Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors von Besse, Andrej, Besse, Lenka, Kraus, Marianne, Mendez-Lopez, Max, Bader, Jürgen, Xin, Bo-Tao, de Bruin, Gerjan, Maurits, Elmer, Overkleeft, Herman S., Driessen, Christoph

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A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities von de Bruin, Gerjan, Xin, Bo Tao, Kraus, Marianne, van der Stelt, Mario, van der Marel, Gijsbert A., Kisselev, Alexei F., Driessen, Christoph, Florea, Bogdan I., Overkleeft, Herman S.

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Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation von Weyburne, Emily S., Wilkins, Owen M., Sha, Zhe, Williams, David A., Pletnev, Alexandre A., de Bruin, Gerjan, Overkleeft, Hermann S., Goldberg, Alfred L., Cole, Michael D., Kisselev, Alexei F.

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Proteasome Subunit Selective Activity-Based Probes Report on Proteasome Core Particle Composition in a Native Polyacrylamide Gel Electrophoresis Fluorescence-Resonance Energy Trans... von de Bruin, Gerjan, Xin, Bo-Tao, Florea, Bogdan I, Overkleeft, Herman S

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The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells von Kraus, Marianne, Bader, Juergen, Geurink, Paul P, Weyburne, Emily S, Mirabella, Anne C, Silzle, Tobias, Shabaneh, Tamer B, van der Linden, Wouter A, de Bruin, Gerjan, Haile, Sarah R, van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F, Overkleeft, Herman, Driessen, Christoph

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Two‐Step Bioorthogonal Activity‐Based Protein Profiling of Individual Human Proteasome Catalytic Sites von Xin, Bo‐Tao, Espinal, Christofer, Bruin, Gerjan, Filippov, Dmitri V., Marel, Gijsbert A., Florea, Bogdan I., Overkleeft, Herman S.

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Potency and Selectivity of BTK Inhibitors in Clinical Development for B-Cell Malignancies von Kaptein, Allard, de Bruin, Gerjan, Emmelot-van Hoek, Maaike, van de Kar, Bas, de Jong, Anouk, Gulrajani, Michael, Demont, Dennis, Covey, Todd, Mittag, Diana, Barf, Tjeerd

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A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities von de Bruin, Gerjan, Xin, Bo Tao, Kraus, Marianne, van der Stelt, Mario, van der Marel, Gijsbert A., Kisselev, Alexei F., Driessen, Christoph, Florea, Bogdan I., Overkleeft, Herman S.

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Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome von Basler, Michael, Maurits, Elmer, Bruin, Gerjan, Koerner, Julia, Overkleeft, Herman S, Groettrup, Marcus

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A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i von Huber, Eva M, Heinemeyer, Wolfgang, de Bruin, Gerjan, Overkleeft, Herman S, Groll, Michael

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A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit [beta]5i von Huber, Eva M, Heinemeyer, Wolfgang, Bruin, Gerjan, Overkleeft, Herman S, Groll, Michael

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Identification and Characterization of ACP-5862, the Major Circulating Active Metabolite of Acalabrutinib: Both Are Potent and Selective Covalent Bruton Tyrosine Kinase Inhibitors von Podoll, Terry, Pearson, Paul G., Kaptein, Allard, Evarts, Jerry, de Bruin, Gerjan, Emmelot-van Hoek, Maaike, de Jong, Anouk, van Lith, Bart, Sun, Hao, Byard, Stephen, Fretland, Adrian, Hoogenboom, Niels, Barf, Tjeerd, Slatter, J. Greg

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Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors von Huber, Eva M, de Bruin, Gerjan, Heinemeyer, Wolfgang, Paniagua Soriano, Guillem, Overkleeft, Herman S, Groll, Michael

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Structure-Based Design of β1i or β5i Specific Inhibitors of Human Immunoproteasomes von de Bruin, Gerjan, Huber, Eva M, Xin, Bo-Tao, van Rooden, Eva J, Al-Ayed, Karol, Kim, Kyung-Bo, Kisselev, Alexei F, Driessen, Christoph, van der Stelt, Mario, van der Marel, Gijsbert A, Groll, Michael, Overkleeft, Herman S

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Defining the Most Effective Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors von Besse, Andrej, Besse, Lenka, Kraus, Marianne, Bader, Juergen, de Bruin, Gerjan, Overkleeft, Herman S, Driessen, Christoph

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Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits von Xin, Bo-Tao, Huber, Eva M, de Bruin, Gerjan, Heinemeyer, Wolfgang, Maurits, Elmer, Espinal, Christofer, Du, Yimeng, Janssens, Marissa, Weyburne, Emily S, Kisselev, Alexei F, Florea, Bogdan I, Driessen, Christoph, van der Marel, Gijsbert A, Groll, Michael, Overkleeft, Herman S

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Discovery of quinoline-based irreversible BTK inhibitors von de Bruin, Gerjan, Demont, Dennis, de Zwart, Edwin, Verkaik, Saskia, Hoogenboom, Niels, van de Kar, Bas, van Lith, Bart, Emmelot- van Hoek, Maaike, Gulrajani, Michael, Covey, Todd, Kaptein, Allard, Barf, Tjeerd

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Proteasome Inhibitors with Photocontrolled Activity von Hansen, Mickel J., Velema, Willem A., de Bruin, Gerjan, Overkleeft, Herman S., Szymanski, Wiktor, Feringa, Ben L.

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Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification von Widjaja, Christella E, Olvera, Jocelyn G, Metz, Patrick J, Phan, Anthony T, Savas, Jeffrey N, de Bruin, Gerjan, Leestemaker, Yves, Berkers, Celia R, de Jong, Annemieke, Florea, Bogdan I, Fisch, Kathleen, Lopez, Justine, Kim, Stephanie H, Garcia, Daniel A, Searles, Stephen, Bui, Jack D, Chang, Aaron N, Yates, 3rd, John R, Goldrath, Ananda W, Overkleeft, Hermen S, Ovaa, Huib, Chang, John T

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Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites von Geurink, Paul P, van der Linden, Wouter A, Mirabella, Anne C, Gallastegui, Nerea, de Bruin, Gerjan, Blom, Annet E. M, Voges, Mathias J, Mock, Elliot D, Florea, Bogdan I, van der Marel, Gijs A, Driessen, Christoph, van der Stelt, Mario, Groll, Michael, Overkleeft, Herman S, Kisselev, Alexei F

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