Marc, De Smedt, Ann, Vanparys, Philippe, Van Gompel, Jacky

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Optimizing drug discovery by Investigative Toxicology: Current and future trends von Beilmann, Mario, Boonen, Harrie, Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Newham, Peter, Oinonen, Teija, Pognan, Francois, Roth, Adrian, Valentin, Jean-Pierre, Van Goethem, Freddy, Weaver, Richard J, Birk, Barbara, Boyer, Scott, Caloni, Francesca, Chen, Alice E, Corvi, Raffaella, Cronin, Mark T D, Daneshian, Mardas, Ewart, Lorna C, Fitzgerald, Rex E, Hamilton, Geraldine A, Hartung, Thomas, Kangas, Joshua D, Kramer, Nynke I, Leist, Marcel, Marx, Uwe, Polak, Sebastian, Rovida, Costanza, Testai, Emanuela, Van der Water, Bob, Vulto, Paul, Steger-Hartmann, Thomas

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Suitable top concentration for tests with mammalian cells: Mouse lymphoma assay workgroup von Moore, Martha M., Honma, Masamitsu, Clements, Julie, Awogi, Takumi, Douglas, George R., van Goethem, Freddy, Gollapudi, Bhaskar, Kimura, Aoi, Muster, Wolfgang, O’Donovan, Mike, Schoeny, Rita, Wakuri, Shinobu

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