Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells von Hof, Willemien F J, Visser, Miranda, de Jong, Joyce J, Rajasekar, Marian N, Schuringa, Jan Jacob, de Graaf, Inge A M, Touw, Daan J, Dekkers, Bart G J

Volltext

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N‑Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group von Muenzner, Julienne K, Rehm, Tobias, Biersack, Bernhard, Casini, Angela, de Graaf, Inge A. M, Worawutputtapong, Pawida, Noor, Awal, Kempe, Rhett, Brabec, Viktor, Kasparkova, Jana, Schobert, Rainer

Volltext

Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study von Estrada‐Ortiz, Natalia, Guarra, Federica, de Graaf, Inge A. M., Marchetti, Lorella, de Jager, Marina H., Groothuis, Geny M. M., Gabbiani, Chiara, Casini, Angela

Volltext

On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent von Spreckelmeyer, Sarah, Estrada-Ortiz, Natalia, Prins, Gerian G. H, van der Zee, Margot, Gammelgaard, Bente, Stürup, Stefan, de Graaf, Inge A. M, Groothuis, Geny M. M, Casini, Angela

Volltext

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies von de Graaf, Inge A M, Olinga, Peter, de Jager, Marina H, Merema, Marjolijn T, de Kanter, Ruben, van de Kerkhof, Esther G, Groothuis, Geny M M

Volltext

On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices von van Midwoud, Paul M, Janssen, Joost, Merema, Marjolijn T, de Graaf, Inge A. M, Groothuis, Geny M. M, Verpoorte, Elisabeth

Volltext

Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver von Daga, Martina, de Graaf, Inge A.M., Argenziano, Monica, Barranco, Ana Sofia Martinez, Loeck, Maximillian, Al-Adwi, Yehya, Cucci, Marie Angele, Caldera, Fabrizio, Trotta, Francesco, Barrera, Giuseppina, Casini, Angela, Cavalli, Roberta, Pizzimenti, Stefania

Volltext

Improved Synthesis of N‑Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity von Daum, Steffen, Chekhun, Vasiliy F, Todor, Igor N, Lukianova, Natalia Yu, Shvets, Yulia V, Sellner, Leopold, Putzker, Kerstin, Lewis, Joe, Zenz, Thorsten, de Graaf, Inge A. M, Groothuis, Geny M. M, Casini, Angela, Zozulia, Oleksii, Hampel, Frank, Mokhir, Andriy

Volltext

Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices von Martinec, Ondrej, Biel, Carin, de Graaf, Inge A. M., Huliciak, Martin, de Jong, Koert P., Staud, Frantisek, Cecka, Filip, Olinga, Peter, Vokral, Ivan, Cerveny, Lukas

Volltext

Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring von Lkhagvadorj, Khosbayar, Meyer, Karolin F., Verweij, Laura P., Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W., de Graaf, Inge A. M., Plösch, Torsten, Hylkema, Machteld N.

Volltext

Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation von Lkhagvadorj, Khosbayar, Zeng, Zhijun, Meyer, Karolin F., Verweij, Laura P., Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W., de Graaf, Inge A. M., Plosch, Torsten, Hylkema, Machteld N.

Volltext

An integrative view of cisplatin-induced renal and cardiac toxicities: molecular mechanisms, current treatment challenges and potential protective measures von Dugbartey, George J, Peppone, Luke J, Graaf, Inge A.M.de

Volltext

Rat precision-cut liver slices predict drug-induced cholestatic injury von Starokozhko, Viktoriia, Greupink, Rick, van de Broek, Petra, Soliman, Nashwa, Ghimire, Samiksha, de Graaf, Inge A. M., Groothuis, Geny M. M.

Volltext

Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study von Bigaeva, Emilia, Bomers, Jordy J.M., Biel, Carin, Mutsaers, Henricus A.M., de Graaf, Inge A.M., Boersema, Miriam, Olinga, Peter

Volltext

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo von Li, Ming, de Graaf, Inge A.M., van de Steeg, Evita, de Jager, Marina H., Groothuis, Geny M.M.

Volltext

Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites von Niu, Xiaoyu, de Graaf, Inge A. M., Langelaar-Makkinje, Miriam, Horvatovich, Peter, Groothuis, Geny M. M.

Volltext

Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells von Ambrosio, Leanne, Argenziano, Monica, Cucci, Marie Angele, Grattarola, Margherita, de Graaf, Inge A. M., Dianzani, Chiara, Barrera, Giuseppina, Sanchez Nieves, Javier, Gomez, Rafael, Cavalli, Roberta, Pizzimenti, Stefania

Volltext

Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury von van Furth, L. Annick, Leuvenink, Henri G. D., Seras, Lorina, de Graaf, Inge A. M., Olinga, Peter, van Leeuwen, L. Leonie

Volltext

Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats von Niu, Xiaoyu, de Graaf, Inge A.M., van der Bij, Hendrik A., Groothuis, Geny M.M.

Volltext

Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands von Estrada-Ortiz, Natalia, Lopez-Gonzales, Elena, Woods, Ben, Stürup, Stefan, de Graaf, Inge A M, Groothuis, Geny M M, Casini, Angela

Volltext