FROM THE EDITORS: MANAGING BY DESIGN von Gruber, Marc, de Leon, Nick, George, Gerard, Thompson, Paul

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Managing by Design von Gruber, Marc, de Leon, Nick, George, Gerard, Thompson, Paul

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The Ethics of Persuasive Technologies in Pervasive Industry Platforms: The Need for a Robust Management and Governance Framework von Borgefalk, Gustav, de Leon, Nick

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Service Design: Innovation for Complex Systems von Mager, Birgit, de Leon, Nick

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Getting Started with IBM WebSphere Cast Iron Cloud Integration von Carla Sadtler, Giuliano Diniz de Morais, Lars Besselmann-Hamandouche, Leonardo Rodriguez Leon, Nick Bletzer, Rajath Ramesh, Roberto Mascarenhas, Simon Dickerson

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Imaging markers for Alzheimer disease: Which vs how von Frisoni, Giovanni B, Bocchetta, Martina, Chételat, Gael, Rabinovici, Gil D, de Leon, Mony J, Kaye, Jeffrey, Reiman, Eric M, Scheltens, Philip, Barkhof, Frederik, Black, Sandra E, Brooks, David J, Carrillo, Maria C, Fox, Nick C, Herholz, Karl, Nordberg, Agneta, Jack, Clifford R, Jagust, William J, Johnson, Keith A, Rowe, Christopher C, Sperling, Reisa A, Thies, William, Wahlund, Lars-Olof, Weiner, Michael W, Pasqualetti, Patrizio, DeCarli, Charles

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Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021 von Funk, Tjede, Pharris, Anastasia, Spiteri, Gianfranco, Bundle, Nick, Melidou, Angeliki, Carr, Michael, Gonzalez, Gabriel, Garcia-Leon, Alejandro, Crispie, Fiona, O'Connor, Lois, Murphy, Niamh, Mossong, Joël, Vergison, Anne, Wienecke-Baldacchino, Anke K, Abdelrahman, Tamir, Riccardo, Flavia, Stefanelli, Paola, Di Martino, Angela, Bella, Antonino, Lo Presti, Alessandra, Casaca, Pedro, Moreno, Joana, Borges, Vítor, Isidro, Joana, Ferreira, Rita, Gomes, João Paulo, Dotsenko, Liidia, Suija, Heleene, Epstein, Jevgenia, Sadikova, Olga, Sepp, Hanna, Ikonen, Niina, Savolainen-Kopra, Carita, Blomqvist, Soile, Möttönen, Teemu, Helve, Otto, Gomes-Dias, Joana, Adlhoch, Cornelia

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Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an o... von Thatcher, Nick, Prof, Hirsch, Fred R, Prof, Luft, Alexander V, MD, Szczesna, Aleksandra, MD, Ciuleanu, Tudor E, Prof, Dediu, Mircea, MD, Ramlau, Rodryg, Prof, Galiulin, Rinat K, MD, Bálint, Beatrix, MD, Losonczy, György, Prof, Kazarnowicz, Andrzej, MD, Park, Keunchil, MD, Schumann, Christian, Prof, Reck, Martin, MD, Depenbrock, Henrik, MD, Nanda, Shivani, MS, Kruljac-Letunic, Anamarija, PhD, Kurek, Raffael, MD, Paz-Ares, Luis, MD, Socinski, Mark A, Prof

