Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse von Hubmann, Max, Köhnke, Thomas, Hoster, Eva, Schneider, Stephanie, Dufour, Annika, Zellmeier, Evelyn, Fiegl, Michael, Braess, Jan, Bohlander, Stefan K, Subklewe, Marion, Sauerland, Maria-Cristina, Berdel, Wolfgang E, Büchner, Thomas, Wörmann, Bernhard, Hiddemann, Wolfgang, Spiekermann, Karsten

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Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia von Rothenberg-Thurley, M, Amler, S, Goerlich, D, Köhnke, T, Konstandin, N P, Schneider, S, Sauerland, M C, Herold, T, Hubmann, M, Ksienzyk, B, Zellmeier, E, Bohlander, S K, Subklewe, M, Faldum, A, Hiddemann, W, Braess, J, Spiekermann, K, Metzeler, K H

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Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia von Metzeler, Klaus H., Herold, Tobias, Rothenberg-Thurley, Maja, Amler, Susanne, Sauerland, Maria C., Görlich, Dennis, Schneider, Stephanie, Konstandin, Nikola P., Dufour, Annika, Bräundl, Kathrin, Ksienzyk, Bianka, Zellmeier, Evelyn, Hartmann, Luise, Greif, Philipp A., Fiegl, Michael, Subklewe, Marion, Bohlander, Stefan K., Krug, Utz, Faldum, Andreas, Berdel, Wolfgang E., Wörmann, Bernhard, Büchner, Thomas, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten

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Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients von Greif, Philipp A, Hartmann, Luise, Vosberg, Sebastian, Stief, Sophie M, Mattes, Raphael, Hellmann, Ines, Metzeler, Klaus H, Herold, Tobias, Bamopoulos, Stefanos A, Kerbs, Paul, Jurinovic, Vindi, Schumacher, Daniela, Pastore, Friederike, Bräundl, Kathrin, Zellmeier, Evelyn, Ksienzyk, Bianka, Konstandin, Nikola P, Schneider, Stephanie, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Neumann, Martin, Baldus, Claudia D, Bohlander, Stefan K, Wolf, Stephan, Görlich, Dennis, Berdel, Wolfgang E, Wörmann, Bernhard J, Hiddemann, Wolfgang, Spiekermann, Karsten

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Acute Myeloid Leukemia With Biallelic CEBPA Gene Mutations and Normal Karyotype Represents a Distinct Genetic Entity Associated With a Favorable Clinical Outcome von DUFOUR, Annika, SCHNEIDER, Friederike, WÖRMANN, Bernhard, BRAESS, Jan, HIDDEMANN, Wolfgang, BOHLANDER, Stefan K, SPIEKERMANN, Karsten, METZELER, Klaus H, HOSTER, Eva, SCHNEIDER, Stephanie, ZELLMEIER, Evelyn, BENTHAUS, Tobias, SAUERLAND, Maria-Cristina, BERDEL, Wolfgang E, BÜCHNER, Thomas

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Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia von Pastore, Friederike, Dufour, Annika, Benthaus, Tobias, Metzeler, Klaus H, Maharry, Kati S, Schneider, Stephanie, Ksienzyk, Bianka, Mellert, Gudrun, Zellmeier, Evelyn, Kakadia, Purvi M, Unterhalt, Michael, Feuring-Buske, Michaela, Buske, Christian, Braess, Jan, Sauerland, Maria Cristina, Heinecke, Achim, Krug, Utz, Berdel, Wolfgang E, Buechner, Thomas, Woermann, Bernhard, Hiddemann, Wolfgang, Bohlander, Stefan K, Marcucci, Guido, Spiekermann, Karsten, Bloomfield, Clara D, Hoster, Eva

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ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation von Hartmann, Luise, Dutta, Sayantanee, Opatz, Sabrina, Vosberg, Sebastian, Reiter, Katrin, Leubolt, Georg, Metzeler, Klaus H., Herold, Tobias, Bamopoulos, Stefanos A., Bräundl, Kathrin, Zellmeier, Evelyn, Ksienzyk, Bianka, Konstandin, Nikola P., Schneider, Stephanie, Hopfner, Karl-Peter, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Middeke, Jan Moritz, Stölzel, Friedrich, Thiede, Christian, Wolf, Stephan, Bohlander, Stefan K., Preiss, Caroline, Chen-Wichmann, Linping, Wichmann, Christian, Sauerland, Maria Cristina, Büchner, Thomas, Berdel, Wolfgang E., Wörmann, Bernhard J., Braess, Jan, Hiddemann, Wolfgang, Spiekermann, Karsten, Greif, Philipp A.

