P5327Are we being able to meet current guidelines LDL-cholesterol goals in very high risk patients? How many of them could benefit of PSCK9 inhibition by the FOURIER/ODYSSEY and NI... von El Andere, T, Soto, J A T, Moreira, I S, Wamser, M N, Freitas, H C, Almeida, M P C, Goncalves, R M, Zatz, H P, Araujo, D B, Sulzbach, M L, Bertolami, A, Faludi, A A

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L 029 First Degree Marriages in a Hypercholesterolemic Family von Bertolami, A, Faludi, AA, Araújo, DB, Zatz, HP, Nakamura, Y, Bertolami, MC

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L 019 Hydric Ingestion and the Risk of Dehydratation in a Population of Medical Residents in a Cardiologic Hospital von Amparo, FC, Kovacs, C, Santos, MCR, Magnoni, CD, Moreira, P, Bertolami, A, Faludi, AP, Araújo, DB, Zatz, HP, Bertolami, MC

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L 031 Obtaining the Prevention Goals for Cardiovascular Disease Following the Brazilian Society of Cardiology Guidelines von Moreira, HG, Junior, WG, Neto, SA, Nunes, GJ, Trindade, PHDM, Faludi, AA, Araújo, DB, Bertolami, A, Zatz, HP, Bertolami, MC

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D 015 Glucose Tolerance Test – Important on the Assessment of the Glicidic Metabolism in Obese Patients with Low HDL Cholesterol von Faludi, EP, Faludi, AA, Bertolami, A, Araújo, DB, Tome, ACN, Zatz, HP, Atanazio, MJ, Nakamura, Y, Bertolami, MC

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L 030 Abdominal Circumference – Which Criterion to Use in the Clinical Practice von Faludi, EP, Araújo, DB, Zatz, HP, Bertolami, A, Faludi, AA, Tome, ACN, Atanazio, MJ, Nakamura, Y, Bertolami, MC

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L 023 The Success of Cholesterol-lowering Treatment goes Beyond Pharmacological Therapy von Ibañez, TLP, Capeletti, JT, Barbosa, RR, Cestari, PF, Peres, GMTLSR, Bertolami, A, Faludi, AA, Araújo, DB, Zatz, HP, Bertolami, MC

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A 030 Hypothireoidism and Metabolic Syndrome von Faludi, EP, Faludi, AA, Bertolami, A, Araújo, DB, Zatz, HP, Tome, ACN, Atanazio, MJ, Nakamura, Y, Bertolami, MC

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L 004 Inter Observer Variation in the Analyses of the Abdominal Circumference von Calvilho, AA, Rinaldi, FS, Montano, ZT, Motta, LGM, Bertolami, A, Faludi, AA, Araújo, DB, Zatz, HP, Bertolami, MC, Amparo, FC

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Zika Virus Selectively Kills Aggressive Human Embryonal CNS Tumor Cells In Vitro and In Vivo von Kaid, Carolini, Goulart, Ernesto, Caires-Júnior, Luiz C, Araujo, Bruno H S, Soares-Schanoski, Alessandra, Bueno, Heloisa M S, Telles-Silva, Kayque A, Astray, Renato M, Assoni, Amanda F, Júnior, Antônio F R, Ventini, Daniella C, Puglia, Ana L P, Gomes, Roselane P, Zatz, Mayana, Okamoto, Oswaldo K

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Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis von Figueiredo, Thalita, Mendes, Ana P. D., Moreira, Danielle P., Goulart, Ernesto, Oliveira, Danyllo, Kobayashi, Gerson S., Stern, Shani, Kok, Fernando, Marchetto, Maria C., Santos, Renata, Gage, Fred H., Zatz, Mayana

