MOLECULAR MECHANISMS AND COMBINATION STRATEGIES WITH PI3K AND BTK INHIBITORS TO OVERCOME INTRINSIC AND ACQUIRED RESISTANCE IN PRECLINICAL MODELS OF ABC‐DLBCL von Paul, J., Soujon, M., Wengner, A.M., Zitzmann‐Kolbe, S., Sturz, A., Haike, K., Koh, H.M., Tan, S., Lange, M., Mumberg, D., Tan, S., Lim, S., Ziegelbauer, K., Liu, N.

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594 In vivo detection of mammary tumor and its lung metastases in the 4T1 metastasis mouse model by PET imaging using [F-18]-D-FMT (BAY 869596) von Zitzmann-Kolbe, S, Strube, A, Frisk, A.L, Tsukada, H, Gekeler, V, Graham, K, Berndorff, D

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DNA repair inhibitors sensitize cells differently to high and low LET radiation von Bannik, Kristina, Madas, Balázs, Jarke, Sabrina, Sutter, Andreas, Siemeister, Gerhard, Schatz, Christoph, Mumberg, Dominik, Zitzmann-Kolbe, Sabine

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Exploiting mesothelin in thymic carcinoma as a drug delivery target for anetumab ravtansine von Chen, Vincent, Umemura, Shigeki, Han, Yumin, Raman, Renuka, Tucker, Robin, Chahine, Joeffrey, Kim, In-Kyu, Schatz, Christoph, Zitzmann-Kolbe, Sabine, Sommer, Anette, Onda, Masanori, Lee, Trevor, He, Yongfeng, Giaccone, Giuseppe

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Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy von Lejeune, Pascale, Cruciani, Véronique, Berg-Larsen, Axel, Schlicker, Andreas, Mobergslien, Anne, Bartnitzky, Lisa, Berndt, Sandra, Zitzmann-Kolbe, Sabine, Kamfenkel, Claudia, Stargard, Stefan, Hammer, Stefanie, Jørgensen, Jennifer S, Jackerott, Malene, Nielsen, Carsten H, Schatz, Christoph A, Hennekes, Hartwig, Karlsson, Jenny, Cuthbertson, Alan S, Mumberg, Dominik, Hagemann, Urs B

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GLUT 5 is not over-expressed in breast cancer cells and patient breast cancer tissues von Gowrishankar, Gayatri, Zitzmann-Kolbe, Sabine, Junutula, Anitha, Reeves, Robert, Levi, Jelena, Srinivasan, Ananth, Bruus-Jensen, Kjerstin, Cyr, John, Dinkelborg, Ludger, Gambhir, Sanjiv S

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Challenges in optimizing a prostate carcinoma binding peptide, identified through the phage display technology von Askoxylakis, Vasileios, Zitzmann-Kolbe, Sabine, Zoller, Frederic, Altmann, Annette, Markert, Annette, Rana, Shoaib, Marr, Annabell, Mier, Walter, Debus, Jürgen, Haberkorn, Uwe

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Preclinical Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC), a Targeted Alpha Therapy for Prostate Cancer von Hammer, Stefanie, Hagemann, Urs B, Zitzmann-Kolbe, Sabine, Larsen, Aasmund, Ellingsen, Christine, Geraudie, Solene, Grant, Derek, Indrevoll, Baard, Smeets, Roger, von Ahsen, Oliver, Kristian, Alexander, Lejeune, Pascale, Hennekes, Hartwig, Karlsson, Jenny, Bjerke, Roger M, Ryan, Olav B, Cuthbertson, Alan S, Mumberg, Dominik

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Radiobiological effects of the alpha emitter Ra-223 on tumor cells von Bannik, Kristina, Madas, Balázs, Jarzombek, Marco, Sutter, Andreas, Siemeister, Gerhard, Mumberg, Dominik, Zitzmann-Kolbe, Sabine

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Simultaneous Inhibition of PI3Kδ and PI3Kα Induces ABC-DLBCL Regression by Blocking BCR-Dependent and -Independent Activation of NF-κB and AKT von Paul, Juliane, Soujon, Maurice, Wengner, Antje M., Zitzmann-Kolbe, Sabine, Sturz, Andrea, Haike, Katja, Keng Magdalene, Koh Hui, Tan, Sze Huey, Lange, Martin, Tan, Soo Yong, Mumberg, Dominik, Lim, Soon Thye, Ziegelbauer, Karl, Liu, Ningshu

