Drug Repurposing Using Deep Embeddings of Gene Expression Profiles von Donner, Yoni, Kazmierczak, Stéphane, Fortney, Kristen

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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19 von Wong, Lok-Yin Roy, Zheng, Jian, Wilhelmsen, Kevin, Li, Kun, Ortiz, Miguel E., Schnicker, Nicholas J., Thurman, Andrew, Pezzulo, Alejandro A., Szachowicz, Peter J., Li, Pengfei, Pan, Ruangang, Klumpp, Klaus, Aswad, Fred, Rebo, Justin, Narumiya, Shuh, Murakami, Makoto, Zuniga, Sonia, Sola, Isabel, Enjuanes, Luis, Meyerholz, David K., Fortney, Kristen, McCray, Paul B., Perlman, Stanley

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Network-based characterization of drug-regulated genes, drug targets, and toxicity von Kotlyar, Max, Fortney, Kristen, Jurisica, Igor

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Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity von Fortney, Kristen, Dobriban, Edgar, Garagnani, Paolo, Pirazzini, Chiara, Monti, Daniela, Mari, Daniela, Atzmon, Gil, Barzilai, Nir, Franceschi, Claudio, Owen, Art B, Kim, Stuart K

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The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae von Bhalla, Manmeet, Herring, Sydney, Lenhard, Alexsandra, Wheeler, Joshua R, Aswad, Fred, Klumpp, Klaus, Rebo, Justin, Wang, Yan, Wilhelmsen, Kevin, Fortney, Kristen, Bou Ghanem, Elsa N

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Integrative computational biology for cancer research von Fortney, Kristen, Jurisica, Igor

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118-OR: The Apelin Receptor Agonist Azelaprag Increases Weight Loss in Diet-Induced Obese Mice on Incretin Agonists and Restores Body Composition and Muscle Function to That of Lea... von Wang, Yan, Yan, Shijun, Banicki, Matthew, Cochran, Mary, Portillo, Claudia, Guerrero, Gabriel, Pan, Yong, Cowdin, Samantha, Patil, Christopher, Rebo, Justin, Hughes, Robert, Montgomery, Rusty, Morgen, Eric, tney, Kristen, Rubin, Paul

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Validation of biomarkers of aging von Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R., Ying, Kejun, Justice, Jamie N., Belsky, Daniel W., Higgins-Chen, Albert T., Chen, Brian H., Cohen, Alan A., Fuellen, Georg, Hägg, Sara, Marioni, Riccardo E., Widschwendter, Martin, Fortney, Kristen, Fedichev, Peter O., Zhavoronkov, Alex, Barzilai, Nir, Lasky-Su, Jessica, Kiel, Douglas P., Kennedy, Brian K., Cummings, Steven, Slagboom, P. Eline, Verdin, Eric, Maier, Andrea B., Sebastiano, Vittorio, Snyder, Michael P., Gladyshev, Vadim N., Horvath, Steve, Ferrucci, Luigi

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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening von Hartman, George, Humphries, Paul, Hughes, Robert, Ho, Andrew, Montgomery, Rusty, Deshpande, Aditi, Mahanta, Maitriyee, Tronnes, Sarah, Cowdin, Samantha, He, Xu, Liu, Fangchao, Zhang, Lifang, Liu, Chuan, Dou, Dengfeng, Li, Jin, Spasic, Aleksander, Coll, Rebecca, Marleaux, Michael, Hochheiser, Inga V., Geyer, Matthias, Rubin, Paul, Fortney, Kristen, Wilhelmsen, Kevin

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Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging von Fortney, Kristen, Kotlyar, Max, Jurisica, Igor

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Circulating glucuronic acid predicts healthspan and longevity in humans and mice von Ho, Andrew, Sinick, Jonah, Esko, Tõnu, Fischer, Krista, Menni, Cristina, Zierer, Jonas, Matey-Hernandez, Maria, Fortney, Kristen, Morgen, Eric K

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Defining a longevity biotechnology company von Boekstein, Nicola, Barzilai, Nir, Bertram, André, Betts-LaCroix, Joe, Fortney, Kristen, Helliwell, Stephen B., Hufford, Michael, Mannick, Joan, McLaughlin, Jerry, Mellon, Jim, Morgen, Eric, Regge, Nils, Robinton, Daisy A., Sinclair, David A., Young, Sergey, Starr, Risa, Zhavoronkov, Alex, Peyer, James

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Optimal multiple testing under a Gaussian prior on the effect sizes von DOBRIBAN, EDGAR, FORTNEY, KRISTEN, KIM, STUART K., OWEN, ART B.

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Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome von Hsu, Yu-Han H., Astley, Christina M., Cole, Joanne B., Vedantam, Sailaja, Mercader, Josep M., Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K., Gonzalez, Clicerio, Gonzalez, Maria E., Esko, Tonu, Hirschhorn, Joel N.

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Prioritizing therapeutics for lung cancer: an integrative meta-analysis of cancer gene signatures and chemogenomic data von Fortney, Kristen, Griesman, Joshua, Kotlyar, Max, Pastrello, Chiara, Angeli, Marc, Sound-Tsao, Ming, Jurisica, Igor

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Whole-genome sequencing of the world's oldest people von Gierman, Hinco J, Fortney, Kristen, Roach, Jared C, Coles, Natalie S, Li, Hong, Glusman, Gustavo, Markov, Glenn J, Smith, Justin D, Hood, Leroy, Coles, L Stephen, Kim, Stuart K

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MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality von Peto, Maximus V, De la Guardia, Carlos, Winslow, Ksenia, Ho, Andrew, Fortney, Kristen, Morgen, Eric

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Computational Advantages of Reverberating Loops for Sensorimotor Learning von Fortney, Kristen, Tweed, Douglas B.

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PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data von Hsu, Yu-Han H, Churchhouse, Claire, Pers, Tune H, Mercader, Josep M, Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K, Gonzalez, Clicerio, Gonzalez, Maria E, Esko, Tonu, Hirschhorn, Joel N

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NetwoRx: connecting drugs to networks and phenotypes in Saccharomyces cerevisiae von Fortney, Kristen, Xie, Wing, Kotlyar, Max, Griesman, Joshua, Kotseruba, Yulia, Jurisica, Igor

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