Pharmacology and Rationale for Seralutinib in the Treatment of Pulmonary Arterial Hypertension von Pullamsetti, Soni Savai, Sitapara, Ravikumar, Osterhout, Robin, Weiss, Astrid, Carter, Laura L, Zisman, Lawrence S, Schermuly, Ralph Theo

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SU5416 plus hypoxia but not selective VEGFR2 inhibition with cabozantinib plus hypoxia induces pulmonary hypertension in rats: potential role of BMPR2 signaling von Sitapara, Ravikumar, Sugarragchaa, Chuluunbaatar, Zisman, Lawrence S.

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TORREY, a Phase 2 study to evaluate the efficacy and safety of inhaled seralutinib for the treatment of pulmonary arterial hypertension von Frantz, Robert P., Benza, Raymond L., Channick, Richard N., Chin, Kelly, Howard, Luke S., McLaughlin, Vallerie V., Sitbon, Olivier, Zamanian, Roham T., Hemnes, Anna R., Cravets, Matt, Bruey, Jean-Marie, Roscigno, Robert, Mottola, David, Elman, Erin, Zisman, Lawrence S., Ghofrani, Hossein-Ardeschir

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Role of biomarkers in evaluation, treatment and clinical studies of pulmonary arterial hypertension von Hemnes, Anna, Rothman, Alexander M.K., Swift, Andrew J., Zisman, Lawrence S.

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Inspiratory flow patterns with dry powder inhalers of low and medium flow resistance in patients with pulmonary arterial hypertension von Faria-Urbina, Mariana, Ung, Keith T., Lawler, Laurie, Zisman, Lawrence S., Waxman, Aaron B.

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Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension von Galkin, Anna, Sitapara, Ravikumar, Clemons, Bryan, Garcia, Eduardo, Kennedy, Michael, Guimond, David, Carter, Laura L, Douthitt, Ashley, Osterhout, Robin, Gandjeva, Aneta, Slee, Deborah, Salter-Cid, Luisa, Tuder, Rubin M, Zisman, Lawrence S

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Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension von Sitapara, Ravikumar, Lam, TuKiet T., Gandjeva, Aneta, Tuder, Rubin M., Zisman, Lawrence S.

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PK10453, a nonselective platelet-derived growth factor receptor inhibitor, prevents the progression of pulmonary arterial hypertension von Medarametla, Venkatrao, Festin, Stephen, Sugarragchaa, Chuluunbaatar, Eng, Alexander, Naqwi, Amir, Wiedmann, Timothy, Zisman, Lawrence S.

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Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium von Bristow, Michael R., Zisman, Lawrence S., Altman, Natasha L., Gilbert, Edward M., Lowes, Brian D., Minobe, Wayne A., Slavov, Dobromir, Schwisow, Jessica A., Rodriguez, Erin M., Carroll, Ian A., Keuer, Thomas A., Buttrick, Peter M., Kao, David P.

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Seralutinib in adults with pulmonary arterial hypertension (TORREY): a randomised, double-blind, placebo-controlled phase 2 trial von Frantz, Robert P, McLaughlin, Vallerie V, Sahay, Sandeep, Escribano Subías, Pilar, Zolty, Ronald L, Benza, Raymond L, Channick, Richard N, Chin, Kelly M, Hemnes, Anna R, Howard, Luke S, Sitbon, Olivier, Vachiéry, Jean-Luc, Zamanian, Roham T, Cravets, Matt, Roscigno, Robert F, Mottola, David, Osterhout, Robin, Bruey, Jean-Marie, Elman, Erin, Tompkins, Cindy-ann, Parsley, Ed, Aranda, Richard, Zisman, Lawrence S, Ghofrani, Hossein-Ardeschir, Adir, Yochai, Baillie, Timothy, Baratz, David, Burger, Charles, Chakinala, Murali M., Cifrián Martínez, Jose Manual, Delcroix, Marion, Dwyer, Nathan, Elwing, Jean M., Fisher, Micah, Franco, Veronica, Grünig, Ekkehard, Highland, Kristin, Hill, Nicholas, Hirani, Naushad, Hoeper, Marius, Jansa, Pavel, Keogh, Anne, Kingrey, John, Lopez-Meseguer, Manuel, McConnell, John W., Mehta, Sanjay, Melendres-Groves, Lana, Opitz, Christian, Pepke-Zaba, Joanna, Pillutla, Priya, Rahaghi, Franck, Raina, Amresh, Raviv, Yael, Robinson, Jeffrey, Ryan, John, Sager, Jeffrey, Shapiro, Shelley, Simon, Marc, Smith, Kerri, Sobol, Irina R., Sood, Namita, Spikes, Leslie A., Stadler, Stefan, Stevens, Wendy, Sulica, Roxana, White, R. James

