High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology von Lin, Xudong, Duan, Xin, Jacobs, Claire, Ullmann, Jeremy, Chan, Chung-Yuen, Chen, Siya, Cheng, Shuk-Han, Zhao, Wen-Ning, Poduri, Annapurna, Wang, Xin, Haggarty, Stephen J., Shi, Peng

Volltext

Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation von Zhou, Zhaolan, Hong, Elizabeth J., Cohen, Sonia, Zhao, Wen-ning, Ho, Hsin-yi Henry, Schmidt, Lauren, Chen, Wen G., Lin, Yingxi, Savner, Erin, Griffith, Eric C., Hu, Linda, Steen, Judith A.J., Weitz, Charles J., Greenberg, Michael E.

Volltext

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability von Lalonde, Jasmin, Reis, Surya A., Sivakumaran, Sudhir, Holland, Carl S., Wesseling, Hendrik, Sauld, John F., Alural, Begum, Zhao, Wen-Ning, Steen, Judith A., Haggarty, Stephen J.

Volltext

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia von She, Angela, Kurtser, Iren, Reis, Surya A., Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C., Herz, Joachim, Haggarty, Stephen J.

Volltext

Deep Learning Benchmarks on L1000 Gene Expression Data von McDermott, Matthew B.A., Wang, Jennifer, Zhao, Wen-Ning, Sheridan, Steven D., Szolovits, Peter, Kohane, Isaac, Haggarty, Stephen J., Perlis, Roy H.

Volltext

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory von Zhao, Wen-Ning, Ghosh, Balaram, Tyler, Marshall, Lalonde, Jasmin, Joseph, Nadine F, Kosaric, Nina, Fass, Daniel M, Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J

Volltext

Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion von Zhao, Wen-Ning, Tobe, Brian T. D., Udeshi, Namrata D., Xuan, Lucius L., Pernia, Cameron D., Zolg, Daniel P., Roberts, Amanda J., Mani, Deepak, Blumenthal, Sarah R., Kurtser, Iren, Patnaik, Debasis, Gaisina, Irina, Bishop, Joshua, Sheridan, Steven D., Lalonde, Jasmin, Carr, Steven A., Snyder, Evan Y., Haggarty, Stephen J.

Volltext

A screen for regulators of survival of motor neuron protein levels von Makhortova, Nina R, Hayhurst, Monica, Cerqueira, Antonio, Sinor-Anderson, Amy D, Zhao, Wen-Ning, Heiser, Patrick W, Arvanites, Anthony C, Davidow, Lance S, Waldon, Zachary O, Steen, Judith A, Lam, Kelvin, Ngo, Hien D, Rubin, Lee L

Volltext

HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination von Strebl, Martin G, Campbell, Arthur J, Zhao, Wen-Ning, Schroeder, Frederick A, Riley, Misha M, Chindavong, Peter S, Morin, Thomas M, Haggarty, Stephen J, Wagner, Florence F, Ritter, Tobias, Hooker, Jacob M

Volltext

CIPC is a mammalian circadian clock protein without invertebrate homologues von Weitz, Charles J, Zhao, Wen-Ning, Malinin, Nikolay, Yang, Fu-Chia, Staknis, David, Gekakis, Nicholas, Maier, Bert, Reischl, Silke, Kramer, Achim

Volltext

Porous Light-Emitting Diodes With Patterned Sapphire Substrates Realized by High-Voltage Self-Growth and Soft UV Nanoimprint Processes von Sun, Tang-You, Zhao, Wen-Ning, Wu, Xing-Hui, Liu, Si-Si, Ma, Zhi-Chao, Peng, Jing, He, Jian, Xu, Hai-Feng, Liu, Shi-Yuan, Xu, Zhi-Mou

Volltext

An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration von Petcherski, Anton, Chandrachud, Uma, Butz, Elisabeth S, Klein, Madeleine C, Zhao, Wen-Ning, Reis, Surya A, Haggarty, Stephen J, Ruonala, Mika O, Cotman, Susan L

Volltext

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin von Fass, Daniel M, Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A, Klein, Peter S, Mazitschek, Ralph, Maglathlin, Rebecca L, Lewis, Timothy A, Haggarty, Stephen J

Volltext

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function von Chandrachud, Uma, Walker, Mathew W., Simas, Alexandra M., Heetveld, Sasja, Petcherski, Anton, Klein, Madeleine, Oh, Hyejin, Wolf, Pavlina, Zhao, Wen-Ning, Norton, Stephanie, Haggarty, Stephen J., Lloyd-Evans, Emyr, Cotman, Susan L.

Volltext

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery von Bernard-Gauthier, Vadim, Mossine, Andrew V, Knight, Ashley, Patnaik, Debasis, Zhao, Wen-Ning, Cheng, Chialin, Krishnan, Hema S, Xuan, Lucius L, Chindavong, Peter S, Reis, Surya A, Chen, Jinshan Michael, Shao, Xia, Stauff, Jenelle, Arteaga, Janna, Sherman, Phillip, Salem, Nicolas, Bonsall, David, Amaral, Brenda, Varlow, Cassis, Wells, Lisa, Martarello, Laurent, Patel, Shil, Liang, Steven H, Kurumbail, Ravi G, Haggarty, Stephen J, Scott, Peter J. H, Vasdev, Neil

Volltext

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate von Zaldivar-Diez, Josefa, Li, Lingling, Garcia, Ana M, Zhao, Wen-Ning, Medina-Menendez, Cristina, Haggarty, Stephen. J, Gil, Carmen, Morales, Aixa V, Martinez, Ana

Volltext

Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA) von Zhao, Wen-Ning, Hylton, Norma K., Wang, Jennifer, Chindavong, Peter S., Alural, Begum, Kurtser, Iren, Subramanian, Aravind, Mazitschek, Ralph, Perlis, Roy H., Haggarty, Stephen J.

Volltext

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors von Wagner, Florence F., Weïwer, Michel, Steinbacher, Stefan, Schomburg, Adrian, Reinemer, Peter, Gale, Jennifer P., Campbell, Arthur J., Fisher, Stewart L., Zhao, Wen-Ning, Reis, Surya A., Hennig, Krista M., Thomas, Méryl, Müller, Peter, Jefson, Martin R., Fass, Daniel M., Haggarty, Stephen J., Zhang, Yan-Ling, Holson, Edward B.

Volltext

Chemically targeting the redox switch in AP1 transcription factor ΔFOSB von Kumar, Ashwani, Aglyamova, Galina, Yim, Yun Young, Bailey, Aaron O, Lynch, Haley M, Powell, Reid T, Nguyen, Nghi D, Rosenthal, Zachary, Zhao, Wen-Ning, Li, Yi, Chen, Jianping, Fan, Shanghua, Lee, Hubert, Russell, William K, Stephan, Clifford, Robison, Alfred J, Haggarty, Stephen J, Nestler, Eric J, Zhou, Jia, Machius, Mischa, Rudenko, Gabby

Volltext

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests von Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L

Volltext