The immunological and metabolic landscape in primary and metastatic liver cancer von Li, Xin, Ramadori, Pierluigi, Pfister, Dominik, Seehawer, Marco, Zender, Lars, Heikenwalder, Mathias

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Charting a path from ‘bench to bedside’ von Zender, Lars

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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence von Glück, Selene, Guey, Baptiste, Gulen, Muhammet Fatih, Wolter, Katharina, Kang, Tae-Won, Schmacke, Niklas Arndt, Bridgeman, Anne, Rehwinkel, Jan, Zender, Lars, Ablasser, Andrea

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Exploiting lipotoxicity for the treatment of liver cancer von Rudalska, Ramona, Zender, Lars, Dauch, Daniel

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Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer von Hinterleitner, Clemens, Strähle, Jasmin, Malenke, Elke, Hinterleitner, Martina, Henning, Melanie, Seehawer, Marco, Bilich, Tatjana, Heitmann, Jonas, Lutz, Martina, Mattern, Sven, Scheuermann, Sophia, Horger, Marius, Maurer, Stefanie, Walz, Juliane, Fend, Falko, Handgretinger, Rupert, Seitz, Christian, Weigelin, Bettina, Singer, Stephan, Salih, Helmut, Borst, Oliver, Kopp, Hans-Georg, Zender, Lars

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The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration von Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P, Sansom, Owen J, Zender, Lars, Keyes, William M

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Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression von Eggert, Tobias, Wolter, Katharina, Ji, Juling, Ma, Chi, Yevsa, Tetyana, Klotz, Sabrina, Medina-Echeverz, José, Longerich, Thomas, Forgues, Marshonna, Reisinger, Florian, Heikenwalder, Mathias, Wang, Xin Wei, Zender, Lars, Greten, Tim F.

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Therapy-induced senescence — an induced synthetic lethality in liver cancer? von Wolter, Katharina, Zender, Lars

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Necroptosis microenvironment directs lineage commitment in liver cancer von Seehawer, Marco, Heinzmann, Florian, D’Artista, Luana, Harbig, Jule, Roux, Pierre-François, Hoenicke, Lisa, Dang, Hien, Klotz, Sabrina, Robinson, Lucas, Doré, Grégory, Rozenblum, Nir, Kang, Tae-Won, Chawla, Rishabh, Buch, Thorsten, Vucur, Mihael, Roth, Mareike, Zuber, Johannes, Luedde, Tom, Sipos, Bence, Longerich, Thomas, Heikenwälder, Mathias, Wang, Xin Wei, Bischof, Oliver, Zender, Lars

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NOTCH1 mediates a switch between two distinct secretomes during senescence von Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi

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CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo von Reautschnig, Philipp, Wahn, Nicolai, Wettengel, Jacqueline, Schulz, Annika E., Latifi, Ngadhnjim, Vogel, Paul, Kang, Tae-Won, Pfeiffer, Laura S., Zarges, Christine, Naumann, Ulrike, Zender, Lars, Li, Jin Billy, Stafforst, Thorsten

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Senescence of Activated Stellate Cells Limits Liver Fibrosis von Krizhanovsky, Valery, Yon, Monica, Dickins, Ross A., Hearn, Stephen, Simon, Janelle, Miething, Cornelius, Yee, Herman, Zender, Lars, Lowe, Scott W.

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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells von Georgilis, Athena, Klotz, Sabrina, Hanley, Christopher J., Herranz, Nicolas, Weirich, Benedikt, Morancho, Beatriz, Leote, Ana Carolina, D'Artista, Luana, Gallage, Suchira, Seehawer, Marco, Carroll, Thomas, Dharmalingam, Gopuraja, Wee, Keng Boon, Mellone, Marco, Pombo, Joaquim, Heide, Danijela, Guccione, Ernesto, Arribas, Joaquín, Barbosa-Morais, Nuno L., Heikenwalder, Mathias, Thomas, Gareth J., Zender, Lars, Gil, Jesús