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Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects von Medina-Gomez, Carolina, Kemp, John P., Trajanoska, Katerina, Luan, Jian’an, Chesi, Alessandra, Ahluwalia, Tarunveer S., Mook-Kanamori, Dennis O., Ham, Annelies, Hartwig, Fernando P., Evans, Daniel S., Joro, Raimo, Nedeljkovic, Ivana, Zheng, Hou-Feng, Zhu, Kun, Atalay, Mustafa, Liu, Ching-Ti, Nethander, Maria, Broer, Linda, Porleifsson, Gudmar, Mullin, Benjamin H., Handelman, Samuel K., Nalls, Mike A., Jessen, Leon E., Heppe, Denise H.M., Richards, J. Brent, Wang, Carol, Chawes, Bo, Schraut, Katharina E., Amin, Najaf, Wareham, Nick, Karasik, David, Van der Velde, Nathalie, Ikram, M. Arfan, Zemel, Babette S., Zhou, Yanhua, Carlsson, Christian J., Liu, Yongmei, McGuigan, Fiona E., Boer, Cindy G., Bønnelykke, Klaus, Ralston, Stuart H., Robbins, John A., Walsh, John P., Zillikens, M. Carola, Langenberg, Claudia, Li-Gao, Ruifang, Williams, Frances M.K., Harris, Tamara B., Akesson, Kristina, Jackson, Rebecca D., Sigurdsson, Gunnar, den Heijer, Martin, van der Eerden, Bram C.J., van de Peppel, Jeroen, Spector, Timothy D., Pennell, Craig, Horta, Bernardo L., Felix, Janine F., Zhao, Jing Hua, Wilson, Scott G., de Mutsert, Renée, Bisgaard, Hans, Styrkársdóttir, Unnur, Jaddoe, Vincent W., Orwoll, Eric, Lakka, Timo A., Scott, Robert, Grant, Struan F.A., Lorentzon, Mattias, van Duijn, Cornelia M., Wilson, James F., Stefansson, Kari, Psaty, Bruce M., Kiel, Douglas P., Ohlsson, Claes, Ntzani, Evangelia, van Wijnen, Andre J., Forgetta, Vincenzo, Ghanbari, Mohsen, Logan, John G., Williams, Graham R., Bassett, J.H. Duncan, Croucher, Peter I., Evangelou, Evangelos, Uitterlinden, Andre G., Ackert-Bicknell, Cheryl L., Tobias, Jonathan H., Evans, David M., Rivadeneira, Fernando

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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies von Kaptoge, Stephen, Butterworth, Adam S, Willeit, Peter, Bolton, Thomas, Paige, Ellie, Paul, Dirk S, Bell, Steven, Astle, William, Verschuren, W M Monique, Sato, Shinichi, Njølstad, Inger, Salomaa, Veikko, Yeap, Bu B, Melander, Olle, Marmot, Michael, Dahm, Christina C, Dale, Caroline E, van der Schouw, Yvonne T, Simons, Leon A, Schoufour, Josje D, Key, Timothy J, Moreno-Iribas, Conchi, Davidson, Karina W, Taylor, James O, Wallace, Robert B, Tumino, Rosario, Linneberg, Allan, Panico, Salvatore, Nietert, Paul J, Kromhout, Daan, Kiechl, Stefan, Palli, Domenico, Huerta, José M, Karakatsani, Anna, Kühn, Tilman, Grobbee, Diederick E, Kauhanen, Jussi, Wennberg, Maria, Cushman, Mary, Cooper, Jackie A, Rodriguez, Carlos J, Shaw, Jonathan E, Voortman, Trudy, Dallongeville, Jean, Brunner, Eric J, Lazo, Mariana, Leon, David A, Smith, George Davey, Peto, Richard, Jackson, Rod, Banks, Emily, Butterworth, Adam, Warnakula, Samantha, Paige, Ellie, Bell, Steven, Astle, William, Sato, Shinichi, Veikko, Salomaa, Flecther, Astrid, Melander, Olle, Kuller, Lewis H, Koenig, Wolfgang, Casiglia, Edoardo, Arndt, Volker, Völzke, Henry, Dahm, Christina C, Dale, Caroline E, Bergmann, Manuela, Crespo, Carlos, Kaaks, Rudolf, Simons, Leon A, Lagiou, Pagona, Key, Timothy J, Rodriguez, Beatriz, Moreno-Iribas, Conchi, Davidson, Karina W, Quiros, J. Ramon, Skeie, Guri, Salomaa, Veikko, Strandberg, Timo, Nietert, Paul J, Salamanca-Fernandez, Elena, Krumholz, Harlan M, Price, Jackie, Travis, Ruth C, Kühn, Tilman, Barrett-Connor, Elizabeth, van Schoor, Natasja, Boeing, Heiner, Overvad, Kim, Kauhanen, Jussi, Forouhi, Nita, Wennberg, Maria, Brenner, Hermann, Assmann, Gerd, Trevisan, Maurizio, Gillumn, Richard F, Thompson, Simon, Ferrari, Pietro, Davey Smith, George

