Primary Cell Cultures from the Mouse Retinal Pigment Epithelium von Shang, Peng, Stepicheva, Nadezda A, Hose, Stacey, Zigler, Jr, J Samuel, Sinha, Debasish

Volltext

Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy von Liu, Haitao, Ghosh, Sayan, Vaidya, Tanuja, Bammidi, Sridhar, Huang, Chao, Shang, Peng, Nair, Archana Padmanabhan, Chowdhury, Olivia, Stepicheva, Nadezda A, Strizhakova, Anastasia, Hose, Stacey, Mitrousis, Nikolaos, Gadde, Santosh Gopikrishna, Mb, Thirumalesh, Strassburger, Pamela, Widmer, Gabriella, Lad, Eleonora M, Fort, Patrice E, Sahel, José-Alain, Zigler, Jr, J Samuel, Sethu, Swaminathan, Westenskow, Peter D, Proia, Alan D, Sodhi, Akrit, Ghosh, Arkasubhra, Feenstra, Derrick, Sinha, Debasish

Volltext

Role of glia in optic nerve von Yazdankhah, Meysam, Shang, Peng, Ghosh, Sayan, Hose, Stacey, Liu, Haitao, Weiss, Joseph, Fitting, Christopher S., Bhutto, Imran A., Zigler, J. Samuel, Qian, Jiang, Sahel, José-Alain, Sinha, Debasish, Stepicheva, Nadezda A.

Volltext

The role of lipocalin-2 in age-related macular degeneration (AMD) von Ghosh, Sayan, Stepicheva, Nadezda, Yazdankhah, Meysam, Shang, Peng, Watson, Alan M., Hose, Stacey, Liu, Haitao, Weiss, Joseph, Zigler, J. Samuel, Valapala, Mallika, Watkins, Simon C., Sinha, Debasish

Volltext

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat von Zigler, J. Samuel Jr, Zhang, Cheng, Grebe, Rhonda, Sehrawat, Gitanjali, Hackler, Laszlo Jr, Adhya, Souvonik, Hose, Stacey, McLeod, D. Scott, Bhutto, Imran, Barbour, Walid, Parthasarathy, Geetha, Zack, Donald J, Sergeev, Yuri, Lutty, Gerard A, Handa, James T, Sinha, Debasish

Volltext

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration von Ghosh, Sayan, Padmanabhan, Archana, Vaidya, Tanuja, Watson, Alan M., Bhutto, Imran A., Hose, Stacey, Shang, Peng, Stepicheva, Nadezda, Yazdankhah, Meysam, Weiss, Joseph, Das, Manjula, Gopikrishna, Santosh, Aishwarya, Yadav, Naresh, Berger, Thorsten, Mak, Tak W., Xia, Shuli, Qian, Jiang, Lutty, Gerard A., Jayagopal, Ashwath, Zigler, J. Samuel, Sethu, Swaminathan, Handa, James T., Watkins, Simon C., Ghosh, Arkasubhra, Sinha, Debasish

Volltext

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes von Valapala, Mallika, Edwards, Malia, Hose, Stacey, Hu, Jianfei, Wawrousek, Eric, Lutty, Gerard A., Zigler, Jr, J. Samuel, Qian, Jiang, Sinha, Debasish

Volltext

Expression pattern of an evolutionarily conserved splice variant in the rat Tacc2 gene von Padhi, Bhaja K., Zigler Jr, J. Samuel, Padhi, Piyush, Hose, Stacey, Sinha, Debasish

Volltext

βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity von Ghosh, Sayan, Liu, Haitao, Yazdankhah, Meysam, Stepicheva, Nadezda, Shang, Peng, Vaidya, Tanuja, Hose, Stacey, Gupta, Urvi, Calderon, Michael Joseph, Hu, Ming-Wen, Nair, Archana Padmanabhan, Weiss, Joseph, Fitting, Christopher S., Bhutto, Imran A., Gadde, Santosh Gopi Krishna, Naik, Naveen Kumar, Jaydev, Chaitra, Lutty, Gerard A., Handa, James T., Jayagopal, Ashwath, Qian, Jiang, Sahel, José-Alain, Rajasundaram, Dhivyaa, Sergeev, Yuri, Zigler, J. Samuel, Sethu, Swaminathan, Watkins, Simon, Ghosh, Arkasubhra, Sinha, Debasish

Volltext

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD von Gupta, Urvi, Ghosh, Sayan, Wallace, Callen T., Shang, Peng, Xin, Ying, Nair, Archana Padmanabhan, Yazdankhah, Meysam, Strizhakova, Anastasia, Ross, Mark A., Liu, Haitao, Hose, Stacey, Stepicheva, Nadezda A., Chowdhury, Olivia, Nemani, Mihir, Maddipatla, Vishnu, Grebe, Rhonda, Das, Manjula, Lathrop, Kira L., Sahel, José-Alain, Zigler, J. Samuel, Qian, Jiang, Ghosh, Arkasubhra, Sergeev, Yuri, Handa, James T., St. Croix, Claudette M., Sinha, Debasish