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Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: Evidence for upregulation of the angiotensin-converting enzyme homologue ACE2 von ZISMAN, Lawrence S, KELLER, Rebecca S, WEAVER, Barbara, QISHAN LIN, SPETH, Robert, BRISTOW, Michael R, CANVER, Charles C

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Combined Oral Positive Inotropic and Beta-Blocker Therapy for Treatment of Refractory Class IV Heart Failure von Shakar, Simon F, Abraham, William T, Gilbert, Edward M, Robertson, Alastair D, Lowes, Brian D, Zisman, Lawrence S, Ferguson, Debra A, Bristow, Michael R

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The Pressure-Overloaded Right Ventricle in Pulmonary Hypertension von Bristow, Michael R., Zisman, Lawrence S., Lowes, Brian D., Abraham, William T., Badesch, David B., Groves, Bertron M., Voelkel, Norbert F., Lynch, David M.B., Quaife, Robert A.

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Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium von ASANO, K, DUTCHER, D. L, RAYNOLDS, M. V, ZISMAN, L. S, PERRYMAN, M. B, BRISTOW, M. R, PORT, J. D, MINOBE, W. A, TREMMEL, K. D, RODEN, R. L, BOHLMEYER, T. J, BUSH, E. W, JENKIN, M. J, ABRAHAM, W. T

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ACE and ACE2: a tale of two enzymes von Zisman, Lawrence S

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Angiotensin-(1-7) formation in the intact human heart: In vivo dependence on angiotensin II as substrate von ZISMAN, Lawrence S, MEIXELL, Glenn E, BRISTOW, Michael R, CANVER, Charles C

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Interaction of ACE2 and integrin β1 in failing human heart von Lin, Qishan, Keller, Rebecca S., Weaver, Barbara, Zisman, Lawrence S.

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Myocardial infarction increases ACE2 expression in rat and humans: reply von Zisman, Lawrence S.

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REAL-WORLD REFERRAL PATTERNS OF PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION (PAH) TO PULMONARY HYPERTENSION ASSOCIATION (PHA)-ACCREDITED COMPREHENSIVE CARE CENTERS IN THE STATE O... von KINGMAN, MARTHA S, CHIN, KELLY, NELSON, GINA, F ROSCIGNO, ROBERT, MOTTOLA, DAVID, S ZISMAN, LAWRENCE, UMEH, EMEKA, SAHAY, SANDEEP

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Low-dose oral enoximone enhances the ability to wean patients with ultra-advanced heart failure from intravenous inotropic support: Results of the oral enoximone in intravenous ino... von Feldman, Arthur M., MD, PhD, Oren, Ron M., MD, Abraham, William T., MD, Boehmer, John P., MD, Carson, Peter E., MD, Eichhorn, Eric, MD, Gilbert, Edward M., MD, Kao, Andrew, MD, Leier, Carl V., MD, Lowes, Brian D., MD, Mathier, Michael A., MD, McGrew, Frank A., MD, Metra, Marco, MD, Zisman, Lawrence S., MD, Shakar, Simon F., MD, Krueger, Steven K., MD, Robertson, Alastair D., PhD, White, Bill G., PhD, Gerber, Michael J., MD, Wold, Gwyn E., MSPH, Bristow, Michael R., MD, PhD

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