Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA von Coelho, Matthew A., de Carné Trécesson, Sophie, Rana, Sareena, Zecchin, Davide, Moore, Christopher, Molina-Arcas, Miriam, East, Philip, Spencer-Dene, Bradley, Nye, Emma, Barnouin, Karin, Snijders, Ambrosius P., Lai, Wi S., Blackshear, Perry J., Downward, Julian

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR von Prahallad, Anirudh, Sun, Chong, Huang, Sidong, Di Nicolantonio, Federica, Salazar, Ramon, Zecchin, Davide, Beijersbergen, Roderick L., Bardelli, Alberto, Bernards, René

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Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer von Bardelli, Alberto, Corso, Simona, Bertotti, Andrea, Hobor, Sebastijan, Valtorta, Emanuele, Siravegna, Giulia, Sartore-Bianchi, Andrea, Scala, Elisa, Cassingena, Andrea, Zecchin, Davide, Apicella, Maria, Migliardi, Giorgia, Galimi, Francesco, Lauricella, Calogero, Zanon, Carlo, Perera, Timothy, Veronese, Silvio, Corti, Giorgio, Amatu, Alessio, Gambacorta, Marcello, Diaz, Jr, Luis A, Sausen, Mark, Velculescu, Victor E, Comoglio, Paolo, Trusolino, Livio, Di Nicolantonio, Federica, Giordano, Silvia, Siena, Salvatore

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Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer von Zecchin, Davide, Moore, Christopher, Michailidis, Fanourios, Horswell, Stuart, Rana, Sareena, Howell, Michael, Downward, Julian

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Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3 von Sun, Chong, Hobor, Sebastijan, Bertotti, Andrea, Zecchin, Davide, Huang, Sidong, Galimi, Francesco, Cottino, Francesca, Prahallad, Anirudh, Grernrum, Wipawadee, Tzani, Anna, Schlicker, Andreas, Wessels, Lodewyk F A, Smit, Egbert F, Thunnissen, Erik, Halonen, Pasi, Lieftink, Cor, Beijersbergen, Roderick L, Di Nicolantonio, Federica, Bardelli, Alberto, Trusolino, Livio, Bernards, Rene

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Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses von Di Nicolantonio, Federica, Arena, Sabrina, Gallicchio, Margherita, Zecchin, Davide, Martini, Miriam, Flonta, Simona Emilia, Stella, Giulia Maria, Lamba, Simona, Cancelliere, Carlotta, Russo, Mariangela, Geuna, Massimo, Appendino, Giovanni, Fantozzi, Roberto, Medico, Enzo, Bardelli, Alberto

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The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase von Olivero, Martina, Dettori, Daniela, Arena, Sabrina, Zecchin, Davide, Lantelme, Erica, Di Renzo, Maria Flavia

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers von Houlihan, Catherine F, Kelly, Gavin, Spyer, Moira J, Nastouli, Eleni, Allen, Zoe, Ambrose, Karen, Barns-Jenkins, Caitlin, Basu, Souradeep, Buck, Michael D, Cardoso, Ana, Carter, Nick, Carvalho, Luiz, Chen, Qu, Churchward, Laura, Cottrell, Sally, Davison, Dara, Debaisieux, Solene, Diaz-Romero, Monica, Diring, Jessica, Driscoll, Paul C, Edwards, Amelia, Evangelopoulos, Dimitrios, Ferron, Aaron, Fitz, Dan, Fleming, James, Gaiba, Alessandra, Goldstone, Robert, Halldorsson, Steinar, Hoskins, Beth, Houlihan, Catherine F, Hoyle, Jacqueline, Htun, Mint R, Hubank, Michael, Hughes, Deborah, Instrell, Rachael, Jamal-Hanjani, Mariam, Johnson, Mark, Kotzampaltiris, Paul, Kousis, Konstantinos, Kucharska, Ania, Lee, Stacey-Ann, Lu, Wei-Ting, MacRae, James I, McCoy, Laura E, Minutti, Carlos M, Molina-Arcas, Miriam, Moore, David, Moraiti, Anastasia, Nutan, Savita, Oedekoven, Caroline, O'Neill, Olga, Osborne, Neil, Papayannopoulos, Venizelos, Patel, Yogen, Paun, Oana, Perez Caballero, Ana, Perez-Lloret, Jimena, Pollitt, Marc, Shah Punatar, Rajvee, Ramaprasad, Abhinay, Richardson, Kayleigh, Ridewood, Sophie, Rossi, Alice, Rowan, Andrew, Sahai, Erik, Sawyer, Chelsea, Spyer, Moira J, Steel, Louisa, Strange, Amy, Swanton, Charles, Tautz-Davis, Zoe H, Taylor, Gunes, Toolan-Kerr, Patrick, Torelli, Francesca, Toteva, Tea, Ule, Jernej, Wenman, Catharina, Williams, Matthew J, Wright, Joshua, Xiang, Zheng, Matthews, Rebecca, Severn, Abigail, Michie, Susan, Shahmanesh, Maryam, Lukha, Hinal, Davies, Claudia, Williams, Bethany, Riddell, Andrew, Bartolovic, Kerol, Russell, Emma, Carr, Lotte, Crayton, Elise, Meyer, Carly, Vora, Nina, Stoltenberg, Andrea, Byrne, Tom, Gilson, Richard, Kelly, Gavin, Roberts, Fiona, Hatipoglu, Emine