Volltext

βA3/A1-crystallin: More than a lens protein von Zigler, J. Samuel, Sinha, Debasish

Volltext

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration von Ghosh, Sayan, Shang, Peng, Terasaki, Hiroto, Stepicheva, Nadezda, Hose, Stacey, Yazdankhah, Meysam, Weiss, Joseph, Sakamoto, Taiji, Bhutto, Imran A, Xia, Shuli, Zigler, Jr, J Samuel, Kannan, Ram, Qian, Jiang, Handa, James T, Sinha, Debasish

Volltext

BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes von Yazdankhah, Meysam, Ghosh, Sayan, Shang, Peng, Stepicheva, Nadezda, Hose, Stacey, Liu, Haitao, Chamling, Xitiz, Tian, Shenghe, Sullivan, Mara L.G., Calderon, Michael Joseph, Fitting, Christopher S., Weiss, Joseph, Jayagopal, Ashwath, Handa, James T., Sahel, José-Alain, Zigler, J. Samuel, Kinchington, Paul R., Zack, Donald J., Sinha, Debasish

Volltext

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium von Sinha, Debasish, Valapala, Mallika, Shang, Peng, Hose, Stacey, Grebe, Rhonda, Lutty, Gerard A., Zigler, J. Samuel, Kaarniranta, Kai, Handa, James T.

Volltext

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy von Liu, Haitao, Stepicheva, Nadezda A., Ghosh, Sayan, Shang, Peng, Chowdhury, Olivia, Daley, Rachel A., Yazdankhah, Meysam, Gupta, Urvi, Hose, Stacey L., Valapala, Mallika, Fitting, Christopher Scott, Strizhakova, Anastasia, Shan, Yang, Feenstra, Derrick, Sahel, José-Alain, Jayagopal, Ashwath, Handa, James T., Zigler, J. Samuel, Fort, Patrice E., Sodhi, Akrit, Sinha, Debasish

Volltext

Activating the AKT2–nuclear factor‐κB–lipocalin‐2 axis elicits an inflammatory response in age‐related macular degeneration von Ghosh, Sayan, Shang, Peng, Yazdankhah, Meysam, Bhutto, Imran, Hose, Stacey, Montezuma, Sandra R, Luo, Tianqi, Chattopadhyay, Sreya, Qian, Jiang, Lutty, Gerard A, Ferrington, Deborah A, Zigler, Jr, J Samuel, Sinha, Debasish

Volltext

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling von Valapala, Mallika, Wilson, Christine, Hose, Stacey, Bhutto, Imran A, Grebe, Rhonda, Dong, Aling, Greenbaum, Seth, Gu, Limin, Sengupta, Samhita, Cano, Marisol, Hackett, Sean, Xu, Guotong, Lutty, Gerard A, Dong, Lijin, Sergeev, Yuri, Handa, James T, Campochiaro, Peter, Wawrousek, Eric, Zigler, Jr, J Samuel, Sinha, Debasish

Volltext

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD von Ghosh, Sayan, Sharma, Ruchi, Bammidi, Sridhar, Koontz, Victoria, Nemani, Mihir, Yazdankhah, Meysam, Kedziora, Katarzyna M., Stolz, Donna Beer, Wallace, Callen T., Yu-Wei, Cheng, Franks, Jonathan, Bose, Devika, Shang, Peng, Ambrosino, Helena M., Dutton, James R., Geng, Zhaohui, Montford, Jair, Ryu, Jiwon, Rajasundaram, Dhivyaa, Hose, Stacey, Sahel, José-Alain, Puertollano, Rosa, Finkel, Toren, Zigler, J. Samuel, Sergeev, Yuri, Watkins, Simon C., Goetzman, Eric S., Ferrington, Deborah A., Flores-Bellver, Miguel, Kaarniranta, Kai, Sodhi, Akrit, Bharti, Kapil, Handa, James T., Sinha, Debasish

Volltext

A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD von Shang, Peng, Stepicheva, Nadezda A., Liu, Haitao, Chowdhury, Olivia, Franks, Jonathan, Sun, Ming, Hose, Stacey, Ghosh, Sayan, Yazdankhah, Meysam, Strizhakova, Anastasia, Stolz, Donna Beer, Zigler, J. Samuel, Sinha, Debasish

Volltext

A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems von Zigler, Jr, J Samuel, Hodgkinson, Colin A, Wright, Megan, Klise, Andrew, Sundin, Olof, Broman, Karl W, Hejtmancik, Fielding, Huang, Hao, Patek, Bonnie, Sergeev, Yuri, Hose, Stacey, Brayton, Cory, Xaiodong, Jiao, Vasquez, David, Maragakis, Nicholas, Mori, Susumu, Goldman, David, Hoke, Ahmet, Sinha, Debasish

Volltext