Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects von Goyal, Navin, Skrdla, Pete, Schroyer, Rosemary, Kumar, Subramanya, Fernando, Disala, Oughton, Anna, Norton, Nicola, Sprecher, Dennis L., Cheriyan, Joseph

Volltext

Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers von Yang, Lucy, MBChB, Cheriyan, Joseph, MBChB, Gutterman, David D., MD, Mayer, Ruth J., PhD, Ament, Zsuzsanna, PhD, Griffin, Jules L., PhD, Lazaar, Aili L., MD, Newby, David E., PhD, Tal-Singer, Ruth, PhD, Wilkinson, Ian B., DM

Volltext

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist von Brame, Aimee L, Maguire, Janet J, Yang, Peiran, Dyson, Alex, Torella, Rubben, Cheriyan, Joseph, Singer, Mervyn, Glen, Robert C, Wilkinson, Ian B, Davenport, Anthony P

Volltext

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor von Lazaar, Aili L., Yang, Lucy, Boardley, Rebecca L., Goyal, Navin S., Robertson, Jonathan, Baldwin, Sandra J., Newby, David E., Wilkinson, Ian B., Tal‐Singer, Ruth, Mayer, Ruth J., Cheriyan, Joseph

Volltext

Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial von Gajendragadkar, Parag R, Hubsch, Annette, Mäki-Petäjä, Kaisa M, Serg, Martin, Wilkinson, Ian B, Cheriyan, Joseph

Volltext

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells von Inaba, Akimichi, Tuong, Zewen Kelvin, Zhao, Tian X., Stewart, Andrew P., Mathews, Rebeccah, Truman, Lucy, Sriranjan, Rouchelle, Kennet, Jane, Saeb-Parsy, Kourosh, Wicker, Linda, Waldron-Lynch, Frank, Cheriyan, Joseph, Todd, John A., Mallat, Ziad, Clatworthy, Menna R.

Volltext

The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness von Mäki-Petäjä, Kaisa M, Barrett, Sharon M.L, Evans, Sarah V, Cheriyan, Joseph, McEniery, Carmel M, Wilkinson, Ian B

Volltext

Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease von Fermont, Jilles M, Mohan, Divya, Fisk, Marie, Bolton, Charlotte E, Macnee, William, Cockcroft, John R, McEniery, Carmel, Fuld, Jonathan, Cheriyan, Joseph, Tal-Singer, Ruth, Müllerova, Hana, Wood, Angela M, Wilkinson, Ian B, Polkey, Michael I

Volltext

Association for Human Pharmacology in the Pharmaceutical Industry conference 2022: impending change, innovations and future challenges von Mundy, Charles, Bush, James, Cheriyan, Joseph, Lorch, Ulrike, Stringer, Steffan, Taubel, Jörg, Wydenbach, Kirsty, Hardman, Timothy C.

Volltext

Quantification of Lung PET Images: Challenges and Opportunities von Chen, Delphine L, Cheriyan, Joseph, Chilvers, Edwin R, Choudhury, Gourab, Coello, Christopher, Connell, Martin, Fisk, Marie, Groves, Ashley M, Gunn, Roger N, Holman, Beverley F, Hutton, Brian F, Lee, Sarah, MacNee, William, Mohan, Divya, Parr, David, Subramanian, Deepak, Tal-Singer, Ruth, Thielemans, Kris, van Beek, Edwin J R, Vass, Laurence, Wellen, Jeremy W, Wilkinson, Ian, Wilson, Frederick J

Volltext

Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients - mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 - Repurposed Drugs (TACTIC-R): A structu... von Kulkarni, Spoorthy, Fisk, Marie, Kostapanos, Michalis, Banham-Hall, Edward, Bond, Simon, Hernan-Sancho, Elena, Norton, Sam, Cheriyan, Joseph, Cope, Andrew, Galloway, James, Hall, Frances, Jayne, David, Wilkinson, Ian B

