5‑(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)­pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Ca... von Beaufils, Florent, Cmiljanovic, Natasa, Cmiljanovic, Vladimir, Bohnacker, Thomas, Melone, Anna, Marone, Romina, Jackson, Eileen, Zhang, Xuxiao, Sele, Alexander, Borsari, Chiara, Mestan, Jürgen, Hebeisen, Paul, Hillmann, Petra, Giese, Bernd, Zvelebil, Marketa, Fabbro, Doriano, Williams, Roger L, Rageot, Denise, Wymann, Matthias P

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Structural basis for activation and inhibition of class I phosphoinositide 3-kinases von Vadas, Oscar, Burke, John E, Zhang, Xuxiao, Berndt, Alex, Williams, Roger L

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Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity von Xu, Guanlong, Zhang, Xuxiao, Gao, Weihua, Wang, Chenxi, Wang, Jinliang, Sun, Honglei, Sun, Yipeng, Guo, Lu, Zhang, Rui, Chang, Kin-Chow, Liu, Jinhua, Pu, Juan

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Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets von Sun, Honglei, Pu, Juan, Wei, Yandi, Sun, Yipeng, Hu, Jiao, Liu, Litao, Xu, Guanlong, Gao, Weihua, Li, Chong, Zhang, Xuxiao, Huang, Yinhua, Chang, Kin-Chow, Liu, Xiufan, Liu, Jinhua

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A Rationally Designed H5 Hemagglutinin Subunit Vaccine Provides Broad-Spectrum Protection against Various H5Nx Highly Pathogenic Avian Influenza Viruses in Chickens von Zhang, Xuxiao, Zhang, Fushou, Chen, Ning, Cui, Xiaoping, Guo, Xiaoqin, Sun, Zhi, Guo, Pengju, Liao, Ming, Li, Xin

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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs von Rathinaswamy, Manoj K., Jenkins, Meredith L., Duewell, Benjamin R., Zhang, Xuxiao, Harris, Noah J., Evans, John T., Stariha, Jordan T.B., Dalwadi, Udit, Fleming, Kaelin D., Ranga-Prasad, Harish, Yip, Calvin K., Williams, Roger L., Hansen, Scott D., Burke, John E.

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PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control von Walser, Romy, Burke, John E, Gogvadze, Elena, Bohnacker, Thomas, Zhang, Xuxiao, Hess, Daniel, Küenzi, Peter, Leitges, Michael, Hirsch, Emilio, Williams, Roger L, Laffargue, Muriel, Wymann, Matthias P

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An improved indicator of simulated grassland production based on MODIS NDVI and GPP data: A case study in the Sichuan province, China von Fu, Xinyu, Tang, Chuanjiang, Zhang, Xuxiao, Fu, Jingying, Jiang, Dong

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Serological survey of canine H3N2, pandemic H1N1/09, and human seasonal H3N2 influenza viruses in cats in northern China, 2010–2014 von Zhang, Xuxiao, Shen, Ye, Du, Lijie, Wang, Ran, Jiang, Bo, Sun, Honglei, Pu, Juan, Lin, Degui, Wang, Ming, Liu, Jinhua, Sun, Yipeng

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An R195K Mutation in the PA-X Protein Increases the Virulence and Transmission of Influenza A Virus in Mammalian Hosts von Sun, Yipeng, Hu, Zhe, Zhang, Xuxiao, Chen, Mingyue, Wang, Zhen, Xu, Guanlong, Bi, Yuhai, Tong, Qi, Wang, Mingyang, Sun, Honglei, Pu, Juan, Iqbal, Munir, Liu, Jinhua

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Experimental Study of a New Pneumatic Actuating System Using Exhaust Recycling von Yu, Qihui, Zhai, Jianwei, Wang, Qiancheng, Zhang, Xuxiao, Tan, Xin

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Assessment of the risk posed to Singapore by the emergence of artemisinin-resistant malaria in the Greater Mekong Subregion von Zhang, Emma Xuxiao, Chavatte, Jean-Marc, Yi, Cherie See Xin, Tow, Charlene, Ying, Wong Jia, Khan, Kamran, Oh, Olivia Seen Huey, Chin, Sarah Ngeet Mei, Xin, Khong Wei, Said, Zubaidah, James, Lyn, Cutter, Jeffery, Ho, Marc, Tey, Jeannie Su Hui

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Neurovirulence of Avian Influenza Virus Is Dependent on the Interaction of Viral NP Protein with FMRP in the Murine Brain von Zhang, Xuxiao, Pu, Juan, Sun, Yipeng, Bi, Yuhai, Jiang, Zhimin, Xu, Guanlong, Zhang, Hongyu, Cao, Jing, Chang, Kin-Chow, Liu, Jinhua, Sun, Honglei

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Assessment of the risk posed to Singapore by the 2015 Middle East respiratory syndrome outbreak in the Republic of Korea von Zhang, Emma Xuxiao, Oh, Olivia Seen Huey, See, Wanhan, Raj, Pream, James, Lyn, Khan, Kamran, Tey, Jeannie Su Hui

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Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism von Zhang, Xuxiao, Vadas, Oscar, Perisic, Olga, Anderson, Karen E., Clark, Jonathan, Hawkins, Phillip T., Stephens, Len R., Williams, Roger L.

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Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations von Zhang, Xuxiao, Xu, Guanlong, Wang, Chenxi, Jiang, Ming, Gao, Weihua, Wang, Mingyang, Sun, Honglei, Sun, Yipeng, Chang, Kin-Chow, Liu, Jinhua, Pu, Juan

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Leveraging social networking sites for disease surveillance and public sensing: the case of the 2013 avian influenza A(H7N9) outbreak in China von Zhang, Emma Xuxiao, Yang, Yinping, Di Shang, Richard, Simons, Joseph John Pyne, Quek, Boon Kiat, Yin, Xiao Feng, See, Wanhan, Oh, Olivia Seen Huey, Nandar, Khine Sein Tun, Ling, Vivienne Ruo Yun, Chan, Pei Pei, Wang, Zhaoxia, Goh, Rick Siow Mong, James, Lyn, Tey, Jeannie Su Hui

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PA-X protein contributes to virulence of triple-reassortant H1N2 influenza virus by suppressing early immune responses in swine von Xu, Guanlong, Zhang, Xuxiao, Liu, Qinfang, Bing, Guoxia, Hu, Zhe, Sun, Honglei, Xiong, Xin, Jiang, Ming, He, Qiming, Wang, Yu, Pu, Juan, Guo, Xin, Yang, Hanchun, Liu, Jinhua, Sun, Yipeng

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Truncation of C-terminal 20 amino acids in PA-X contributes to adaptation of swine influenza virus in pigs von Xu, Guanlong, Zhang, Xuxiao, Sun, Yipeng, Liu, Qinfang, Sun, Honglei, Xiong, Xin, Jiang, Ming, He, Qiming, Wang, Yu, Pu, Juan, Guo, Xin, Yang, Hanchun, Liu, Jinhua

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A serological survey of canine H3N2, pandemic H1N1/09 and human seasonal H3N2 influenza viruses in dogs in China von Sun, Yipeng, Shen, Ye, Zhang, Xuxiao, Wang, Qian, Liu, Linqing, Han, Xue, Jiang, Bo, Wang, Ran, Sun, Honglei, Pu, Juan, Lin, Degui, Xia, Zhaofei, Liu, Jinhua

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