Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2 von Garami, Attila, Zwartkruis, Fried J.T, Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Stocker, Hugo, Kozma, Sara C, Hafen, Ernst, Bos, Johannes L, Thomas, George

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CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation von De Rubeis, Silvia, Pasciuto, Emanuela, Li, Ka Wan, Fernández, Esperanza, Di Marino, Daniele, Buzzi, Andrea, Ostroff, Linnaea E., Klann, Eric, Zwartkruis, Fried J.T., Komiyama, Noboru H., Grant, Seth G.N., Poujol, Christel, Choquet, Daniel, Achsel, Tilmann, Posthuma, Danielle, Smit, August B., Bagni, Claudia

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Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress von Zimmer, Till S., Korotkov, Anatoly, Zwakenberg, Susan, Jansen, Floor E., Zwartkruis, Fried J. T., Rensing, Nicholas R., Wong, Michael, Mühlebner, Angelika, Vliet, Erwin A., Aronica, Eleonora, Mills, James D.

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The malate-aspartate shuttle is important for de novo serine biosynthesis von Broeks, Melissa H., Meijer, Nils W.F., Westland, Denise, Bosma, Marjolein, Gerrits, Johan, German, Hannah M., Ciapaite, Jolita, van Karnebeek, Clara D.M., Wanders, Ronald J.A., Zwartkruis, Fried J.T., Verhoeven-Duif, Nanda M., Jans, Judith J.M.

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Cell–cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors von Pannekoek, Willem-Jan, Kooistra, Matthijs R.H., Zwartkruis, Fried J.T., Bos, Johannes L.

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Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control von Pannekoek, Willem-Jan, van Dijk, Jantine J.G., Chan, On Ying A., Huveneers, Stephan, Linnemann, Jelena R., Spanjaard, Emma, Brouwer, Patricia M., van der Meer, Anne Jan, Zwartkruis, Fried J.T., Rehmann, Holger, de Rooij, Johan, Bos, Johannes L.

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Control of Epithelial Cell Migration and Invasion by the IKKβ- and CK1α-Mediated Degradation of RAPGEF2 von Magliozzi, Roberto, Low, Teck Yew, Weijts, Bart G.M.W., Cheng, Tianhong, Spanjaard, Emma, Mohammed, Shabaz, van Veen, Anouk, Ovaa, Huib, de Rooij, Johan, Zwartkruis, Fried J.T., Bos, Johannes L., de Bruin, Alain, Heck, Albert J.R., Guardavaccaro, Daniele

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The Small GTPase, Rap1, Mediates CD31-Induced Integrin Adhesion von Reedquist, Kris A., Ross, Ewan, Koop, Elianne A., Rob M. F. Wolthuis, Fried J. T. Zwartkruis, van Kooyk, Yvette, Salmon, Mike, Buckley, Christopher D., Bos, Johannes L.

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Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling von Zwartkruis, Fried J.T., Wolthuis, Rob M.F., Nabben, Nicolle M.J.M., Franke, Barbara, Bos, Johannes L.

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Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2 von Kuiperij, H.Bea, de Rooij, Johan, Rehmann, Holger, van Triest, Miranda, Wittinghofer, Alfred, Bos, Johannes L, Zwartkruis, Fried J.T

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The long-term effect of mTOR inhibition on lipid and glucose metabolism in tuberous sclerosis complex: data from the Dutch TSC registry von Mulder, Femke V.M, Peeters, Evelien F.H.I, Westerink, Jan, Zwartkruis, Fried J.T, de Ranitz-Greven, Wendela L

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mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes von Zwakenberg, Susan, Westland, Denise, van Es, Robert M., Rehmann, Holger, Anink, Jasper, Ciapaite, Jolita, Bosma, Marjolein, Stelloo, Ellen, Liv, Nalan, Sobrevals Alcaraz, Paula, Verhoeven-Duif, Nanda M., Jans, Judith J.M., Vos, Harmjan R., Aronica, Eleonora, Zwartkruis, Fried J.T.

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mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy von Schlingmann, Karl P., Jouret, Francois, Shen, Kuang, Nigam, Anukrati, Arjona, Francisco J., Dafinger, Claudia, Houillier, Pascal, Jones, Deborah P., Kleinerueschkamp, Felix, Oh, Jun, Godefroid, Nathalie, Eltan, Mehmet, Guran, Tulay, Burtey, Stephane, Parotte, Marie-Christine, Koenig, Jens, Braun, Alina, Bos, Caro, Serra, Maria Ibars, Rehmann, Holger, Zwartkruis, Fried J. T., Renkema, Kirsten Y., Klingel, Karin, Schulze-Bahr, Eric, Schermer, Bernhard, Bergmann, Carsten, Altmueller, Janine, Thiele, Holger, Beck, Bodo B., Dahan, Karin, Sabatini, David, Liebau, Max C., Vargas-Poussou, Rosa, Knoers, Nine V. A. M., Konrad, Martin, de Baaij, Jeroen H. F.

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Amino Acids Mediate mTOR/Raptor Signaling through Activation of Class 3 Phosphatidylinositol 3OH-Kinase von Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Dann, Stephen G., Kim, So Young, Gulati, Pawan, Byfield, Maya P., Backer, Jonathan M., Natt, Francois, Bos, Johannes L., Fried J. T. Zwartkruis, Thomas, George, Schlessinger, Joseph

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Evolution of the TOR Pathway von van Dam, Teunis J. P., Zwartkruis, Fried J. T., Bos, Johannes L., Snel, Berend

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Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy von Rumping, Lynne, Büttner, Benjamin, Maier, Oliver, Rehmann, Holger, Lequin, Maarten, Schlump, Jan-Ulrich, Schmitt, Bernhard, Schiebergen-Bronkhorst, Birgit, Prinsen, Hubertus C. M. T, Losa, Michele, Fingerhut, Ralph, Lemke, Johannes R, Zwartkruis, Fried J. T, Houwen, Roderick H. J, Jans, Judith J. M, Verhoeven-Duif, Nanda M, van Hasselt, Peter M, Jamra, Rami

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Maintenance of cellular vitamin B6 levels and mitochondrial oxidative function depend on pyridoxal 5′-phosphate homeostasis protein von Ciapaite, Jolita, van Roermund, Carlo W.T., Bosma, Marjolein, Gerrits, Johan, Houten, Sander M., IJlst, Lodewijk, Waterham, Hans R., van Karnebeek, Clara D.M., Wanders, Ronald J.A., Zwartkruis, Fried J.T., Jans, Judith J., Verhoeven-Duif, Nanda M.

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Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB Phosphoserines von Glykofridis, Iris E, Henneman, Alex A, Balk, Jesper A, Haas, Richard Goeij De, Westland, Denise, Piersma, Sander R, Knol, Jaco C, Pham, Thang V, Boekhout, Michiel, Zwartkruis, Fried J.T, Wolthuis, Rob M.F, Jimenez, Connie R

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Pyridox(am)ine 5′-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations von Ciapaite, Jolita, Albersen, Monique, Savelberg, Sanne M.C., Bosma, Marjolein, Tessadori, Federico, Gerrits, Johan, Lansu, Nico, Zwakenberg, Susan, Bakkers, Jeroen P.W., Zwartkruis, Fried J.T., van Haaften, Gijs, Jans, Judith J., Verhoeven-Duif, Nanda M.

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The long-term effect of mTOR inhibition on lipid and glucose metabolism in tuberous sclerosis complex: data from the Dutch TSC registry von Mulder, Femke V M, Peeters, Evelien F H I, Westerink, Jan, Zwartkruis, Fried J T, de Ranitz-Greven, Wendela L

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