1305 Involucrin/ck1e/vitamin D receptor regulatory axis underlies evolution of human epidermis out of Africa von Hicks, A.R., Schmidt, A.D., Mathyer, M., de Guzman Strong, C.

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114 Involucrin deficiency results in decreased vitamin D receptor-mediated inflammation and Csnk1e isoform bias von Schmidt, A.D., Mathyer, M., Brettmann, E., de Guzman Strong, C.

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206 Involucrin knockout mice exhibit decreased Vitamin D receptor expression and reduced Vitamin D agonist-induced skin inflammation von Schmidt, A.D., Mathyer, M.E., Brettmann, E., de Guzman Strong, C.

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387 Environment impacts the phenotypic severity of flaky tail, MC903-induced inflammation, and dysbiosis in filaggrin-null mice von Hicks, A., Bharmal, M., Schmidt, A., Zheng, Q., Yin, C., Dimitrion, P., Mi, Q., Grice, E., Adrianto, I., de Guzman Strong, C.

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418 Population-specific calibration of the human skin barrier by recent evolution of eQTLs that modulate involucrin expression von Brettmann, E.A., Goodwin, Z., de Guzman Strong, C.

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677 Positive selection of Involucrin and Filaggrin-2 in the rapid evolution of the human EDC von Goodwin, Z., de Guzman Strong, C.

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724 Recent and independent emergences of population-specific enhancer eQTLs that modulate Involucrin gene expression for human skin barrier calibration von Brettmann, E., Goodwin, Z., Quiggle, A., de Guzman Strong, C.

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Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation von Dalal, Jasbir, Roh, Jee Hoon, Maloney, Susan E, Akuffo, Afua, Shah, Samir, Yuan, Han, Wamsley, Brie, Jones, Wendell B, de Guzman Strong, Cristina, Gray, Paul A, Holtzman, David M, Heintz, Nathaniel, Dougherty, Joseph D

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313 In vivo enhancer deletion in the EDC results in decreased proximal involucrin and Lce6a target gene expression marked by less accessible chromatin von Mathyer, M., Oh, I.Y., Matkovich, S., Quiggle, A.M., de Guzman Strong, C.

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352 Allelic series for an EDC enhancer generated by CRISPR/Cas9 genome editing identifies an enhancer requirement for proximal gene expression and efficient wound healing von Oh, I., Quiggle, A., Lewis, R., de Guzman Strong, C.

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829 The EDC enhancer 923 is required for Ivl, Smcp, and Lce6a gene expression and chromatin accessibility von Mathyer, M., Oh, I., Matkovich, S., Goodwin, Z., Lewis, R., de Guzman Strong, C.

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526 Targeted sequencing of filaggrin identifies novel loss-of-function mutations in pediatric African American patients with severe atopic dermatitis von Mathyer, M., Quiggle, A., Bayliss, S., Wong, C., Denil, S., Common, J., de Guzman Strong, C.

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461 Recent evolution for an involucrin/sperm mitochondria haplotype associated with epidermal function in modern humans von Goodwin, Z., Oh, I., Mathyer, M., Quiggle, A., de Guzman Strong, C.

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370 Functional regulatory variants for an EDC enhancer in atopic dermatitis converge on skin developmental Kruppel-like and AP1 family transcription factor binding sites von Quiggle, A., Goodwin, Z., Shemer, A., Bayliss, S., Guttman-Yassky, E., de Guzman Strong, C.

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419 GTEx-skin eQTLs and uncommon variants associated with decreased Involucrin expression are enriched with FLG LOF variants in atopic dermatitis von Schmidt, A.D., Quiggle, A.M., Zhou, L., Estrada, Y., Brettmann, E.A., Goodwin, Z., Kurcharski, A., Wong, C., Denil, S., Shemer, A., Common, J., Guttman-Yassky, E., de Guzman Strong, C.

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1295 Discovery of filaggrin loss-of-function mutations R788X in Hispanic and S3640X in African-American/Native American children with atopic dermatitis von Mathyer, M., Quiggle, A., Wong, C.X., Denil, S.L., Kumar, M., Ciliberto, H., Ramsey, K., Bayliss, S., Paller, A., Common, J.E., de Guzman Strong, C.

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Intrinsic atopic dermatitis (AD) shows similar Th2 and higher Th17 immune activation compared to extrinsic AD von Suárez-Fariñas, M, Dhingra, N, Gittler, J, Shemer, A, Cardinale, I, de Guzman Strong, C, Krueger, JG, Guttman-Yassky, E

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Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs von Matkovich, Scot J., Edwards, John R., Grossenheider, Tiffani C., de Guzman Strong, Cristina, Dorn, Gerald W.

