ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells von Bergonzini, Cecilia, Gregori, Alessandro, Hagens, Tessa M S, van der Noord, Vera E, van de Water, Bob, Zweemer, Annelien J M, Coban, Bircan, Capula, Mjriam, Mantini, Giulia, Botto, Asia, Finamore, Francesco, Garajova, Ingrid, McDonnell, Liam A, Schmidt, Thomas, Giovannetti, Elisa, Danen, Erik H J

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Metastasis: crosstalk between tissue mechanics and tumour cell plasticity von Coban, Bircan, Bergonzini, Cecilia, Zweemer, Annelien J. M., Danen, Erik H. J.

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Targeting Integrins for Cancer Therapy - Disappointments and Opportunities von Bergonzini, Cecilia, Kroese, Kim, Zweemer, Annelien J M, Danen, Erik H J

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Normalization Strategies for Lipidome Data in Cell Line Panels von Leegwater, Hanneke, Zhang, Zhengzheng, Zhang, Xiaobing, Hankemeier, Thomas, Harms, Amy C., Zweemer, Annelien J. M., Le Dévédec, Sylvia E., Kindt, Alida

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Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2 von Ortiz Zacarías, Natalia V, van Veldhoven, Jacobus P. D, Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C, Zweemer, Annelien J. M, Kreekel, Roy M, Oenema, Kenny, Lenselink, Eelke B, Heitman, Laura H, IJzerman, Adriaan P

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Bias in chemokine receptor signalling von Zweemer, Annelien J.M, Toraskar, Jimita, Heitman, Laura H, IJzerman, Adriaan P

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Structure–Kinetic RelationshipsAn Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists von Vilums, Maris, Zweemer, Annelien J. M, Yu, Zhiyi, de Vries, Henk, Hillger, Julia M, Wapenaar, Hannah, Bollen, Ilse A. E, Barmare, Farhana, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H, IJzerman, Adriaan P

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Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells von Zweemer, Annelien J M, French, Cory B, Mesfin, Joshua, Gordonov, Simon, Meyer, Aaron S, Lauffenburger, Douglas A

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Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2 von Zweemer, Annelien J M, Nederpelt, Indira, Vrieling, Hilde, Hafith, Sarah, Doornbos, Maarten L J, de Vries, Henk, Abt, Jeffrey, Gross, Raymond, Stamos, Dean, Saunders, John, Smit, Martine J, Ijzerman, Adriaan P, Heitman, Laura H

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Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies von FARATIAN, Dana, ZWEEMER, Annelien J. M, HARRISON, David J, LANGDON, Simon P, NAGUMO, Yoko, SIMS, Andrew H, MUIR, Morwenna, DODDS, Michael, MULLEN, Peter, UM, Inhwa, KAY, Charlene, HASMANN, Max

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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists von Junker, Anna, Kokornaczyk, Artur K, Zweemer, Annelien J M, Frehland, Bastian, Schepmann, Dirk, Yamaguchi, Junichiro, Itami, Kenichiro, Faust, Andreas, Hermann, Sven, Wagner, Stefan, Schäfers, Michael, Koch, Michael, Weiss, Christina, Heitman, Laura H, Kopka, Klaus, Wünsch, Bernhard

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Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor von Vilums, Maris, Zweemer, Annelien J. M., Dilanchian, Arian, van Veldhoven, Jacobus P. D., de Vries, Henk, Brussee, Johannes, Saunders, John, Stamos, Dean, Heitman, Laura H., IJzerman, Adriaan P.

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CC chemokine receptor 2 is allosterically modulated by sodium ions and amiloride derivatives through a distinct sodium ion binding site von den Hollander, Lisa S., Zweemer, Annelien J.M., Béquignon, Olivier J.M., Hammerl, Dora M., Bleijs, Bente T.M., Veenhuizen, Margo, Lantsheer, Wernard J.F., Chau, Bobby, van Westen, Gerard J.P., IJzerman, Adriaan P., Heitman, Laura H.

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Discovery and Mapping of an Intracellular Antagonist Binding Site at the Chemokine Receptor CCR2 von Zweemer, Annelien J.M., Bunnik, Julia, Veenhuizen, Margo, Miraglia, Fabiana, Lenselink, Eelke B., Vilums, Maris, de Vries, Henk, Gibert, Arthur, Thiele, Stefanie, Rosenkilde, Mette M., IJzerman, Adriaan P., Heitman, Laura H.

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Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors von Wagner, Stefan, Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna

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The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity von Meyer, Aaron S., Zweemer, Annelien J.M., Lauffenburger, Douglas A.

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GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment von Coban, Bircan, Wang, Zi, Liao, Chen-yi, Beslmüller, Klara, Timmermans, Mieke A.M., Martens, John W.M., Hundscheid, Jasmijn H.M., Slutter, Bram, Zweemer, Annelien J.M., Neubert, Elsa, Danen, Erik H.J.

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Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2) von Strunz, Ann Kathrin, Zweemer, Annelien J.M., Weiss, Christina, Schepmann, Dirk, Junker, Anna, Heitman, Laura H., Koch, Michael, Wünsch, Bernhard

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When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists von Vilums, Maris, Zweemer, Annelien J.M., Barmare, Farhana, van der Gracht, Anouk M.F., Bleeker, Dave C.T., Yu, Zhiyi, de Vries, Henk, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H., IJzerman, Adriaan P.

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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonistsElectronic supplementary information (ESI)... von Junker, Anna, Kokornaczyk, Artur K, Zweemer, Annelien J. M, Frehland, Bastian, Schepmann, Dirk, Yamaguchi, Junichiro, Itami, Kenichiro, Faust, Andreas, Hermann, Sven, Wagner, Stefan, Schäfers, Michael, Koch, Michael, Weiss, Christina, Heitman, Laura H, Kopka, Klaus, Wünsch, Bernhard

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