Combinatorial optimization of the hybrid cellulase complex structure designed from modular libraries von Nakazawa, Hikaru, Okada, Izumi, Ito, Tomoyuki, Ishigaki, Yuri, Kumagai, Izumi, Umetsu, Mitsuo

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Engineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance von Suzuki, Saori, Annaka, Hiroaki, Konno, Shota, Kumagai, Izumi, Asano, Ryutaro

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Construction of IgG–Fab2 bispecific antibody via intein-mediated protein trans-splicing reaction von Yamada, Risa, Nakahara, Ishin, Kumagai, Izumi, Asano, Ryutaro, Nakanishi, Takeshi, Makabe, Koki

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Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope von Makabe, Koki, Yokoyama, Takeshi, Uehara, Shiro, Uchikubo-Kamo, Tomomi, Shirouzu, Mikako, Kimura, Kouki, Tsumoto, Kouhei, Asano, Ryutaro, Tanaka, Yoshikazu, Kumagai, Izumi

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Functional Domain Order of an Anti-EGFR × Anti-CD16 Bispecific Diabody Involving NK Cell Activation von Kuwahara, Atsushi, Nagai, Keisuke, Nakanishi, Takeshi, Kumagai, Izumi, Asano, Ryutaro

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Construction of a circularly connected VHH bispecific antibody (cyclobody) for the desirable positioning of antigen-binding sites von Hemmi, Saki, Asano, Ryutaro, Kimura, Kouki, Umetsu, Mitsuo, Nakanishi, Takeshi, Kumagai, Izumi, Makabe, Koki

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Structural Basis for Recognition of the Nonclassical MHC Molecule HLA-G by the Leukocyte Ig-Like Receptor B2 (LILRB2/LIR2/ILT4/CD85d) von Shiroishi, Mitsunori, Kuroki, Kimiko, Rasubala, Linda, Tsumoto, Kouhei, Kumagai, Izumi, Kurimoto, Eiji, Kato, Koichi, Kohda, Daisuke, Maenaka, Katsumi

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Complementary Design for Pairing between Two Types of Nanoparticles Mediated by a Bispecific Antibody: Bottom-Up Formation of Porous Materials from Nanoparticles von Niide, Teppei, Manabe, Noriyoshi, Nakazawa, Hikaru, Akagi, Kazuto, Hattori, Takamitsu, Kumagai, Izumi, Umetsu, Mitsuo

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Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats von Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi

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Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units von Yoshida, Jyunna, Kato, Yuki, Isogawa, Ai, Tanaka, Yoshikazu, Kumagai, Izumi, Asano, Ryutaro, Nakanishi, Takeshi, Makabe, Koki

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Impact in stability during sequential CDR grafting to construct camelid VHH antibodies against zinc oxide and gold von Saito, Ryota, Saito, Yutaro, Nakazawa, Hikaru, Hattori, Takamitsu, Kumagai, Izumi, Umetsu, Mitsuo, Makabe, Koki

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Electrochemical Detection of Epidermal Growth Factor Receptors on a Single Living Cell Surface by Scanning Electrochemical Microscopy von Takahashi, Yasufumi, Miyamoto, Takeshi, Shiku, Hitoshi, Asano, Ryutaro, Yasukawa, Tomoyuki, Kumagai, Izumi, Matsue, Tomokazu

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Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus von Uchida, Hiroaki, Marzulli, Marco, Nakano, Kenji, Goins, William F, Chan, Janet, Hong, Chang-Sook, Mazzacurati, Lucia, Yoo, Ji Young, Haseley, Amy, Nakashima, Hiroshi, Baek, Hyunjung, Kwon, Heechung, Kumagai, Izumi, Kuroki, Masahide, Kaur, Balveen, Chiocca, E Antonio, Grandi, Paola, Cohen, Justus B, Glorioso, Joseph C

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High-throughput cytotoxicity and antigen-binding assay for screening small bispecific antibodies without purification von Sugiyama, Aruto, Umetsu, Mitsuo, Nakazawa, Hikaru, Niide, Teppei, Asano, Ryutaro, Hattori, Takamitsu, Kumagai, Izumi

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Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity von Asano, Ryutaro, Nagai, Keisuke, Makabe, Koki, Takahashi, Kento, Kumagai, Takashi, Kawaguchi, Hiroko, Ogata, Hiromi, Arai, Kyoko, Umetsu, Mitsuo, Kumagai, Izumi

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Chemically Crosslinked Bispecific Antibodies for Cancer Therapy: Breaking from the Structural Restrictions of the Genetic Fusion Approach von Ueda, Asami, Umetsu, Mitsuo, Nakanishi, Takeshi, Hashikami, Kentaro, Nakazawa, Hikaru, Hattori, Shuhei, Asano, Ryutaro, Kumagai, Izumi

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A semi high-throughput method for screening small bispecific antibodies with high cytotoxicity von Sugiyama, Aruto, Umetsu, Mitsuo, Nakazawa, Hikaru, Niide, Teppei, Onodera, Tomoko, Hosokawa, Katsuhiro, Hattori, Shuhei, Asano, Ryutaro, Kumagai, Izumi

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Practical considerations in refolding proteins from inclusion bodies von Tsumoto, Kouhei, Ejima, Daisuke, Kumagai, Izumi, Arakawa, Tsutomu

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Association behavior and control of the quality of cancer therapeutic bispecific diabodies expressed in Escherichia coli von Nakazawa, Hikaru, Onodera-Sugano, Tomoko, Sugiyama, Aruto, Tanaka, Yoshikazu, Hattori, Takamitsu, Niide, Teppei, Ogata, Hiromi, Asano, Ryutaro, Kumagai, Izumi, Umetsu, Mitsuo

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A High-Affinity Gold-Binding Camel Antibody: Antibody Engineering for One-Pot Functionalization of Gold Nanoparticles as Biointerface Molecules von Hattori, Takamitsu, Umetsu, Mitsuo, Nakanishi, Takeshi, Sawai, Satoko, Kikuchi, Shinsuke, Asano, Ryutaro, Kumagai, Izumi

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