5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter von HAN, H.-K, DE VRUEH, R. L. A, RHIE, J. K, COVITZ, K.-M. Y, SMITH, P. L, LEE, C.-P, OH, D.-M, SADEE, W, AMIDON, G. L

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Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting von Rensen, Patrick C.N, de Vrueh, Remco L.A, Kuiper, Johan, Bijsterbosch, Martin K, Biessen, Erik A.L, van Berkel, Theo J.C

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Carrier-Mediated Delivery of 9-(2-Phosphonylmethoxyethyl)Adenine to Parenchymal Liver Cells: a Novel Therapeutic Approach for Hepatitis B von DE VRUEH, R. L. A, RUMP, E. T, VAN DE BILT, E, VAN VEGHEL, R, BALZARINI, J, BIESSEN, E. A. L, VAN BERKEL, T. J. C, BIJSTERBOSCH, M. K

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Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation von Bijsterbosch, M K, Rump, E T, De Vrueh, R L, Dorland, R, van Veghel, R, Tivel, K L, Biessen, E A, van Berkel, T J, Manoharan, M

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In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells von Bijsterbosch, Martin K., Manoharan, Muthiah, Rump, Erik T., De Vrueh, Remco L. A., van Veghel, Richard, Tivel, Kathleen L., Biessen, Erik A. L., Bennett, C. Frank, Cook, P. Dan, van Berkel, Theo J. C.

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Novel hepatotrophic prodrugs of the antiviral nucleoside 9‐(2‐phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity von Biessen, E. A. L., Valentijn, A. R. P. M., Vrueh, R. L. A., Van de Bilt, E., Sliedregt, L. A. J. M., Prince, P., Bijsterbosch, M. K., Boom, J. H., Marel, G. A., Abrahams, P. J., Berkel, T. J. C.

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Synthesis of a lipophilic prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its incorporation into a hepatocyte-specific lipidic carrier von DE VRUEH, R. L. A, RUMP, E. T, SLIEDREGT, L. A. J. M, BIESSEN, E. A. L, VAN BERKEL, T. J. C, BIJSTERBOSCH, M. K

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Carrier-Mediated Delivery Improves the Efficacy of 9-(2-Phosphonylmethoxyethyl)Adenine against Hepatitis B Virus von Bijsterbosch, M K, Ying, C, de Vrueh, R L, de Clercq, E, Biessen, E A, Neyts, J, van Berkel, T J

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Targeting hepatitis B therapy to the liver : Clinical pharmacokinetic considerations von RENSEN, P. C. N, DE VRUEH, R. L. A, VAN BERKEL, T. J. C

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Preparation of Conjugates of Oligodeoxynucleotides and Lipid Structures and Their Interaction with Low-Density Lipoprotein von Rump, Erik T, de Vrueh, Remco L. A, Sliedregt, Leo A. J. M, Biessen, Erik A. L, van Berkel, Theo J. C, Bijsterbosch, Martin K

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Cryopreservation enables long-term storage of 9-(2-Phosphonylmethoxy-ethyl)adenine prodrug-loaded reconstituted lactosylated high-density lipoprotein von DE VRUEH, Remco L. A, VAN BERKEL, Theo J. C, BIJSTERBOSCH, Martin K

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Modification of the plasma clearance and liver uptake of steroid ester-conjugated oligodeoxynucleotides by association with (lactosylated) low-density lipoprotein von Rump, Erik T, de Vrueh, Remco L.A, Manoharan, Muthiah, Waarlo, Ingrid H.E, van Veghel, Richard, Biessen, Erik A.L, van Berkel, Theo J.C, Bijsterbosch, Martin K

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Selection of development candidates based on in vitro permeability measurements: In vitro models for selection of development candidates von LEE, C.-P, DE VRUEH, R. L. A, SMITH, P. L

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Preclinical and Clinical In Vitro In Vivo Correlation of an hGH Dextran Microsphere Formulation von VLUGT-WENSINK, K. D. F, DE VRUEH, R, GRESNIGT, M. G, HOOGERBRUGGE, C. M, VAN BUUL-OFFERS, S. C, DE LEEDE, L. G. J, STERKMAN, L. G. W, CROMMELIN, D. J. A, HENNINK, W. E, VERRIJK, R

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