Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting von Rensen, Patrick C.N, de Vrueh, Remco L.A, Kuiper, Johan, Bijsterbosch, Martin K, Biessen, Erik A.L, van Berkel, Theo J.C

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Safety-Related Regulatory Actions for Orphan Drugs in the US and EU: A Cohort Study von Heemstra, Harald E., Giezen, Thijs J., Mantel-Teeuwisse, Aukje K., de Vrueh, Remco L. A., Leufkens, Hubert G. M.

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Reflections on the Future of Pharmaceutical Public-Private Partnerships: From Input to Impact von de Vrueh, Remco L. A., Crommelin, Daan J. A.

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Translation of rare disease research into orphan drug development: disease matters von Heemstra, Harald E., van Weely, Sonja, Büller, Hans A., Leufkens, Hubert G.M., de Vrueh, Remco L.A.

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Editorial: Public-Private Partnerships as Drivers of Innovation in Healthcare von de Vrueh, Remco L A, de Vlieger, Jon S B, Crommelin, Daan J A

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Drug development for exceptionally rare metabolic diseases: challenging but not impossible von Putzeist, Michelle, Mantel-Teeuwisse, Aukje K, Wied, Christine C Gispen-de, Hoes, Arno W, Leufkens, Hubert G M, de Vrueh, Remco L A

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5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter von HAN, H.-K, DE VRUEH, R. L. A, RHIE, J. K, COVITZ, K.-M. Y, SMITH, P. L, LEE, C.-P, OH, D.-M, SADEE, W, AMIDON, G. L

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Orphan drug development across Europe: bottlenecks and opportunities von Heemstra, Harald E., de Vrueh, Remco L.A., van Weely, Sonja, Büller, Hans A., Leufkens, Hubert G.M.

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Towards harmonization of outcome measures in children with mitochondrial disorders von Koene, Saskia, Jansen, Merel, Verhaak, Chris M., de Vrueh, Remco L.A., de Groot, Imelda J.M., Smeitink, Jan A.M.

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Modification of the plasma clearance and liver uptake of steroid ester-conjugated oligodeoxynucleotides by association with (lactosylated) low-density lipoprotein von Rump, Erik T, de Vrueh, Remco L.A, Manoharan, Muthiah, Waarlo, Ingrid H.E, van Veghel, Richard, Biessen, Erik A.L, van Berkel, Theo J.C, Bijsterbosch, Martin K

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Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation von Bijsterbosch, M K, Rump, E T, De Vrueh, R L, Dorland, R, van Veghel, R, Tivel, K L, Biessen, E A, van Berkel, T J, Manoharan, M

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In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells von Bijsterbosch, Martin K., Manoharan, Muthiah, Rump, Erik T., De Vrueh, Remco L. A., van Veghel, Richard, Tivel, Kathleen L., Biessen, Erik A. L., Bennett, C. Frank, Cook, P. Dan, van Berkel, Theo J. C.

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Carrier-Mediated Delivery of 9-(2-Phosphonylmethoxyethyl)Adenine to Parenchymal Liver Cells: a Novel Therapeutic Approach for Hepatitis B von DE VRUEH, R. L. A, RUMP, E. T, VAN DE BILT, E, VAN VEGHEL, R, BALZARINI, J, BIESSEN, E. A. L, VAN BERKEL, T. J. C, BIJSTERBOSCH, M. K

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Selection of development candidates based on in vitro permeability measurements von Lee, Chao-Pin, de Vrueh, Remco L.A., Smith, Philip L.

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Carrier-Mediated Delivery Improves the Efficacy of 9-(2-Phosphonylmethoxyethyl)Adenine against Hepatitis B Virus von Bijsterbosch, M K, Ying, C, de Vrueh, R L, de Clercq, E, Biessen, E A, Neyts, J, van Berkel, T J

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Preparation of Conjugates of Oligodeoxynucleotides and Lipid Structures and Their Interaction with Low-Density Lipoprotein von Rump, Erik T, de Vrueh, Remco L. A, Sliedregt, Leo A. J. M, Biessen, Erik A. L, van Berkel, Theo J. C, Bijsterbosch, Martin K

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Synthesis of a lipophilic prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its incorporation into a hepatocyte-specific lipidic carrier von DE VRUEH, R. L. A, RUMP, E. T, SLIEDREGT, L. A. J. M, BIESSEN, E. A. L, VAN BERKEL, T. J. C, BIJSTERBOSCH, M. K

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Targeting hepatitis B therapy to the liver : Clinical pharmacokinetic considerations von RENSEN, P. C. N, DE VRUEH, R. L. A, VAN BERKEL, T. J. C

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Lipophilic Derivatization of the Antiviral Drug 9-(2-Phosphonylmethoxyethyl)adenine and Its Incorporation into a Lactosylated Lipid Carrier to Improve Its Liver Uptake von de Vrueh, Remco L.A., Rump, Erik T., Biessen, Erik A.L., Balzarini, Jan, van Berkel, Theo J.C., Bijsterbosch, Martin K.

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Conjugation of Oligonucleotides with Steroid Structures and Their Interaction with the Low-Density Lipoprotein von Rump, Erik T., de Vrueh, Remco L.A., Biessen, Erik A.L., van Berkel, Theo J.C., Bijsterbosch, Martin K.

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