Crystal structure of Middle East respiratory syndrome coronavirus helicase von Hao, Wei, Wojdyla, Justyna Aleksandra, Zhao, Rong, Han, Ruiyun, Das, Rajat, Zlatev, Ivan, Manoharan, Muthiah, Wang, Meitian, Cui, Sheng

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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides von Iwamoto, Naoki, Butler, David C D, Svrzikapa, Nenad, Mohapatra, Susovan, Zlatev, Ivan, Sah, Dinah W Y, Meena, Standley, Stephany M, Lu, Genliang, Apponi, Luciano H, Frank-Kamenetsky, Maria, Zhang, Jason Jingxin, Vargeese, Chandra, Verdine, Gregory L

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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity von Janas, Maja M., Schlegel, Mark K., Harbison, Carole E., Yilmaz, Vedat O., Jiang, Yongfeng, Parmar, Rubina, Zlatev, Ivan, Castoreno, Adam, Xu, Huilei, Shulga-Morskaya, Svetlana, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Keirstead, Natalie D., Maier, Martin A., Jadhav, Vasant

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Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen von Uijl, Estrellita, Mirabito Colafella, Katrina M, Sun, Yuan, Ren, Liwei, van Veghel, Richard, Garrelds, Ingrid M, de Vries, René, Poglitsch, Marko, Zlatev, Ivan, Kim, Jae B, Hoorn, Ewout J, Foster, Don, Danser, A.H Jan

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Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5 '-(R)- and 5 '-(S)-C-methyl-guanosine von Mikami, Atsushi, Erande, Namrata, Matsuda, Shigeo, Kel'in, Alexander, Woods, Lauren Blair, Chickering, Tyler, Pallan, Pradeep S., Schlegel, Mark K., Zlatev, Ivan, Egli, Martin, Manoharan, Muthiah

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Influenza A virus-generated small RNAs regulate the switch from transcription to replication von Perez, Jasmine T., Varble, Andrew, Sachidanandam, Ravi, Zlatev, Ivan, Manoharan, Muthiah, Garcia-Sastre, Adolfo, tenOever, Benjamin R., Palese, Peter

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Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA von Schlegel, Mark K, Foster, Donald J, Kel’in, Alexander V, Zlatev, Ivan, Bisbe, Anna, Jayaraman, Muthusamy, Lackey, Jeremy G, Rajeev, Kallanthottathil G, Charissé, Klaus, Harp, Joel, Pallan, Pradeep S, Maier, Martin A, Egli, Martin, Manoharan, Muthiah

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Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease von Bovée, Dominique M., Ren, Liwei, Uijl, Estrellita, Clahsen-van Groningen, Marian C., van Veghel, Richard, Garrelds, Ingrid M., Domenig, Oliver, Poglitsch, Marko, Zlatev, Ivan, Kim, Jae B., Huang, Stephen, Melton, Lauren, Lu, Xifeng, Hoorn, Ewout J., Foster, Don, Danser, A.H. Jan

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4′‑C‑Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing von Malek-Adamian, Elise, Guenther, Dale C, Matsuda, Shigeo, Martínez-Montero, Saúl, Zlatev, Ivan, Harp, Joel, Burai Patrascu, Mihai, Foster, Donald J, Fakhoury, Johans, Perkins, Lydia, Moitessier, Nicolas, Manoharan, Rajar M, Taneja, Nate, Bisbe, Anna, Charisse, Klaus, Maier, Martin, Rajeev, Kallanthottathil G, Egli, Martin, Manoharan, Muthiah, Damha, Masad J

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Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′‑(E)- and 5′‑(Z)‑Vinylphosphonate-Modified siRNA Conjugates von Parmar, Rubina Giare, Brown, Christopher R, Matsuda, Shigeo, Willoughby, Jennifer L. S, Theile, Christopher S, Charissé, Klaus, Foster, Donald J, Zlatev, Ivan, Jadhav, Vasant, Maier, Martin A, Egli, Martin, Manoharan, Muthiah, Rajeev, Kallanthottathil G