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Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma von Sun, Chong, Wang, Liqin, Huang, Sidong, Heynen, Guus J. J. E., Prahallad, Anirudh, Robert, Caroline, Haanen, John, Blank, Christian, Wesseling, Jelle, Willems, Stefan M., Zecchin, Davide, Hobor, Sebastijan, Bajpe, Prashanth K., Lieftink, Cor, Mateus, Christina, Vagner, Stephan, Grernrum, Wipawadee, Hofland, Ingrid, Schlicker, Andreas, Wessels, Lodewyk F. A., Beijersbergen, Roderick L., Bardelli, Alberto, Di Nicolantonio, Federica, Eggermont, Alexander M. M., Bernards, Rene

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Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus von Di Nicolantonio, Federica, Arena, Sabrina, Tabernero, Josep, Grosso, Stefano, Molinari, Francesca, Macarulla, Teresa, Russo, Mariangela, Cancelliere, Carlotta, Zecchin, Davide, Mazzucchelli, Luca, Sasazuki, Takehiko, Shirasawa, Senji, Geuna, Massimo, Frattini, Milo, Baselga, José, Gallicchio, Margherita, Biffo, Stefano, Bardelli, Alberto

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O09 Targeted genetic therapy for congenital melanocytic naevi von Bryant, Dale, Barberan-Martin, Sara, Maeshima, Ruhina, Del Valle Torres, Ignacio, Rabii, Mohammad, Sauvadet, Aimie, Demetriou, Charalambos, Knöpfel, Nicole, Michailides, Fanis, Riachi, Melissa, Zecchin, Davide, Pittman, Alan, Polubothu, Satyamaanasa, Hart, Steve, Kinsler, Veronica

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GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics von Zecchin, Davide, Knöpfel, Nicole, Gluck, Anna K., Stevenson, Mark, Sauvadet, Aimie, Polubothu, Satyamaanasa, Barberan-Martin, Sara, Michailidis, Fanourios, Bryant, Dale, Inoue, Asuka, Lines, Kate E., Hannan, Fadil M., Semple, Robert K., Thakker, Rajesh V., Kinsler, Veronica A.

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RNA Therapy for Oncogenic NRAS-Driven Nevi Induces Apoptosis von Bryant, Dale, Barberan-Martin, Sara, Maeshima, Ruhina, del Valle Torres, Ignacio, Rabii, Mohammad, Baird, William, Sauvadet, Aimie, Demetriou, Charalambos, Jones, Phoebe, Knöpfel, Nicole, Michailidis, Fanourios, Riachi, Melissa, Bennett, Dorothy C., Zecchin, Davide, Pittman, Alan, Polubothu, Satyamaanasa, Hart, Stephen, Kinsler, Veronica A.

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Mosaic BRAF Fusions Are a Recurrent Cause of Congenital Melanocytic Nevi Targetable by MAPK Pathway Inhibition von Martin, Sara Barberan, Polubothu, Satyamaanasa, Bruzos, Alicia Lopez, Kelly, Gavin, Horswell, Stuart, Sauvadet, Aimie, Bryant, Dale, Zecchin, Davide, Riachi, Melissa, Michailidis, Fanourios, Sadri, Amir, Muwanga-Nanyonjo, Noreen, Lopez-Balboa, Pablo, Knöpfel, Nicole, Bulstrode, Neil, Pittman, Alan, Yeh, Iwei, Kinsler, Veronica A.

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Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI 3K pathway inhibitors in PTEN ‐null triple negative breast cancer von Zecchin, Davide, Moore, Christopher, Michailidis, Fanourios, Horswell, Stuart, Rana, Sareena, Howell, Michael, Downward, Julian

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GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification von Knöpfel, Nicole, Zecchin, Davide, Richardson, Hanna, Polubothu, Satyamaanasa, Barberan-Martin, Sara, Cullup, Thomas, Gholam, Karolina, Heales, Simon, Krywawych, Steve, López-Balboa, Pablo, Muwanga-Nanyonjo, Noreen, Ogunbiyi, Olumide, Puvirajasinghe, Clinda, Solman, Lea, Swarbrick, Katherine, Syed, Samira B., Tahir, Zubair, Tisdall, Martin M., Allgrove, Jeremy, Chesover, Alexander D., Aylett, Sarah E., Jacques, Thomas S., Hannan, Fadil M., Löbel, Ulrike, Semple, Robert K., Thakker, Rajesh V., Kinsler, Veronica A.