Volltext

Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study von Fermont, Jilles M, Bolton, Charlotte E, Fisk, Marie, Mohan, Divya, Macnee, William, Cockcroft, John R, McEniery, Carmel, Fuld, Jonathan, Cheriyan, Joseph, Tal-Singer, Ruth, Wilkinson, Ian B, Wood, Angela M, Polkey, Michael I, Müllerova, Hana

Volltext

Low-dose interleukin 2 for the reduction of vascular inflammation in acute coronary syndromes (IVORY): protocol and study rationale for a randomised, double-blind, placebo-controll... von Sriranjan, Rouchelle, Zhao, Tian Xiao, Tarkin, Jason, Hubsch, Annette, Helmy, Joanna, Vamvaka, Evangelia, Jalaludeen, Navazh, Bond, Simon, Hoole, Stephen P, Knott, Philip, Buckenham, Samantha, Warnes, Victoria, Bird, Nick, Cheow, Heok, Templin, Heike, Cacciottolo, Paul, Rudd, James H F, Mallat, Ziad, Cheriyan, Joseph

Volltext

Approximating Minimum-Cost $k$-Node Connected Subgraphs via Independence-Free Graphs von Cheriyan, Joseph, Végh, László A.

Volltext

The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised d... von Fisk, Marie, Cheriyan, Joseph, Mohan, Divya, Forman, Julia, Mäki-Petäjä, Kaisa M, McEniery, Carmel M, Fuld, Jonathan, Rudd, James H F, Hopkinson, Nicholas S, Lomas, David A, Cockcroft, John R, Tal-Singer, Ruth, Polkey, Michael I, Wilkinson, Ian B

Volltext

muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E): A structured summary of a study protocol for a randomized contr... von Lu, Ing Ni, Kulkarni, Spoorthy, Fisk, Marie, Kostapanos, Michalis, Banham-Hall, Edward, Kadyan, Sonakshi, Bond, Simon, Norton, Sam, Cope, Andrew, Galloway, James, Hall, Frances, Jayne, David, Wilkinson, Ian B, Cheriyan, Joseph

Volltext

Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an... von Wechalekar, Ashutosh, Antoni, Gunnar, Al Azzam, Wasfi, Bergström, Mats, Biswas, Swethajit, Chen, Chao, Cheriyan, Joseph, Cleveland, Matthew, Cookson, Louise, Galette, Paul, Janiczek, Robert L, Kwong, Raymond Y, Lukas, Mary Ann, Millns, Helen, Richards, Duncan, Schneider, Ian, Solomon, Scott D, Sörensen, Jens, Storey, James, Thompson, Douglas, van Dongen, Guus, Vugts, Danielle J, Wall, Anders, Wikström, Gerhard, Falk, Rodney H

Volltext

Effects of p38 Mitogen-Activated Protein Kinase Inhibition on Vascular and Systemic Inflammation in Patients With Atherosclerosis von Elkhawad, Maysoon, MBBChir, MA, Rudd, James H.F., MBChB, PhD, Sarov-Blat, Lea, PhD, Cai, Gengqian, PhD, Wells, Richard, BA, Davies, L. Ceri, MD, MBBS, Collier, David J., PhD, MBBS, Marber, Michael S., MBBS, PhD, Choudhury, Robin P., BMBCh, MA, DM, Fayad, Zahi A., PhD, Tawakol, Ahmed, MD, Gleeson, Fergus V., MBBS, Lepore, John J., MD, Davis, Bill, PhD, Willette, Robert N., PhD, Wilkinson, Ian B., BMBCh, DM, Sprecher, Dennis L., MD, Cheriyan, Joseph, MBChB

Volltext

Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease von Fisk, Marie, Cheriyan, Joseph, Mohan, Divya, McEniery, Carmel M, Forman, Julia, Cockcroft, John R, Rudd, James H F, Tal-Singer, Ruth, Hopkinson, Nicholas S, Polkey, Michael I, Wilkinson, Ian B

Volltext

Approximating (Unweighted) Tree Augmentation via Lift-and-Project, Part II von Cheriyan, Joseph, Gao, Zhihan

Volltext