KLIFS: an overhaul after the first 5 years of supporting kinase research von Kanev, Georgi K, de Graaf, Chris, Westerman, Bart A, de Esch, Iwan J P, Kooistra, Albert J

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Fragment-to-Lead Medicinal Chemistry Publications in 2020 von de Esch, Iwan J. P, Erlanson, Daniel A, Jahnke, Wolfgang, Johnson, Christopher N, Walsh, Louise

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Fragment-to-Lead Medicinal Chemistry Publications in 2018 von Erlanson, Daniel A, de Esch, Iwan J. P, Jahnke, Wolfgang, Johnson, Christopher N, Mortenson, Paul N

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Structural Analysis of Chemokine Receptor–Ligand Interactions von Arimont, Marta, Sun, Shan-Liang, Leurs, Rob, Smit, Martine, de Esch, Iwan J. P, de Graaf, Chris

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The Landscape of Atypical and Eukaryotic Protein Kinases von Kanev, Georgi K., de Graaf, Chris, de Esch, Iwan J.P., Leurs, Rob, Würdinger, Thomas, Westerman, Bart A., Kooistra, Albert J.

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KLIFS: a structural kinase-ligand interaction database von Kooistra, Albert J, Kanev, Georgi K, van Linden, Oscar P J, Leurs, Rob, de Esch, Iwan J P, de Graaf, Chris

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Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries von Klein, Hanna F., Hamilton, David J., de Esch, Iwan J.P., Wijtmans, Maikel, O'Brien, Peter

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KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space von van Linden, Oscar P. J., Kooistra, Albert J., Leurs, Rob, de Esch, Iwan J. P., de Graaf, Chris

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Fragment-to-Lead Medicinal Chemistry Publications in 2019 von Jahnke, Wolfgang, Erlanson, Daniel A, de Esch, Iwan J. P, Johnson, Christopher N, Mortenson, Paul N, Ochi, Yuji, Urushima, Tatsuya

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Fragment-to-Lead Medicinal Chemistry Publications in 2021 von Walsh, Louise, Erlanson, Daniel A., de Esch, Iwan J. P., Jahnke, Wolfgang, Woodhead, Andrew, Wren, Ella

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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines von Spurny, Radovan, Ramerstorfer, Joachim, Price, Kerry, Brams, Marijke, Ernst, Margot, Nury, Hugues, Verheij, Mark, Legrand, Pierre, Bertrand, Daniel, Bertrand, Sonia, Dougherty, Dennis A, de Esch, Iwan J. P, Corringer, Pierre-Jean, Sieghart, Werner, Lummis, Sarah C. R, Ulens, Chris

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Aminergic GPCR–Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data von Vass, Márton, Podlewska, Sabina, de Esch, Iwan J. P, Bojarski, Andrzej J, Leurs, Rob, Kooistra, Albert J, de Graaf, Chris

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Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks von Kanev, Georgi K, Zhang, Yaran, Kooistra, Albert J, Bender, Andreas, Leurs, Rob, Bailey, David, Würdinger, Thomas, de Graaf, Chris, de Esch, Iwan J. P, Westerman, Bart A

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Photoswitching the Efficacy of a Small‐Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism von Gómez‐Santacana, Xavier, de Munnik, Sabrina M., Vijayachandran, Prashanna, Da Costa Pereira, Daniel, Bebelman, Jan Paul M., de Esch, Iwan J. P., Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob

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PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design von Jansen, Chimed, Kooistra, Albert J, Kanev, Georgi K, Leurs, Rob, de Esch, Iwan J. P, de Graaf, Chris

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A Photoswitchable Agonist for the Histamine H3 Receptor, a Prototypic Family A G‐Protein‐Coupled Receptor von Hauwert, Niels J., Mocking, Tamara A. M., Da Costa Pereira, Daniel, Lion, Ken, Huppelschoten, Yara, Vischer, Henry F., De Esch, Iwan J. P., Wijtmans, Maikel, Leurs, Rob

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Fragment-to-Lead Medicinal Chemistry Publications in 2017 von Mortenson, Paul N, Erlanson, Daniel A, de Esch, Iwan J P, Jahnke, Wolfgang, Johnson, Christopher N

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Fragment-to-Lead Medicinal Chemistry Publications in 2022 von Woodhead, Andrew J., Erlanson, Daniel A., de Esch, Iwan J. P., Holvey, Rhian S., Jahnke, Wolfgang, Pathuri, Puja

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The histamine H3 receptor: from gene cloning to H3 receptor drugs von Leurs, Rob, Bakker, Remko A, Timmerman, Henk, de Esch, Iwan J P

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Lead Optimization of the 5‑Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy von Zheng, Yang, van den Kerkhof, Magali, Ibrahim, Mohamed, De Esch, Iwan J. P., Maes, Louis, Sterk, Geert Jan, Caljon, Guy, Leurs, Rob

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