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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype von Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J., Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J., Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A., Withers, Dominic, Zender, Lars, Thomas, Gareth J., Gil, Jesús

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence von Acosta, Juan Carlos, Banito, Ana, Wuestefeld, Torsten, Georgilis, Athena, Janich, Peggy, Morton, Jennifer P., Athineos, Dimitris, Kang, Tae-Won, Lasitschka, Felix, Andrulis, Mindaugas, Pascual, Gloria, Morris, Kelly J., Khan, Sadaf, Jin, Hong, Dharmalingam, Gopuraja, Snijders, Ambrosius P., Carroll, Thomas, Capper, David, Pritchard, Catrin, Inman, Gareth J., Longerich, Thomas, Sansom, Owen J., Benitah, Salvador Aznar, Zender, Lars, Gil, Jesús

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Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice von Moya, Iván M., Castaldo, Stéphanie A., Van den Mooter, Laura, Soheily, Soheil, Sansores-Garcia, Leticia, Jacobs, Jelle, Mannaerts, Inge, Xie, Jun, Verboven, Elisabeth, Hillen, Hanne, Algueró-Nadal, Ana, Karaman, Ruchan, Van Haele, Matthias, Kowalczyk, Weronika, De Waegeneer, Maxime, Verhulst, Stefaan, Karras, Panagiotis, van Huffel, Leen, Zender, Lars, Marine, Jean-Christophe, Roskams, Tania, Johnson, Randy, Aerts, Stein, van Grunsven, Leo A., Halder, Georg

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A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas von Zender, Steffen, Nickeleit, Irina, Wuestefeld, Torsten, Sörensen, Inga, Dauch, Daniel, Bozko, Przemyslaw, El-Khatib, Mona, Geffers, Robert, Bektas, Hueseyin, Manns, Michael P., Gossler, Achim, Wilkens, Ludwig, Plentz, Ruben, Zender, Lars, Malek, Nisar P.

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Nucleoporin Nup155 is part of the p53 network in liver cancer von Holzer, Kerstin, Ori, Alessandro, Cooke, Amy, Dauch, Daniel, Drucker, Elisabeth, Riemenschneider, Philip, Andres-Pons, Amparo, DiGuilio, Amanda L., Mackmull, Marie-Therese, Baßler, Jochen, Roessler, Stephanie, Breuhahn, Kai, Zender, Lars, Glavy, Joseph S., Dombrowski, Frank, Hurt, Ed, Schirmacher, Peter, Beck, Martin, Singer, Stephan

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Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours von Brenner, Ellen, Schörg, Barbara F., Ahmetlić, Fatima, Wieder, Thomas, Hilke, Franz Joachim, Simon, Nadine, Schroeder, Christopher, Demidov, German, Riedel, Tanja, Fehrenbacher, Birgit, Schaller, Martin, Forschner, Andrea, Eigentler, Thomas, Niessner, Heike, Sinnberg, Tobias, Böhm, Katharina S., Hömberg, Nadine, Braumüller, Heidi, Dauch, Daniel, Zwirner, Stefan, Zender, Lars, Sonanini, Dominik, Geishauser, Albert, Bauer, Jürgen, Eichner, Martin, Jarick, Katja J., Beilhack, Andreas, Biskup, Saskia, Döcker, Dennis, Schadendorf, Dirk, Quintanilla-Martinez, Leticia, Pichler, Bernd J., Kneilling, Manfred, Mocikat, Ralph, Röcken, Martin

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IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models von Martinez-Quetglas, Iris, Pinyol, Roser, Dauch, Daniel, Torrecilla, Sara, Tovar, Victoria, Moeini, Agrin, Alsinet, Clara, Portela, Anna, Rodriguez-Carunchio, Leonardo, Solé, Manel, Lujambio, Amaia, Villanueva, Augusto, Thung, Swan, Esteller, Manel, Zender, Lars, Llovet, Josep M

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