Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients von Khanna, Swati, Graef, Suzanne, Mussai, Francis, Thomas, Anish, Wali, Neha, Yenidunya, Bahar Guliz, Yuan, Constance, Morrow, Betsy, Zhang, Jingli, Korangy, Firouzeh, Greten, Tim F, Steinberg, Seth M, Stetler-Stevenson, Maryalice, Middleton, Gary, De Santo, Carmela, Hassan, Raffit

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B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo von Barral, Patricia, Eckl-Dorna, Julia, Harwood, Naomi E, De Santo, Carmela, Salio, Mariolina, Illarionov, Petr, Besra, Gurdyal S, Cerundolo, Vincenzo, Batista, Facundo D

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Derangement of immune responses by myeloid suppressor cells von SERAFINI, Paolo, DE SANTO, Carmela, MARIGO, Ilaria, CINGARLINI, Sara, DOLCETTI, Luigi, GALLINA, Giovanna, ZANOVELLO, Paola, BRONTE, Vincenzo

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712 IMPORT-201 (IMP-MEL): a phase 1 first-in-human dose finding/randomized phase 2 study of a novel iNKT agonist (PORT-2) and pembrolizumab for advanced melanoma and non-small cell... von Coupe, Nicholas, Pinato, David J, Fairchild, Justin, Poe, Russell, Browne, Carri, Innaimo, Steven, Thompson, David, Gileadi, Uzi, Santo, Carmela De, Kramer, Robert, Walters, Ian, Middleton, Mark R

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Molecular basis and current strategies of therapeutic arginine depletion for cancer von Fultang, Livingstone, Vardon, Ashley, De Santo, Carmela, Mussai, Francis

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Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity von Fultang, Livingstone, Booth, Sarah, Yogev, Orli, Martins da Costa, Barbara, Tubb, Vanessa, Panetti, Silvia, Stavrou, Victoria, Scarpa, Ugo, Jankevics, Andris, Lloyd, Gavin, Southam, Andrew, Lee, Steven P., Dunn, Warwick B., Chesler, Louis, Mussai, Francis, De Santo, Carmela

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Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A von Cerundolo, Vincenzo, De Santo, Carmela, Arscott, Ramon, Booth, Sarah, Karydis, Ioannis, Jones, Margaret, Asher, Ruth, Salio, Mariolina, Middleton, Mark

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Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment von Mussai, Francis, De Santo, Carmela, Abu-Dayyeh, Issa, Booth, Sarah, Quek, Lynn, McEwen-Smith, Rosanna M., Qureshi, Amrana, Dazzi, Francesco, Vyas, Paresh, Cerundolo, Vincenzo

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Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target von Mussai, Francis, Egan, Sharon, Higginbotham-Jones, Joseph, Perry, Tracey, Beggs, Andrew, Odintsova, Elena, Loke, Justin, Pratt, Guy, U, Kin Pong, Lo, Anthony, Ng, Margaret, Kearns, Pamela, Cheng, Paul, De Santo, Carmela

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Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia von Craddock, Charles, Slade, Daniel, De Santo, Carmela, Wheat, Rachel, Ferguson, Paul, Hodgkinson, Andrea, Brock, Kristian, Cavenagh, Jamie, Ingram, Wendy, Dennis, Mike, Malladi, Ram, Siddique, Shamyla, Mussai, Francis, Yap, Christina

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Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma von De Santo, Carmela, Cheng, Paul, Beggs, Andrew, Egan, Sharon, Bessudo, Alberto, Mussai, Francis

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Characterizing EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells von Collins, Paul J., Fox, Christopher P., George, Lindsay, Pearce, Hayden, Ryan, Gordon, De Santo, Carmela, Mussai, Frances, Lewis, David, Long, Heather, Shannon-Lowe, Claire

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Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells von Gallina, Giovanna, Dolcetti, Luigi, Serafini, Paolo, De Santo, Carmela, Marigo, Ilaria, Colombo, Mario P, Basso, Giuseppe, Brombacher, Frank, Borrello, Ivan, Zanovello, Paola, Bicciato, Silvio, Bronte, Vincenzo

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Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies von Fultang, Livingstone, Gneo, Luciana, De Santo, Carmela, Mussai, Francis J.

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Nitroaspirin Corrects Immune Dysfunction in Tumor-Bearing Hosts and Promotes Tumor Eradication by Cancer Vaccination von De Santo, Carmela, Serafini, Paolo, Marigo, Ilaria, Dolcetti, Luigi, Bolla, Manlio, Del Soldato, Piero, Melani, Cecilia, Guiducci, Cristiana, Colombo, Mario P., Iezzi, Manuela, Musiani, Piero, Zanovello, Paola, Bronte, Vincenzo, Ignarro, Louis J.

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PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults von Fenwick, Nicola, Weston, Rebekah, Wheatley, Keith, Hodgson, Jodie, Marshall, Lynley, Elliott, Martin, Makin, Guy, Ng, Antony, Brennan, Bernadette, Lowis, Stephen, Adamski, Jenny, Kilday, John Paul, Cox, Rachel, Gattens, Mike, Moore, Andrew, Trahair, Toby, Ronghe, Milind, Campbell, Martin, Campbell, Helen, Williams, Molly W, Kirby, Maria, Van Eijkelenburg, Natasha, Keely, Jennifer, Scarpa, Ugo, Stavrou, Victoria, Fultang, Livingstone, Booth, Sarah, Cheng, Paul, De Santo, Carmela, Mussai, Francis

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G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment von Maneta, Ebtehag, Fultang, Livingstone, Taylor, Jemma, Pugh, Matthew, Jenkinson, William, Anderson, Graham, Coomarasamy, Arri, Kilby, Mark D, Lissauer, David M, Mussai, Francis, De Santo, Carmela

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Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy von Bokori-Brown, Monika, Metz, Jeremy, Petrov, Peter G, Mussai, Francis, De Santo, Carmela, Smart, Neil J, Saunders, Sarah, Knight, Bridget, Pastan, Ira, Titball, Richard W, Winlove, C Peter

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TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer von Gneo, Luciana, Rizkalla, Nagy, Hejmadi, Rahul, Mussai, Francis, de Santo, Carmela, Middleton, Gary

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Targeting the arginine metabolic brake enhances immunotherapy for leukaemia von Mussai, Francis, Wheat, Rachel, Sarrou, Evgenia, Booth, Sarah, Stavrou, Victoria, Fultang, Livingstone, Perry, Tracey, Kearns, Pamela, Cheng, Paul, Keeshan, Karen, Craddock, Charles, De Santo, Carmela

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