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Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017 von Abdulkader, Rizwan Suliankatchi, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Afshin, Ashkan, Ahmadi, Alireza, Aichour, Amani Nidhal, Alam, Khurshid, Alkerwi, Ala'a, Appiah, Seth Christopher Yaw, Avokpaho, Euripide F G A, Ayala Quintanilla, Beatriz Paulina, Badali, Hamid, Behzadifar, Meysam, Biadgo, Belete, Biswas, Tuhin, Britton, Gabrielle, Burstein, Roy, Cahuana-Hurtado, Lucero, Chang, Jung-Chen, Christopher, Devasahayam J, Cooper, Leslie Trumbull, Davitoiu, Dragos Virgil, Degefa, Meaza Girma, Demtsu, Balem, Deribe, Kebede, Do, Huyen Phuc, Duken, Eyasu Ejeta, Farinha, Carla Sofia E Sá, Gallus, Silvano, Gamkrelidze, Amiran, Garcia, Gregory M, Gebre, Abadi Kahsu, Gomez, Ricardo Santiago, Gómez-Dantés, Hector, Guo, Jingwen, Guo, Yuming, Homaie Rad, Enayatollah, Isehunwa, Oluwaseyi Oluwakemi, Kengne, Andre Pascal, Khajavi, Alireza, Khan, Ejaz Ahmad, Defo, Barthelemy Kuate, Kumar, Pushpendra, Lansingh, Van C, Lee, James B, Mackay, Mark T, Mangalam, Srikanth, Martins-Melo, Francisco Rogerlândio, Masiye, Felix, McGrath, John J, Mehta, Varshil, Mengesha, Melkamu Merid, Mensah, George A, Meretoja, Atte, Miangotar, Yode, Mini, G K, Mohammad, Karzan Abdulmuhsin, Mohammadifard, Noushin, Mohammadi-Khanaposhtani, Maryam, Monasta, Lorenzo, Moradi-Lakeh, Maziar, Negoi, Ionut, Nomura, Shuhei, Oyekale, Abayomi Samuel, Parsian, Hadi, Postma, Maarten J, Poustchi, Hossein, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Razo-García, Christian, Rios-Blancas, Maria Jesus, Sabde, Yogesh Damodar, Safari-Faramani, Roya, Santric Milicevic, Milena M, Sarmiento-Suárez, Rodrigo, Saxena, Sonia, Schneider, Ione J C, Shafieesabet, Azadeh, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Shibuya, Kenji, Shigematsu, Mika, Singh, Virendra, Soares Filho, Adauto Martins, Sobhani, Soheila, Strong, Mark, Sufiyan, Mu'awiyyah Babale, Sulo, Gerhard, Tadakamadla, Santosh Kumar, Tehrani-Banihashemi, Arash, Tekle, Merhawi Gebremedhin, Tsegay, Amanuel, Usman, Muhammad Shariq, Yasin, Yasin Jemal, Zadnik, Vesna, Zamani, Mohammad, Zeleke, Mulugeta Molla

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Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease St... von Abate, Kalkidan Hassen, Adedoyin, Rufus Adesoji, Agrawal, Sutapa, Al Lami, Faris Hasan, Alabed, Samer, Aldridge, Robert William, Ali, Raghib, Aljunid, Syed M, Al-Raddadi, Rajaa, Amini, Erfan, Andrei, Catalina Liliana, Arora, Megha, Artaman, Al, Asayesh, Hamid, Assaye, Ashagre Molla, Awasthi, Ashish, Bärnighausen, Till, Benson, Jennifer, Biryukov, Stan, Brazinova, Alexandra, Chibalabala, Mirriam, Choi, Jee-Young Jasmine, Coresh, Josef, Dandona, Rakhi, Davey, Gail, Davitoiu, Dragos V, Dey, Subhojit, Diaz-Torné, Cesar, Duan, Leilei, El Bcheraoui, Charbel, Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G, Gankpé, Fortuné Gbètoho, Garcia-Basteiro, Alberto L, Gebrehiwot, Tsegaye Tewelde, Gibney, Katherine B, Goulart, Alessandra Carvalho, John, Oommen, Karimi, Seyed M, Kassaw, Nigussie Assefa, Kemp, Andrew Haddon, Khalil, Ibrahim A, Khosravi, Mohammad Hossein, Krohn, Kristopher J, Kuate Defo, Barthelemy, Lager, Anton Carl Jonas, Laxmaiah, Avula, Li, Yongmei, Lorkowski, Stefan, Macarayan, Erlyn RachelleKing, Magis-Rodriguez, Carlos, Malhotra, Rajesh, Mantovani, Lorenzo G, Mapoma, Chabila C, Maulik, Pallab K, Meretoja, Tuomo J, Mezgebe, Haftay Berhane, Misganaw, Awoke, Mohammad, Karzan Abdulmuhsin, Mohanty, Sanjay K, Moraga, Paula, Nanda, Lipika, Nisar, Muhammad Imran, O'Donnell, Martin J, Obermeyer, Carla Makhlouf, Panda-Jonas, Songhomitra, Parsaeian, Mahboubeh, Patton, George C, Petzold, Max, Pishgar, Farhad, Polinder, Suzanne, Poulton, Richie G, Qorbani, Mostafa, Rahman, Mahfuzar, Rajsic, Sasa, Ribeiro, Antonio L, Rokni, Mohammad Bagher, Ronfani, Luca, Rothenbacher, Dietrich, Ruhago, George Mugambage, Samy, Abdallah M, Santos, Itamar S, Santric Milicevic, Milena M, Seedat, Soraya, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shibuya, Kenji, Silveira, Dayane Gabriele Alves, Stöckl, Heidi, Sunguya, Bruno F, Tadese, Fentaw, Terkawi, Abdullah Sulieman, Tesssema, Belay, Thompson, Alex H, Tortajada, Miguel, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Wijeratne, Tissa, Yan, Lijing L, Zeeb, Hajo

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