Leukemia's Next Top Model? Syngeneic Models to Advance Adoptive Cellular Therapy von Zoine, Jaquelyn T, Moore, Sarah E, Velasquez, M Paulina

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Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model von Zoine, Jaquelyn T., Knight, Kristopher A., Fleischer, Lauren C., Sutton, Kathryn S., Goldsmith, Kelly C., Doering, Christopher B., Spencer, H. Trent

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Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII von Russell, Athena L., Prince, Chengyu, Lundgren, Taran S., Knight, Kristopher A., Denning, Gabriela, Alexander, Jordan S., Zoine, Jaquelyn T., Spencer, H. Trent, Chandrakasan, Shanmuganathan, Doering, Christopher B.

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Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy von Burnham, Rebecca E., Zoine, Jaquelyn T., Story, Jamie Y., Garimalla, Swetha N., Gibson, Greg, Rae, Aaron, Williams, Erich, Bixby, Lisa, Archer, David, Doering, Christopher B., Spencer, H. Trent

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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity von Funk, Christopher Ronald, Wang, Shuhua, Chen, Kevin Z., Waller, Alexandra, Sharma, Aditi, Edgar, Claudia L., Gupta, Vikas A., Chandrakasan, Shanmuganathan, Zoine, Jaquelyn T., Fedanov, Andrew, Raikar, Sunil S., Koff, Jean L., Flowers, Christopher R., Coma, Silvia, Pachter, Jonathan A., Ravindranathan, Sruthi, Spencer, H. Trent, Shanmugam, Mala, Waller, Edmund K.

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Engineering naturally occurring CD7− T cells for the immunotherapy of hematological malignancies von Freiwan, Abdullah, Zoine, Jaquelyn T., Crawford, Jeremy Chase, Vaidya, Abishek, Schattgen, Stefan A., Myers, Jacquelyn A., Patil, Sagar L., Khanlari, Mahsa, Inaba, Hiroto, Klco, Jeffery M., Mullighan, Charles G., Krenciute, Giedre, Chockley, Peter J., Naik, Swati, Langfitt, Deanna M., Mamonkin, Maksim, Obeng, Esther A., Thomas, Paul G., Gottschalk, Stephen, Velasquez, M. Paulina

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Thrombopoietin-based CAR-T cells demonstrate in vitro and in vivo cytotoxicity to MPL positive acute myelogenous leukemia and hematopoietic stem cells von Zoine, Jaquelyn T., Prince, Chengyu, Story, Jamie Y., Branella, Gianna M., Lytle, Allison M., Fedanov, Andrew, Alexander, Jordan S., Porter, Christopher C., Doering, Christopher B., Spencer, H. Trent, Chandrakasan, Shanmuganathan

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Bortezomib enhances cytotoxicity of ex vivo-expanded gamma delta T cells against acute myeloid leukemia and T-cell acute lymphoblastic leukemia von Story, Jamie Y., Zoine, Jaquelyn T., Burnham, Rebecca E., Hamilton, Jamie A.G., Spencer, H. Trent, Doering, Christopher B., Raikar, Sunil S.

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Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity von Zoine, Jaquelyn T., Immadisetty, Kalyan, Ibanez-Vega, Jorge, Moore, Sarah E., Nevitt, Chris, Thanekar, Unmesha, Tian, Liqing, Karouni, Abbas, Chockley, Peter J., Arthur, Bright, Sheppard, Heather, Klco, Jeffery M., Langfitt, Deanna M., Krenciute, Giedre, Gottschalk, Stephen, Babu, M. Madan, Velasquez, M. Paulina

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Structural Changes in Peptide-Scfv Bispecific Cars Impact T Cell Effector Function Against Acute Myeloid Leukemia von Zoine, Jaquelyn T., Moore, Sarah E., Immadisetty, Kalyan, Akel, Shams, Langfitt, Deanna M, Ibanez-Vega, Jorge, Talbot, Lindsay, DeRenzo, Chris, Krenciute, Giedre, Babu, M. Madan, Velasquez, Mireya Paulina

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Establishing Immunocompetent Leukemia Models to Investigate the Impact of CAR T Cells on the Immune Microenvironment and Bone Marrow Niche von Moore, Sarah E., Zoine, Jaquelyn T., Crawford, Jeremy Chase, Langfitt, Deanna, Barajas, Juan M., Abdelhamed, Sherif, Iacobucci, Ilaria, Haydar, Dalia, Krenciute, Giedre, Mullighan, Charles G., Klco, Jeffery M., Gottschalk, Stephen, Thomas, Paul G., Velasquez, Mireya Paulina