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Enhanced Communication Skills and C-reactive Protein Point-of-Care Testing for Respiratory Tract Infection: 3.5-year Follow-up of a Cluster Randomized Trial von Cals, Jochen W.L., MD, PhD, de Bock, Leon, MD, Beckers, Pieter-Jan H.W., MD, Francis, Nick A., MD, PhD, Hopstaken, Rogier M., MD, PhD, Hood, Kerenza, PhD, de Bont, Eefje G.P.M., MD, Butler, Christopher C., MD, Dinant, Geert-Jan, MD, PhD

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Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE von Ayton, Scott, Faux, Noel G., Bush, Ashley I.

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In vivo staging of regional amyloid deposition von Grothe, Michel J, Barthel, Henryk, Sepulcre, Jorge, Dyrba, Martin, Sabri, Osama, Teipel, Stefan J

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The Genomic Basis for Short-Term Evolution of Environmental Adaptation in Maize von Wisser, Randall J, Fang, Zhou, Holland, James B, Teixeira, Juliana E C, Dougherty, John, Weldekidan, Teclemariam, de Leon, Natalia, Flint-Garcia, Sherry, Lauter, Nick, Murray, Seth C, Xu, Wenwei, Hallauer, Arnel

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Cerebral small vessel disease genomics and its implications across the lifespan von Sargurupremraj, Muralidharan, Suzuki, Hideaki, Jian, Xueqiu, Sarnowski, Chloé, Evans, Tavia E., Eiriksdottir, Gudny, Sakaue, Saori, Terzikhan, Natalie, Zhao, Wei, Armstrong, Nicola J., Yanek, Lisa R., Kumar, Rajan B., van den Akker, Erik B., McWhirter, Rebekah E., Trompet, Stella, Mishra, Aniket, Saba, Yasaman, Satizabal, Claudia L., Beaudet, Gregory, Petit, Laurent, Tsuchida, Ami, Schilling, Sabrina, Sigurdsson, Sigurdur, Lewis, Cora E., Lopez, Oscar L., Smith, Jennifer A., Valdés Hernández, Maria C., van der Grond, Jeroen, Wright, Margaret J., Knol, Maria J., Thomson, Russell J., Le Grand, Quentin, Duperron, Marie-Gabrielle, Smith, Albert V., Schreiner, Pamela J., Evans, Denis A., Rotter, Jerome I., Beiser, Alexa S., Maniega, Susana Muñoz, Beekman, Marian, Trollor, Julian, Stott, David J., Vernooij, Meike W., Wittfeld, Katharina, Niessen, Wiro J., Soumaré, Aicha, Sidney, Stephen, Turner, Stephen T., Davies, Gail, Thalamuthu, Anbupalam, Völker, Uwe, van Buchem, Mark A., Dupuis, Josée, Bastin, Mark E., Teumer, Alexander, Amouyel, Philippe, Kwok, John B., Bülow, Robin, Deary, Ian J., Schofield, Peter R., Brodaty, Henry, Jiang, Jiyang, Tabara, Yasuharu, Setoh, Kazuya, Miyamoto, Susumu, Yoshida, Kazumichi, Nagata, Manabu, Matsuda, Fumihiko, Psaty, Bruce M., Bennett, David A., De Jager, Philip L., Mosley, Thomas H., Sachdev, Perminder S., Schmidt, Reinhold, Evangelou, Evangelos, Trégouët, David-Alexandre, Ikram, Mohammad A., DeCarli, Charles, Srikanth, Velandai K., Jukema, J. Wouter, Slagboom, Eline P., Kardia, Sharon L. R., Okada, Yukinori, Mazoyer, Bernard, Wardlaw, Joanna M., Nyquist, Paul A., Mather, Karen A., Grabe, Hans J., Schmidt, Helena, Van Duijn, Cornelia M., Gudnason, Vilmundur, Longstreth, William T., Launer, Lenore J., Lathrop, Mark, Seshadri, Sudha, Tzourio, Christophe, Adams, Hieab H., Matthews, Paul M., Fornage, Myriam, Debette, Stéphanie

