Therapeutic Targeting of Oncogenic Tyrosine Phosphatases von Frankson, Rochelle, Yu, Zhi-Hong, Bai, Yunpeng, Li, Qinglin, Zhang, Ruo-Yu, Zhang, Zhong-Yin

Volltext

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases von Yu, Zhi-Hong, Zhang, Zhong-Yin

Volltext

Protein tyrosine phosphatases as potential therapeutic targets von He, Rong-jun, Yu, Zhi-hong, Zhang, Ruo-yu, Zhang, Zhong-yin

Volltext

Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation von Miao, Jinmin, Zhang, Zhong-Yin

Volltext

PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours von Wiede, Florian, Lu, Kun‐Hui, Du, Xin, Liang, Shuwei, Hochheiser, Katharina, Dodd, Garron T, Goh, Pei K, Kearney, Conor, Meyran, Deborah, Beavis, Paul A, Henderson, Melissa A, Park, Simone L, Waithman, Jason, Zhang, Sheng, Zhang, Zhong‐Yin, Oliaro, Jane, Gebhardt, Thomas, Darcy, Phillip K, Tiganis, Tony

Volltext

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling von Zhang, Zhong-Yin, Dodd, Garron T, Tiganis, Tony

Volltext

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy von Qu, Zihan, Dong, Jiajun, Zhang, Zhong-Yin

Volltext

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy von Dong, Jiajun, Miao, Jinmin, Miao, Yiming, Qu, Zihan, Zhang, Sheng, Zhu, Peipei, Wiede, Florian, Jassim, Brenson A., Bai, Yunpeng, Nguyen, Quyen, Lin, Jianping, Chen, Lan, Tiganis, Tony, Tao, W. Andy, Zhang, Zhong‐Yin

Volltext

SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer von Chen, Hao, Libring, Sarah, Ruddraraju, Kasi Viswanatharaju, Miao, Jinmin, Solorio, Luis, Zhang, Zhong-Yin, Wendt, Michael K.

Volltext

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation von Zhu, Guangya, Xie, Jingjing, Kong, Wenna, Xie, Jingfei, Li, Yichen, Du, Lin, Zheng, Qiangang, Sun, Lin, Guan, Mingfeng, Li, Huan, Zhu, Tianxin, He, Hao, Liu, Zhenying, Xia, Xi, Kan, Chen, Tao, Youqi, Shen, Hong C., Li, Dan, Wang, Siying, Yu, Yongguo, Yu, Zhi-Hong, Zhang, Zhong-Yin, Liu, Cong, Zhu, Jidong

Volltext

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases von Hamerman, Jessica A., Pottle, Jessica, Ni, Minjian, He, Yantao, Zhang, Zhong-Yin, Buckner, Jane H.

Volltext

Small molecule tools for functional interrogation of protein tyrosine phosphatases von He, Rongjun, Zeng, Li‐Fan, He, Yantao, Zhang, Sheng, Zhang, Zhong‐Yin

Volltext

Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases von Zhang, Zhong-Yin

Volltext

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis von Bunda, Severa, Burrell, Kelly, Heir, Pardeep, Zeng, Lifan, Alamsahebpour, Amir, Kano, Yoshihito, Raught, Brian, Zhang, Zhong-Yin, Zadeh, Gelareh, Ohh, Michael

Volltext

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis von Zehender, Ariella, Huang, Jingang, Györfi, Andrea-Hermina, Matei, Alexandru-Emil, Trinh-Minh, Thuong, Xu, Xiaohan, Li, Yi-Nan, Chen, Chih-Wei, Lin, Jianping, Dees, Clara, Beyer, Christian, Gelse, Kolja, Zhang, Zhong-Yin, Bergmann, Christina, Ramming, Andreas, Birchmeier, Walter, Distler, Oliver, Schett, Georg, Distler, Jörg H. W.

Volltext

Quinic Acid‐Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins von Xu, Jun, Lee, Steve Seung‐Young, Seo, Howon, Pang, Liang, Jun, Yearin, Zhang, Ruo‐Yu, Zhang, Zhong‐Yin, Kim, Pilhan, Lee, Wooin, Kron, Stephen J., Yeo, Yoon

Volltext

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation von Kano, Yoshihito, Gebregiworgis, Teklab, Marshall, Christopher B., Radulovich, Nikolina, Poon, Betty P. K., St-Germain, Jonathan, Cook, Jonathan D., Valencia-Sama, Ivette, Grant, Benjamin M. M., Herrera, Silvia Gabriela, Miao, Jinmin, Raught, Brian, Irwin, Meredith S., Lee, Jeffrey E., Yeh, Jen Jen, Zhang, Zhong-Yin, Tsao, Ming-Sound, Ikura, Mitsuhiko, Ohh, Michael

Volltext

Insulin regulates POMC neuronal plasticity to control glucose metabolism von Dodd, Garron T, Michael, Natalie J, Lee-Young, Robert S, Mangiafico, Salvatore P, Pryor, Jack T, Munder, Astrid C, Simonds, Stephanie E, Brüning, Jens Claus, Zhang, Zhong-Yin, Cowley, Michael A, Andrikopoulos, Sofianos, Horvath, Tamas L, Spanswick, David, Tiganis, Tony

Volltext

Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development von Zhang, Zhong-Yin

Volltext

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity von Miao, Jinmin, Bai, Yunpeng, Miao, Yiming, Qu, Zihan, Dong, Jiajun, Zhang, Ruo-Yu, Aggarwal, Devesh, Jassim, Brenson A, Nguyen, Quyen, Zhang, Zhong-Yin

Volltext