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PTPN11 Mosaicism Causes a Spectrum of Pigmentary and Vascular Neurocutaneous Disorders and Predisposes to Melanoma von Polubothu, Satyamaanasa, Bender, Nicole, Muthiah, Siobhan, Zecchin, Davide, Demetriou, Charalambos, Martin, Sara Barberan, Malhotra, Sony, Travnickova, Jana, Zeng, Zhiqiang, Böhm, Markus, Barbarot, Sebastien, Cottrell, Catherine, Davies, Olivia, Baselga, Eulalia, Burrows, Nigel P., Carmignac, Virginie, Diaz, Joey Santiago, Fink, Christine, Haenssle, Holger A., Happle, Rudolf, Harland, Mark, Majerowski, Jacquelyn, Vabres, Pierre, Vincent, Marie, Newton-Bishop, Julia A., Bishop, D. Tim, Siegel, Dawn, Patton, E. Elizabeth, Topf, Maya, Rajan, Neil, Drolet, Beth, Kinsler, Veronica A.

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Tracking the genomic evolution of breast cancer metastasis von Zecchin, Davide, Bardelli, Alberto

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Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy von Balestrini, Simona, Anders-Cannon, Jonny, Silvennoinen, Katri, Zagaglia, Sara, Pardington, Rosemarie, Ambrose, Karen, Avola, Alida, Barr, Genevieve, Bineva-Todd, Ganka, Bonnet, Dominique, Buck, Michael D., Busby, Louise, Byott, Matthew, Caidan, Simon, Carvalho, Luiz, Chandler, Natalie, Clayton, Bobbi, Collins, Zena, Cullup, Tom, Davies, Heledd, Davis, Patrick, Diaz-Romero, Monica, D'Avola, Annalisa, Edwards, Amelia, Faraway, Rupert, Fleming, James, Frederico, Bruno, Gaul, Liam, Goldman, Jacki, Goldstone, Robert, Grant, Paul R., Guedan, Anabel, Hall, Ross, Harris, Suzanne, Heaney, Judith, Hirani, Rajnika, Hope, Joshua, Howell, Michael, Howitt, Louise, Htun, Mint R., Hughes, Jane, Jenkins, Lucy, Kanu, Nnennaya, Kjaer, Svend, Knuepfer, Ellen, Lappin, Michelle, Marczak, Julie A., Martensson, Mimmi, Matthews, John, McCall, Samuel, Minutti, Carlos M., Montaner, Beatriz, Moore, Catherine, Moreira-Teixeira, Lucia, Naceur-Lombardelli, Cristina, Nelson, Aileen, Nicod, Jerome, Nightingale, Luke, Nofal, Stephanie, O'Reilly, Nicola, Patel, Namita, Patel, Yogen, Caballero, Ana Perez, Perrault, Magali S., Prieto-Godino, Lucia, Proust, Alize, Puvirajasinghe, Clinda, Queval, Christophe, Roberts, Fiona, Rodgers, Angela, Romero Clavijo, Pablo, Roustan, Chloe, Rowan, Andrew, Sait, Aaron, Sala, Katarzyna, Sanchez, Emilie, Santucci, Pierre, Sardar, Fatima, Shahmanesh, Maryam, Spyer, Moira J., Steel, Louisa, Sullivan, Adrienne E., Tautz-Davis, Zoe H., Taylor, Gunes, Taylor, Harriet B., Torelli, Francesca, Treeck, Moritz, Tsai, Ming-Han C., Venkatesan, Subramanian, Wang, Yiran, Wenman, Catharina, Williams, Luke, Williams, Matthew J., Zecchin, Davide, Zillwood, Rachel, Sisodiya, Sanjay M., Norris, Sarah, Rugg-Gunn, Fergus, Shaya, Gabriel, Singh, Priyanka

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Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype von Polubothu, Satyamaanasa, Zecchin, Davide, Al-Olabi, Lara, Lionarons, Daniël A., Harland, Mark, Horswell, Stuart, Thomas, Anna C., Hunt, Lilian, Wlodarchak, Nathan, Aguilera, Paula, Brand, Sarah, Bryant, Dale, Carrera, Cristina, Chen, Hui, Elgar, Greg, Harwood, Catherine A., Howell, Michael, Larue, Lionel, Loughlin, Sam, MacDonald, Jeff, Malvehy, Josep, Barberan, Sara Martin, da Silva, Vanessa Martins, Molina, Miriam, Morrogh, Deborah, Moulding, Dale, Nsengimana, Jérémie, Pittman, Alan, Puig-Butillé, Joan-Anton, Parmar, Kiran, Sebire, Neil J., Scherer, Stephen, Stadnik, Paulina, Stanier, Philip, Tell, Gemma, Waelchli, Regula, Zarrei, Mehdi, Puig, Susana, Bataille, Véronique, Xing, Yongna, Healy, Eugene, Moore, Gudrun E., Di, Wei-Li, Newton-Bishop, Julia, Downward, Julian, Kinsler, Veronica A.

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