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Mono- and multimeric PSMA-targeting small molecule-thorium-227 conjugates for optimized efficacy and biodistribution in preclinical models von Böhnke, Niels, Indrevoll, Bård, Hammer, Stefanie, Papple, Alex, Kristian, Alexander, Briem, Hans, Celik, Arif, Mumberg, Dominik, Cuthbertson, Alan, Zitzmann-Kolbe, Sabine

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Abstract 1776: Exploring anetumab ravtansine in a preclinical model of thymic carcinoma von Chen, Vincent, Sommer, Anette, Schatz, Christoph, Zitzmann-Kolbe, Sabine, Kim, In-Kyu, Giaccone, Giuseppe

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Abstract 6318: Acquired resistance in a malignant pleural mesothelioma preclinical model after treatment with Anetumab ravtansine von Schatz, Christoph, Zitzmann-Kolbe, Sabine, Tetzner, Reimo, Keil, Marlen, Hoffmann, Jens, Mumberg, Dominik, Sommer, Anette

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Advances in Precision Oncology: Targeted Thorium-227 Conjugates As a New Modality in Targeted Alpha Therapy von Hagemann, Urs B, Wickstroem, Katrine, Hammer, Stefanie, Bjerke, Roger M, Zitzmann-Kolbe, Sabine, Ryan, Olav B, Karlsson, Jenny, Scholz, Arne, Hennekes, Hartwig, Mumberg, Dominik, Cuthbertson, Alan S

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Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo von Siemeister, Gerhard, Mengel, Anne, Fernández-Montalván, Amaury E, Bone, Wilhelm, Schröder, Jens, Zitzmann-Kolbe, Sabine, Briem, Hans, Prechtl, Stefan, Holton, Simon J, Mönning, Ursula, von Ahsen, Oliver, Johanssen, Sandra, Cleve, Arwed, Pütter, Vera, Hitchcock, Marion, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik

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Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models von Quanz, Maria, Hagemann, Urs B, Zitzmann-Kolbe, Sabine, Stelte-Ludwig, Beatrix, Golfier, Sven, Elbi, Cem, Mumberg, Dominik, Ziegelbauer, Karl, Schatz, Christoph A

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Abstract 3927: Radium-223 α-particle radiation: Characterization of the in vitro effects on cancer cells in monotherapy and in combination with DNA repair inhibitors von Bannik, Kristina, Zitzmann-Kolbe, Sabine, Scholz, Arne, Jarke, Sabrina, Jarzombek, Marco, Sutter, Andreas, Siemeister, Gerhard, Mumberg, Dominik

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Abstract A115: Mechanisms of resistance toward the FGFR inhibitor rogaratinib in preclinical urothelial bladder cancer models von Jerchel, Isabel S, Kamburov, Atanas, Zitzmann-Kolbe, Sabine, Lesche, Ralf, Walter, Alexander, Mumberg, Dominik, Politz, Oliver, Gruenewald, Sylvia

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Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models von Hammer, Stefanie, Schlicker, Andreas, Zitzmann-Kolbe, Sabine, Baumgart, Simon, Hagemann, Urs B, Scholz, Arne, Haendler, Bernard, Lejeune, Pascale, Karlsson, Jenny, Ellingsen, Christine, Hennekes, Hartwig, Nielsen, Carsten H, Juul, Mark U, Mumberg, Dominik, Schatz, Christoph A

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A targeted thorium-227 conjugate demonstrates efficacy in preclinical models of acquired drug resistance and combination potential with chemotherapeutics and antiangiogenic therapi... von Zitzmann-Kolbe, Sabine, Kristian, Alexander, Zopf, Dieter, Kamfenkel, Claudia, Politz, Oliver, Ellingsen, Christine, Hilbig, Jochen, Juul, Mark U, Fonslet, Jesper, Nielsen, Carsten H, Schatz, Christoph A, Bjerke, Roger M, Cuthbertson, Alan S, Mumberg, Dominik, Hagemann, Urs B

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