Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability von Zwicker, Jeffery D., Diaz, Nicolas A., Guerra, Alfredo J., Kirchhoff, Paul D., Wen, Bo, Sun, Duxin, Carruthers, Vern B., Larsen, Scott D.

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Inhibition of the Vesicular Glutamate Transporter (VGLUT) with Congo Red Analogs: New Binding Insights von Hitt, David M., Zwicker, Jeffery D., Chao, Chih-Kai, Patel, Sarjubhai A., Gerdes, John M., Bridges, Richard J., Thompson, Charles M.

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Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS von Zwicker, Jeffery D, Smith, David, Guerra, Alfredo J, Hitchens, Jacob R, Haug, Nicole, Vander Roest, Steve, Lee, Pil, Wen, Bo, Sun, Duxin, Wang, Lu, Keep, Richard F, Xiang, Jianming, Carruthers, Vern B, Larsen, Scott D

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Abstract 1613: Dimerization-induced activation of the integrated stress response kinase PERK by an investigational small molecule modulator, DP-9024 von Al-Ani, Gada, Rudeen, Aaron J., Groer, Qi, Elliott, Kristin M., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javid, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Abstract 4938: DP-9024, an investigational small molecule modulator of the integrated stress response kinase GCN2, synergizes with asparaginase therapy in leukemic tumors von Al-Ani, Gada, Elliott, Kristin M., Groer, Qi, Rudeen, Aaron J., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Abstract 1640: DP-9024, an investigational small molecule modulator of the Integrated Stress Response kinase PERK, causes B-cell cancer growth inhibition as single agent and in com... von Al-Ani, Gada, Groer, Qi, Rudeen, Aaron J., Elliott, Kristin M., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Abstract 1639: DP-9149, an investigational small molecule modulator of the Integrated Stress Response kinase GCN2, pre-clinically causes solid tumor growth inhibition as a single a... von Al-Ani, Gada, Groer, Qi, Elliott, Kristin M., Rudeen, Aaron J., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javid, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Abstract 4045: DCC-3084, a RAF dimer inhibitor, broadly inhibits BRAF class I, II, III, BRAF fusions, and RAS-driven solid tumors leading to tumor regression in preclinical models von Bulfer, Stacie L., Bourdonnec, Bertrand Le, Zwicker, Jeffery D., Ahn, Yu Mi, Al-Ani, Gada, Al-Hashimi, Hikmat, Crawley, Chase, Elliott, Kristin M., Faisal, Saqib, Harned, Andrew M., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Kennedy, Michael, Large, Joshua W., Leary, Cynthia B., Lu, Wei-Ping, Luther, Kylie, Petty, Max D., Picard, Hunter R., Proto, Justin T., Romero, Yeni K., Stanley, Forrest A., Stoltz, Kristen L., Tanner, Daniel C., Telikepalli, Hanumaiah, Timson, Mary J., Vogeti, Lakshminarayana, Vogeti, Subha, Yang, Sihyung, Zhong, Lexy H., Smith, Bryan D., Flynn, Daniel L.

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