Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic... von Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L

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Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells von Liu, Guang, Shea, Courtney M., Jones, Juli E., Price, Gavrielle M., Warren, William, Lonie, Elisabeth, Yan, Shu, Currie, Mark G., Profy, Albert T., Masferrer, Jaime L., Zimmer, Daniel P.

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An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension von Hanrahan, John P., Seferovic, Jelena P., Wakefield, James D., Wilson, Phebe J., Chickering, Jennifer G., Jung, Joon, Carlson, Kenneth E., Zimmer, Daniel P., Frelinger, Andrew L., Michelson, Alan D., Morrow, Linda, Hall, Michael, Currie, Mark G., Milne, G. Todd, Profy, Albert T.

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The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo von Zimmer, Daniel P, Silva, Ines A, Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark

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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease von Zimmer, Daniel P., Shea, Courtney M., Tobin, Jenny V., Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R., Jacobson, Sarah, Bernier, Sylvie G., Sarno, Renee, Carvalho, Andrew, Chien, Yueh-tyng, Graul, Regina, Buys, Emmanuel S., Jones, Juli E., Wakefield, James D., Price, Gavrielle M., Chickering, Jennifer G., Milne, G. Todd, Currie, Mark G., Masferrer, Jaime L.

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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator von Rennie, Glen R., Barden, Timothy C., Bernier, Sylvie G., Carvalho, Andrew, Deming, Renee, Germano, Peter, Hudson, Colleen, Im, G-Yoon J., Iyengar, Rajesh R., Jia, Lei, Jung, Joon, Kim, Elise, Lee, Thomas W.-H., Mermerian, Ara, Moore, Joel, Nakai, Takashi, Perl, Nicholas R., Tobin, Jenny, Zimmer, Daniel P., Renhowe, Paul A.

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An impaired natriuretic peptide hormone system may play a role in COVID‐19 severity in vulnerable populations von Currie, Mark G., Zimmer, Daniel P., Halushka, Perry V.

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Nitrogen Regulatory Protein C-Controlled Genes of Escherichia coli: Scavenging as a Defense against Nitrogen Limitation von Zimmer, D P, Soupene, E, Lee, H L, Wendisch, V F, Khodursky, A B, Peter, B J, Bender, R A, Kustu, S

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Structural Origins of Adenine-Tract Bending von Barbič, Andrej, Zimmer, Daniel P., Crothers, Donald M.

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Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains von Madden, Kevin T, Askenazi, Manor, Driggers, Edward M, Holtzman, Douglas A, Norman, Thea C, Iverson, Sara, Zimmer, Daniel P, Boers, Mary-Ellen, Blomquist, Paul R, Martinez, Eduardo J, Monreal, Alex W, Feibelman, Toby P, Mayorga, Maria E, Maxon, Mary E, Sykes, Kristie, Tobin, Jenny Vittum, Cordero, Etchell, Salama, Sofie R, Trueheart, Joshua, Royer, John C

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Long-term treatment, tolerability, and survival with sub-cutaneous treprostinil for severe pulmonary hypertension von Sadushi-Koliçi, Roela, MD, Skoro-Sajer, Nika, MD, Zimmer, Daniel, MD, Bonderman, Diana, MD, Schemper, Michael, PhD, Klepetko, Walter, MD, Glatz, Jutta, MSc, Jakowitsch, Johannes, PhD, Lang, Irene M., MD

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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats von Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.

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Quantitative mass balance, tissue distribution, pharmacokinetics and biotransformation pathway of praliciguat, a clinical-stage sgc stimulator, after oral administration in rats von Banijamali, Ali, Carvalho, Andrew, Wakefield, James, Germano, Peter, Ribadeneira, Maria, Barden, Timothy, Zimmer, Daniel, Masferrer, Jaime, Profy, Albert, Currie, Mark, Milne, Todd

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Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans von Nakai, Takashi, Perl, Nicholas R, Barden, Timothy C, Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J, Jin, Hong, Kim, Charles, Lee, Thomas W.-H, Long, Kimberly, Moore, Joel, Rohde, Jason M, Sarno, Renee, Segal, Chrissie, Solberg, Erik O, Tobin, Jenny, Zimmer, Daniel P, Currie, Mark G

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Optimization of a tabletop high-repetition-rate soft x-ray laser pumped in double-pulse single-beam grazing incidence von ZIMMER, Daniel, ZIELBAUER, Bernhard, PITTMAN, Moana, GUILBAUD, Olivier, HABIB, Jamil, KAZAMIAS, Sophie, ROS, David, BAGNOUD, Vincent, KUEHL, Thomas

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Enforcement of the Digital Markets Act - The European Commission Takes Action von Daniel Zimmer, Jan-Frederick Göhsl

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The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers von Moss, Nicholas G, Riguera, Dorothy A, Solinga, Robert M, Kessler, Marco M, Zimmer, Daniel P, Arendshorst, William J, Currie, Mark G, Goy, Michael F

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Efficacy and Safety of OC-01 (Varenicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The ONSET-2 Phase 3 Randomized Trial von Wirta, David, Vollmer, Patrick, Paauw, James, Chiu, Kuei-Hsun, Henry, Eugenia, Striffler, Kristen, Nau, Jeffrey

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Isolation of Escherichia coli mRNA and Comparison of Expression Using mRNA and Total RNA on DNA Microarrays von Wendisch, Volker F, Zimmer, Daniel P, Khodursky, Arkady, Peter, Brian, Cozzarelli, Nicholas, Kustu, Sydney

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The Emancipation of Antitrust from Market-Share-Based Approaches von Zimmer, Daniel

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