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The NPM1 mutation type has no impact on survival in cytogenetically normal AML von Pastore, Friederike, Greif, Philipp A, Schneider, Stephanie, Ksienzyk, Bianka, Mellert, Gudrun, Zellmeier, Evelyn, Braess, Jan, Sauerland, Cristina M, Heinecke, Achim, Krug, Utz, Berdel, Wolfgang E, Buechner, Thomas, Woermann, Bernhard, Hiddemann, Wolfgang, Spiekermann, Karsten

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Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia von Opatz, Sabrina, Polzer, Harald, Herold, Tobias, Konstandin, Nikola P., Ksienzyk, Bianka, Zellmeier, Evelyn, Vosberg, Sebastian, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Hopfner, Karl-Peter, Kakadia, Purvi M., Schneider, Stephanie, Dufour, Annika, Braess, Jan, Sauerland, Maria Cristina, Berdel, Wolfgang E., Büchner, Thomas, Woermann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K., Greif, Philipp A.

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GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia von Greif, Philipp A., Dufour, Annika, Konstandin, Nikola P., Ksienzyk, Bianka, Zellmeier, Evelyn, Tizazu, Belay, Sturm, Jutta, Benthaus, Tobias, Herold, Tobias, Yaghmaie, Marjan, Dörge, Petra, Hopfner, Karl-Peter, Hauser, Andreas, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Kakadia, Purvi M., Schneider, Stephanie, Hoster, Eva, Schneider, Friederike, Stanulla, Martin, Braess, Jan, Sauerland, Maria Cristina, Berdel, Wolfgang E., Büchner, Thomas, Woermann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K.

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Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis von Herold, Tobias, Metzeler, Klaus H., Vosberg, Sebastian, Hartmann, Luise, Röllig, Christoph, Stölzel, Friedrich, Schneider, Stephanie, Hubmann, Max, Zellmeier, Evelyn, Ksienzyk, Bianka, Jurinovic, Vindi, Pasalic, Zlatana, Kakadia, Purvi M., Dufour, Annika, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Sauerland, Maria Cristina, Büchner, Thomas, Berdel, Wolfgang E., Woermann, Bernhard J., Bornhäuser, Martin, Ehninger, Gerhard, Mansmann, Ulrich, Hiddemann, Wolfgang, Bohlander, Stefan K., Spiekermann, Karsten, Greif, Philipp A.

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Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4 von Herold, Tobias, Metzeler, Klaus H., Vosberg, Sebastian, Hartmann, Luise, Jurinovic, Vindi, Opatz, Sabrina, Konstandin, Nikola P., Schneider, Stephanie, Zellmeier, Evelyn, Ksienzyk, Bianka, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Cristina Sauerland, Maria, Büchner, Thomas, Berdel, Wolfgang E., Wörmann, Bernhard J., Mansmann, Ulrich, Hiddemann, Wolfgang, Bohlander, Stefan K., Spiekermann, Karsten, Greif, Philipp A.

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Comparison of FLT3-ITD Detection By High-Throughput Amplicon Sequencing to Routine Diagnostics - a Retrospective Analysis of AMLCG Study Patients von Reiter, Katrin, Hubmann, Max, Harin, Egor, Vosberg, Sebastian, Bräundl, Kathrin, Ksienzyk, Bianka, Schneider, Stephanie, Dufour, Annika Maria, Zellmeier, Evelyn, Bohlander, Stefan K., Sauerland, Christina, Berdel, Wolfgang E, Wörmann, Bernhard J, Büchner, Thomas, Braess, Jan, Hiddemann, Wolfgang, Spiekermann, Karsten, Greif, Philipp A.

