ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells von Bergonzini, Cecilia, Gregori, Alessandro, Hagens, Tessa M S, van der Noord, Vera E, van de Water, Bob, Zweemer, Annelien J M, Coban, Bircan, Capula, Mjriam, Mantini, Giulia, Botto, Asia, Finamore, Francesco, Garajova, Ingrid, McDonnell, Liam A, Schmidt, Thomas, Giovannetti, Elisa, Danen, Erik H J

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Metastasis: crosstalk between tissue mechanics and tumour cell plasticity von Coban, Bircan, Bergonzini, Cecilia, Zweemer, Annelien J. M., Danen, Erik H. J.

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Targeting Integrins for Cancer Therapy - Disappointments and Opportunities von Bergonzini, Cecilia, Kroese, Kim, Zweemer, Annelien J M, Danen, Erik H J

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Bias in chemokine receptor signalling von Zweemer, Annelien J.M, Toraskar, Jimita, Heitman, Laura H, IJzerman, Adriaan P

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Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2 von Ortiz Zacarías, Natalia V, van Veldhoven, Jacobus P. D, Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C, Zweemer, Annelien J. M, Kreekel, Roy M, Oenema, Kenny, Lenselink, Eelke B, Heitman, Laura H, IJzerman, Adriaan P

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False Positives in a Reporter Gene Assay: Identification and Synthesis of Substituted N-Pyridin-2-ylbenzamides as Competitive Inhibitors of Firefly Luciferase von Heitman, Laura H, van Veldhoven, Jacobus P. D, Zweemer, Annelien M, Ye, Kai, Brussee, Johannes, IJzerman, Adriaan P

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Structure–Kinetic RelationshipsAn Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists von Vilums, Maris, Zweemer, Annelien J. M, Yu, Zhiyi, de Vries, Henk, Hillger, Julia M, Wapenaar, Hannah, Bollen, Ilse A. E, Barmare, Farhana, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H, IJzerman, Adriaan P

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Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells von Zweemer, Annelien J M, French, Cory B, Mesfin, Joshua, Gordonov, Simon, Meyer, Aaron S, Lauffenburger, Douglas A

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Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2 von Zweemer, Annelien J M, Nederpelt, Indira, Vrieling, Hilde, Hafith, Sarah, Doornbos, Maarten L J, de Vries, Henk, Abt, Jeffrey, Gross, Raymond, Stamos, Dean, Saunders, John, Smit, Martine J, Ijzerman, Adriaan P, Heitman, Laura H

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Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies von FARATIAN, Dana, ZWEEMER, Annelien J. M, HARRISON, David J, LANGDON, Simon P, NAGUMO, Yoko, SIMS, Andrew H, MUIR, Morwenna, DODDS, Michael, MULLEN, Peter, UM, Inhwa, KAY, Charlene, HASMANN, Max

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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists von Junker, Anna, Kokornaczyk, Artur K, Zweemer, Annelien J M, Frehland, Bastian, Schepmann, Dirk, Yamaguchi, Junichiro, Itami, Kenichiro, Faust, Andreas, Hermann, Sven, Wagner, Stefan, Schäfers, Michael, Koch, Michael, Weiss, Christina, Heitman, Laura H, Kopka, Klaus, Wünsch, Bernhard

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CC chemokine receptor 2 is allosterically modulated by sodium ions and amiloride derivatives through a distinct sodium ion binding site von den Hollander, Lisa S., Zweemer, Annelien J.M., Béquignon, Olivier J.M., Hammerl, Dora M., Bleijs, Bente T.M., Veenhuizen, Margo, Lantsheer, Wernard J.F., Chau, Bobby, van Westen, Gerard J.P., IJzerman, Adriaan P., Heitman, Laura H.

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Normalization Strategies for Lipidome Data in Cell Line Panels von Leegwater, Hanneke, Zhang, Zhengzheng, Zhang, Xiaobing, Hankemeier, Thomas, Harms, Amy C., Zweemer, Annelien J. M., Le Dévédec, Sylvia E., Kindt, Alida

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Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor von Vilums, Maris, Zweemer, Annelien J. M., Dilanchian, Arian, van Veldhoven, Jacobus P. D., de Vries, Henk, Brussee, Johannes, Saunders, John, Stamos, Dean, Heitman, Laura H., IJzerman, Adriaan P.

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A Series of 2,4-Disubstituted Quinolines as a New Class of Allosteric Enhancers of the Adenosine A3 Receptor von Heitman, Laura H, Göblyös, Anikó, Zweemer, Annelien M, Bakker, Renée, Mulder-Krieger, Thea, van Veldhoven, Jacobus P. D, de Vries, Henk, Brussee, Johannes, IJzerman, Adriaan P

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Discovery and Mapping of an Intracellular Antagonist Binding Site at the Chemokine Receptor CCR2 von Zweemer, Annelien J.M., Bunnik, Julia, Veenhuizen, Margo, Miraglia, Fabiana, Lenselink, Eelke B., Vilums, Maris, de Vries, Henk, Gibert, Arthur, Thiele, Stefanie, Rosenkilde, Mette M., IJzerman, Adriaan P., Heitman, Laura H.

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The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity von Meyer, Aaron S., Zweemer, Annelien J.M., Lauffenburger, Douglas A.

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Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors von Wagner, Stefan, Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna

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GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment von Coban, Bircan, Wang, Zi, Liao, Chen-yi, Beslmüller, Klara, Timmermans, Mieke A.M., Martens, John W.M., Hundscheid, Jasmijn H.M., Slutter, Bram, Zweemer, Annelien J.M., Neubert, Elsa, Danen, Erik H.J.

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When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists von Vilums, Maris, Zweemer, Annelien J.M., Barmare, Farhana, van der Gracht, Anouk M.F., Bleeker, Dave C.T., Yu, Zhiyi, de Vries, Henk, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H., IJzerman, Adriaan P.

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