The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity von Meyer, Aaron S., Zweemer, Annelien J.M., Lauffenburger, Douglas A.

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Bias in chemokine receptor signalling von Zweemer, Annelien J.M, Toraskar, Jimita, Heitman, Laura H, IJzerman, Adriaan P

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Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies von FARATIAN, Dana, ZWEEMER, Annelien J. M, HARRISON, David J, LANGDON, Simon P, NAGUMO, Yoko, SIMS, Andrew H, MUIR, Morwenna, DODDS, Michael, MULLEN, Peter, UM, Inhwa, KAY, Charlene, HASMANN, Max

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GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment von Coban, Bircan, Wang, Zi, Liao, Chen-yi, Beslmüller, Klara, Timmermans, Mieke A.M., Martens, John W.M., Hundscheid, Jasmijn H.M., Slutter, Bram, Zweemer, Annelien J.M., Neubert, Elsa, Danen, Erik H.J.

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When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists von Vilums, Maris, Zweemer, Annelien J.M., Barmare, Farhana, van der Gracht, Anouk M.F., Bleeker, Dave C.T., Yu, Zhiyi, de Vries, Henk, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H., IJzerman, Adriaan P.

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Metastasis: crosstalk between tissue mechanics and tumour cell plasticity von Coban, Bircan, Bergonzini, Cecilia, Zweemer, Annelien J. M., Danen, Erik H. J.

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Targeting Integrins for Cancer Therapy - Disappointments and Opportunities von Bergonzini, Cecilia, Kroese, Kim, Zweemer, Annelien J M, Danen, Erik H J

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ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells von Bergonzini, Cecilia, Gregori, Alessandro, Hagens, Tessa M S, van der Noord, Vera E, van de Water, Bob, Zweemer, Annelien J M, Coban, Bircan, Capula, Mjriam, Mantini, Giulia, Botto, Asia, Finamore, Francesco, Garajova, Ingrid, McDonnell, Liam A, Schmidt, Thomas, Giovannetti, Elisa, Danen, Erik H J

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Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2 von Ortiz Zacarías, Natalia V, van Veldhoven, Jacobus P. D, Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C, Zweemer, Annelien J. M, Kreekel, Roy M, Oenema, Kenny, Lenselink, Eelke B, Heitman, Laura H, IJzerman, Adriaan P

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CC chemokine receptor 2 is allosterically modulated by sodium ions and amiloride derivatives through a distinct sodium ion binding site von den Hollander, Lisa S., Zweemer, Annelien J.M., Béquignon, Olivier J.M., Hammerl, Dora M., Bleijs, Bente T.M., Veenhuizen, Margo, Lantsheer, Wernard J.F., Chau, Bobby, van Westen, Gerard J.P., IJzerman, Adriaan P., Heitman, Laura H.

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Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells von Zweemer, Annelien J M, French, Cory B, Mesfin, Joshua, Gordonov, Simon, Meyer, Aaron S, Lauffenburger, Douglas A

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Structure–Kinetic RelationshipsAn Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists von Vilums, Maris, Zweemer, Annelien J. M, Yu, Zhiyi, de Vries, Henk, Hillger, Julia M, Wapenaar, Hannah, Bollen, Ilse A. E, Barmare, Farhana, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H, IJzerman, Adriaan P

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Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2 von Zweemer, Annelien J M, Nederpelt, Indira, Vrieling, Hilde, Hafith, Sarah, Doornbos, Maarten L J, de Vries, Henk, Abt, Jeffrey, Gross, Raymond, Stamos, Dean, Saunders, John, Smit, Martine J, Ijzerman, Adriaan P, Heitman, Laura H

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Discovery and Mapping of an Intracellular Antagonist Binding Site at the Chemokine Receptor CCR2 von Zweemer, Annelien J.M., Bunnik, Julia, Veenhuizen, Margo, Miraglia, Fabiana, Lenselink, Eelke B., Vilums, Maris, de Vries, Henk, Gibert, Arthur, Thiele, Stefanie, Rosenkilde, Mette M., IJzerman, Adriaan P., Heitman, Laura H.

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Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer von Sims, A H, Zweemer, A JM, Nagumo, Y, Faratian, D, Muir, M, Dodds, M, Um, I, Kay, C, Hasmann, M, Harrison, D J, Langdon, S P

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Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors von Wagner, Stefan, Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna

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Design and synthesis of novel small molecule CCR2 antagonists: Evaluation of 4-aminopiperidine derivatives von Vilums, M., Zweemer, A.J.M., Dekkers, S., Askar, Y., de Vries, H., Saunders, J., Stamos, D., Brussee, J., Heitman, L.H., IJzerman, A.P.

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Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2) von Strunz, Ann Kathrin, Zweemer, Annelien J.M., Weiss, Christina, Schepmann, Dirk, Junker, Anna, Heitman, Laura H., Koch, Michael, Wünsch, Bernhard

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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists von Junker, Anna, Kokornaczyk, Artur K, Zweemer, Annelien J M, Frehland, Bastian, Schepmann, Dirk, Yamaguchi, Junichiro, Itami, Kenichiro, Faust, Andreas, Hermann, Sven, Wagner, Stefan, Schäfers, Michael, Koch, Michael, Weiss, Christina, Heitman, Laura H, Kopka, Klaus, Wünsch, Bernhard

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Targeting integrins for cancer therapy - disappointments and opportunities von Bergonzini, C., Kroese, K., Zweemer, J.M., Danen, E.H.J.

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