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The FLT3ITD mRNA level has a high prognostic impact in NPM1 mutated, but not in NPM1 unmutated, AML with a normal karyotype von Schneider, Friederike, Hoster, Eva, Unterhalt, Michael, Schneider, Stephanie, Dufour, Annika, Benthaus, Tobias, Mellert, Gudrun, Zellmeier, Evelyn, Kakadia, Purvi M., Bohlander, Stefan K., Feuring-Buske, Michaela, Buske, Christian, Braess, Jan, Heinecke, Achim, Sauerland, Maria C., Berdel, Wolfgang E., Büchner, Thomas, Wörmann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten

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NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS) von Schneider, Friederike, Hoster, Eva, Unterhalt, Michael, Schneider, Stephanie, Dufour, Annika, Benthaus, Tobias, Mellert, Gudrun, Zellmeier, Evelin, Bohlander, Stefan K., Feuring-Buske, Michaela, Buske, Christian, Braess, Jan, Fritsch, Susanne, Heinecke, Achim, Sauerland, Maria C., Berdel, Wolfgang E., Buechner, Thomas, Woermann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten

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DNMT3A Mutations Associate with Shorter Survival and Modulate the Prognostic Impact of Mutated NPM1: an Analysis Based on Comprehensive Mutational Screening of 660 AML Patients Tre... von Metzeler, Klaus H., Herold, Tobias, Rothenberg-Thurley, Maja, Amler, Susanne, Sauerland, Cristina, Schneider, Stephanie, Konstandin, Nikola P, Dufour, Annika Maria, Bräundl, Kathrin, Ksienzyk, Bianka, Zellmeier, Evelyn, Hartmann, Luise, Greif, Philipp A., Fiegl, Michael, Subklewe, Marion S., Bohlander, Stefan K., Krug, Utz, Berdel, Wolfgang E, Wörmann, Bernhard, Büchner, Thomas, Faldum, Andreas, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten

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A Combined Molecular and Clinical Prognostic Index For Relapse and Survival In Cytogenetically Normal AML (PINA) von Pastore, Friederike, Dufour, Annika, Benthaus, Tobias, Metzeler, Klaus H., Maharry, Kati, Schneider, Stephanie, Ksienzyk, Bianka, Mellert, Gudrun, Zellmeier, Evelyn, Kakadia, Purvi M., Unterhalt, Michael, Feuring-Buske, Michaela, Buske, Christian, Braess, Jan, Sauerland, Cristina, Heinecke, Achim, Krug, Utz, Berdel, Wolfgang E., Büchner, Thomas, Woermann, Bernhard J., Hiddemann, Wolfgang, Bohlander, Stefan K., Marcucci, Guido, Spiekermann, Karsten, Bloomfield, Clara D., Hoster, Eva

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Acute Myeloid Leukemia With Isolated Trisomy 13 Is a Genetically Homogenous Entity With a High Frequency Of Mutations In Genes Encoding Components Of The Splicing Machinery and Ext... von Herold, Tobias, Metzeler, Klaus H., Vosberg, Sebastian, Schneider, Stephanie, Hubmann, Max, Zellmeier, Evelyn, Ksienzyk, Bianka, Jurinovic, Vindi, Pasalic, Zlatana, Kakadia, Purvi M., Dufour, Annika, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Sauerland, Cristina, Büchner, Thomas, Berdel, Wolfgang E., Woermann, Bernhard J., Mansmann, Ulrich, Hiddemann, Wolfgang, Bohlander, Stefan K., Spiekermann, Karsten, Greif, Philipp A

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High Frequency of GATA2 Mutations in Cytogenetically Normal Acute Myeloid Leukemia with Biallelic CEBPA Mutations Identified by Exome Sequencing von Dufour, Annika, Konstandin, Nikola, Ksienzyk, Bianka, Zellmeier, Evelyn, Benthaus, Tobias, Yaghmaie, Marjan, Graf, Alexander, Krebs, Stefan, Hauser, Andreas, Blum, Helmut, Kakadia, Purvi, Schneider, Stephanie, Braess, Jan, Woermann, Bernhard Josef, Berdel, Wolfgang E, Büchner, Thomas, Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K, Greif, Philipp A

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DE3513171 von ZELLMEIER, GUENTHER, 8400 REGENSBURG, DE, SCHINDLER, JOSEF, REITER, ALOIS, 8000 MUENCHEN, DE

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