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Abstract B42: The properties of ex vivo expanded γδ T cells provide for the rational use of combination therapies von Zoine, Jaquelyn T., Sutton, Kathryn S., Knight, Kristopher A., Goldsmith, Kelly C., Doering, Christopher B., Spencer, H. Trent

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Safety and Anti-Leukemic Activity of CD123-CAR T Cells in Pediatric Patients with AML: Preliminary Results from a Phase 1 Trial von Naik, Swati, Madden, Renee M., Lipsitt, Amanda, Lockey, Timothy, Bran, Jennyfer, Rubnitz, Jeffrey E., Klco, Jeffery, Shulkin, Barry, Patil, Sagar L., Schell, Sarah, Park, Jeoungeun John, Riberdy, Janice, Shang, Na, Zoine, Jaquelyn T., Wallace, Jennifer, Harstead, Elaine, Willis, Catherine, Metais, Jean-Yves, Langfitt, Deanna M., Zhou, Sheng, Akel, Salem M., Meagher, Michael M., Triplett, Brandon M., Gottschalk, Stephen, Velasquez, Mireya Paulina

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Characterization of Donor Variability for gamma delta T Cell ex vivo Expansion and Development of an Allogeneic gamma delta T Cell Immunotherapy von Burnham, Rebecca E., Zoine, Jaquelyn T., Story, Jamie Y., Garimalla, Swetha N., Gibson, Greg, Rae, Aaron, Williams, Erich, Bixby, Lisa, Archer, David, Doering, Christopher B., Spencer, H. Trent

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Bortezomib enhances cytotoxicity of ex vivo expanded gamma delta (γδ) T cells against AML and T-ALL von Story, Jamie Y., Zoine, Jaquelyn T., Ryan, Becca E., Hamilton, Jamie A., Spencer, H. Trent, Doering, Christopher B., Raikar, Sunil S.

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IMMU-01. EVALUATING THE IMPACT OF CAR DESIGN ON THE TUMOR IMMUNE MICROENVIRONMENT AND ANTI-TUMOR RESPONSE IN SYNGENEIC GLIOMA MODELS von Haydar, Dalia, Crawford, Jeremy, Chou, Ching-Heng, Guy, Cliff, Yi, Zhongzhen, Zoine, Jaquelyn, Gottschalk, Stephen, Roussel, Martine, Thomas, Paul, Krenciute, Giedre

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Preliminary Results from a Phase 1 Trial Showing Safety and Anti-Leukemic Activity of CD123-CAR T Cells in Pediatric Patients with AML von Naik, Swati, Madden, Renee, Lipsitt, Amanda, Lockey, Timothy, Bran, Jennyfer, Rubnitz, Jeffrey E, Klco, Jeffery, Shulkin, Barry L., Patil, Sagar L, Schell, Sarah S, Park, Jeoung-Eun John, Riberdy, Janice, Shang, Na, Zoine, Jaquelyn, Wallace, Jennifer, Harstead, Katheryn, Willis, Catherine, Metais, Jean-Yves, Langfitt, Deanna, Zhou, Sheng, Akel, Salem, Meagher, Michael, Triplett, Brandon M., Gottschalk, Stephen, Velasquez, Paulina Paulina

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115 - Preliminary Results from a Phase 1 Trial Showing Safety and Anti-Leukemic Activity of CD123-CAR T Cells in Pediatric Patients with AML von Naik, Swati, Madden, Renee, Lipsitt, Amanda, Lockey, Timothy, Bran, Jennyfer, Rubnitz, Jeffrey E, Klco, Jeffery, Shulkin, Barry L., Patil, Sagar L, Schell, Sarah S, Park, Jeoung-Eun John, Riberdy, Janice, Shang, Na, Zoine, Jaquelyn, Wallace, Jennifer, Harstead, Katheryn, Willis, Catherine, Metais, Jean-Yves, Langfitt, Deanna, Zhou, Sheng, Akel, Salem, Meagher, Michael, Triplett, Brandon M., Gottschalk, Stephen, Velasquez, Paulina Paulina

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BISPECIFIC CHIMERIC ANTIGEN RECEPTORS TARGETING GRP78 AND CD123 OR GRP78 AND B7H3 von ZOINE, Jaquelyn, GOTTSCHALK, Stephen, VELASQUEZ, Mireya, HEBBAR, Nikhil

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BISPECIFIC CHIMERIC ANTIGEN RECEPTORS TARGETING GRP78 AND CD123 OR GRP78 AND B7H3 von ZOINE, Jaquelyn, GOTTSCHALK, Stephen, VELASQUEZ, Mireya, HEBBAR, Nikhil

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