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Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects von Toledo, Jon B, Zetterberg, Henrik, van Harten, Argonde C, Glodzik, Lidia, Martinez-Lage, Pablo, Bocchio-Chiavetto, Luisella, Rami, Lorena, Hansson, Oskar, Sperling, Reisa, Engelborghs, Sebastiaan, Osorio, Ricardo S, Vanderstichele, Hugo, Vandijck, Manu, Hampel, Harald, Teipl, Stefan, Moghekar, Abhay, Albert, Marilyn, Hu, William T, Monge Argilés, Jose A, Gorostidi, Ana, Teunissen, Charlotte E, De Deyn, Peter P, Hyman, Bradley T, Molinuevo, Jose L, Frisoni, Giovanni B, Linazasoro, Gurutz, de Leon, Mony J, van der Flier, Wiesje M, Scheltens, Philip, Blennow, Kaj, Shaw, Leslie M, Trojanowski, John Q

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Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis... von Bedawi, Eihab O, Stavroulias, Dionisios, Hedley, Emma, Blyth, Kevin G, Kirk, Alan, De Fonseka, Duneesha, Edwards, John G, Internullo, Eveline, Corcoran, John P, Marchbank, Adrian, Panchal, Rakesh, Caruana, Edward, Kadwani, Owais, Okiror, Lawrence, Saba, Tarek, Purohit, Manoj, Mercer, Rachel M, Taberham, Rhona, Kanellakis, Nikolaos, Condliffe, Alison M, Lewis, Leon G, Addala, Dinesh N, Asciak, Rachelle, Banka, Radhika, George, Vineeth, Hassan, Maged, McCracken, David, Sundaralingam, Anand, Wrightson, John M, Dobson, Melissa, West, Alex, Barnes, Graham, Harvey, John, Slade, Mark, Chester-Jones, Mae, Dutton, Susan, Miller, Robert F, Maskell, Nick A, Belcher, Elizabeth, Rahman, Najib M

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A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure von Yang, Zhijian, Nasrallah, Ilya M., Shou, Haochang, Wen, Junhao, Doshi, Jimit, Habes, Mohamad, Erus, Guray, Abdulkadir, Ahmed, Resnick, Susan M., Albert, Marilyn S., Maruff, Paul, Fripp, Jurgen, Morris, John C., Wolk, David A., Davatzikos, Christos

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Environment‐specific selection alters flowering‐time plasticity and results in pervasive pleiotropic responses in maize von Choquette, Nicole E., Holland, James B., Weldekidan, Teclemariam, Drouault, Justine, Leon, Natalia, Flint‐Garcia, Sherry, Lauter, Nick, Murray, Seth C., Xu, Wenwei, Wisser, Randall J.

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Standardization of analysis sets for reporting results from ADNI MRI data von Wyman, Bradley T, Harvey, Danielle J, Crawford, Karen, Bernstein, Matt A, Carmichael, Owen, Cole, Patricia E, Crane, Paul K, DeCarli, Charles, Fox, Nick C, Gunter, Jeffrey L, Hill, Derek, Killiany, Ronald J, Pachai, Chahin, Schwarz, Adam J, Schuff, Norbert, Senjem, Matthew L, Suhy, Joyce, Thompson, Paul M, Weiner, Michael, Jack, Clifford R

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