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siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′... von Akabane-Nakata, Masaaki, Erande, Namrata D, Kumar, Pawan, Degaonkar, Rohan, Gilbert, Jason A, Qin, June, Mendez, Martha, Woods, Lauren Blair, Jiang, Yongfeng, Janas, Maja M, O’Flaherty, Derek K, Zlatev, Ivan, Schlegel, Mark K, Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah

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Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity von Harp, Joel M, Guenther, Dale C, Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R, Zlatev, Ivan, Foster, Donald J, Taneja, Nate, Charisse, Klaus, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Egli, Martin

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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes von Subramanian, Megha, McIninch, James, Zlatev, Ivan, Schlegel, Mark K., Kaittanis, Charalambos, Nguyen, Tuyen, Agarwal, Saket, Racie, Timothy, Alvarado, Martha Arbaiza, Wassarman, Kelly, Collins, Thomas S., Chickering, Tyler, Brown, Christopher R., Schmidt, Karyn, Castoreno, Adam B., Shulga-Morskaya, Svetlana, Stamenova, Elena, Buckowing, Kira, Berman, Daniel, Barry, Joseph D., Bisbe, Anna, Maier, Martin A., Fitzgerald, Kevin, Jadhav, Vasant

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Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′‑C‑Methyl Pyrimidine-Modified Oligonucleotides von Kel′in, Alexander V, Zlatev, Ivan, Harp, Joel, Jayaraman, Muthusamy, Bisbe, Anna, O′Shea, Jonathan, Taneja, Nate, Manoharan, Rajar M, Khan, Saeed, Charisse, Klaus, Maier, Martin A, Egli, Martin, Rajeev, Kallanthottathil G, Manoharan, Muthiah

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A Small-RNA Enhancer of Viral Polymerase Activity von PEREZ, Jasmine T, ZLATEV, Ivan, AGGARWAL, Shilpa, SUBRAMANIAN, Sailakshmi, SACHIDANANDAM, Ravi, KIM, Baek, MANOHARAN, Muthiah, TENOEVER, Benjamin R

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Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates von Brown, Christopher R, Gupta, Swati, Qin, June, Racie, Timothy, He, Guo, Lentini, Scott, Malone, Ryan, Yu, Mikyung, Matsuda, Shigeo, Shulga-Morskaya, Svetlana, Nair, Anil V, Theile, Christopher S, Schmidt, Karyn, Shahraz, Azar, Goel, Varun, Parmar, Rubina G, Zlatev, Ivan, Schlegel, Mark K, Nair, Jayaprakash K, Jayaraman, Muthusamy, Manoharan, Muthiah, Brown, Dennis, Maier, Martin A, Jadhav, Vasant

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A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo von Lee, Justin B, Zhang, Kaixin, Tam, Yuen Yi C, Quick, Joslyn, Tam, Ying K, Lin, Paulo JC, Chen, Sam, Liu, Yan, Nair, Jayaprakash K, Zlatev, Ivan, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Rennie, Paul S, Cullis, Pieter R

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Investigating the pharmacodynamic durability o f GalNAc-siRNA conjugates von Brown, Christopher R., Gupta, Swati, Qin, June, Racie, Timothy, He, Guo, Lentini, Scott, Malone, Ryan, Yu, Mikyung, Matsuda, Shigeo, Shulga-Morskaya, Svetlana, Nair, Anil, Theile, Christopher S., Schmidt, Karyn, Shahraz, Azar, Goel, Varun, Parmar, Rubina G., Zlatev, Ivan, Schlegel, Mark K., Nair, Jayaprakash K., Jayaraman, Muthusamy, Manoharan, Muthiah, Brown, Dennis, Maier, Martin A., Jadhav, Vasant

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Aminooxy Click Chemistry as a Tool for Bis-homo and Bis-hetero Ligand Conjugation to Nucleic Acids von Datta, Dhrubajyoti, Mori, Shohei, Madaoui, Mimouna, Wassarman, Kelly, Zlatev, Ivan, Manoharan, Muthiah

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A Chemical Approach to Introduce 2,6-Diaminopurine and 2‑Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups von Madaoui, Mimouna, Datta, Dhrubajyoti, Wassarman, Kelly, Zlatev, Ivan, Egli, Martin, Ross, Bruce S., Manoharan, Muthiah

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