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Genetically modified ZIKA virus as a microRNA-sensitive oncolytic virus against central nervous system tumors von Novaes, Gabriela Machado, Lima, Caroline, Longo, Carla, Machado, Pedro Henrique, Silva, Thais Peron, Olberg, Giovanna Gonçalves de Oliveira, Módolo, Diego Grando, Pereira, Márcia Cristina Leite, Santos, Tiago Goss, Zatz, Mayana, Lagares, David, de Franco, Marcelo, Ho, Paulo Lee, Bulstrode, Harry, Okamoto, Oswaldo Keith, Kaid, Carolini

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Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types von Chaurasia, S. S., Rollag, M. D., Jiang, G., Hayes, W. P., Haque, R., Natesan, A., Zatz, M., Tosini, G., Liu, C., Korf, H. W., Iuvone, P. M., Provencio, I.

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X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 von Asano, T, Boisson, B, Onodi, F, Matuozzo, D, Moncada-Velez, M, Renkilaraj, MRLM, Zhang, P, Meertens, L, Bolze, A, Materna, M, Korniotis, S, Gervais, A, Talouarn, E, Bigio, B, Bilguvar, K, Zhang, Y, Neehus, AL, Ogishi, M, Pelham, SJ, Le Voyer, T, Rosain, J, Philippot, Q, Soler-Palacin, P, Colobran, R, Riviere, JG, Tandjaoui-Lambiotte, Y, Chaibi, K, Shahrooei, M, Darazam, IA, Olyaei, NA, Mansouri, D, Palabiyik, F, Ozcelik, T, Novelli, G, Novelli, A, Casari, G, Aiuti, A, Carrera, P, Bondesan, S, Barzaghi, F, Rovere-Querini, P, Tresoldi, C, Rojas, J, Reyes, LF, Bustos, IG, Arias, AA, Morelle, G, Kyheng, C, Troya, J, Planas-Serra, L, Schluter, A, Gut, M, Pujol, A, Allende, LM, Rodriguez-Gallego, C, Cabrera-Marante, O, Pleguezuelo, DE, de Diego, RP, Keles, S, Aytekin, G, Akcan, OM, Bryceson, YT, Bergman, P, Brodin, P, Smole, D, Smith, CIE, Norlin, AC, Campbell, TM, Covill, LE, Hammarstrom, L, Pan-Hammarstrom, Q, Abolhassani, H, Mane, S, Marr, N, Ata, M, Al Ali, F, Khan, T, Spaan, AN, Bonfanti, P, Biondi, A, Tubiana, S, Burdet, C, Kahn-Kirby, A, Snow, AL, Bustamante, J, Puel, A, Boisson-Dupuis, S, Zhang, SY, Beziat, V, Lifton, RP, Bastard, P, Notarangelo, LD, Abel, L, Su, HC, Jouanguy, E, Amara, A, Soumelis, V, Cobat, A, Zhang, Q, Casanova, JL

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Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia von Zhang, Qian, Matuozzo, Daniela, Le Pen, Jérémie, Lee, Danyel, Moens, Leen, Asano, Takaki, Bohlen, Jonathan, Liu, Zhiyong, Moncada-Velez, Marcela, Kendir-Demirkol, Yasemin, Jing, Huie, Bizien, Lucy, Marchal, Astrid, Abolhassani, Hassan, Delafontaine, Selket, Bucciol, Giorgia, Bayhan, Gulsum Ical, Keles, Sevgi, Kiykim, Ayca, Hancerli, Selda, Haerynck, Filomeen, Florkin, Benoit, Hatipoglu, Nevin, Ozcelik, Tayfun, Morelle, Guillaume, Zatz, Mayana, Ng, Lisa F P, Lye, David Chien, Young, Barnaby Edward, Leo, Yee-Sin, Dalgard, Clifton L, Lifton, Richard P, Renia, Laurent, Meyts, Isabelle, Jouanguy, Emmanuelle, Hammarström, Lennart, Pan-Hammarström, Qiang, Boisson, Bertrand, Bastard, Paul, Su, Helen C, Boisson-Dupuis, Stéphanie, Abel, Laurent, Rice, Charles M, Zhang, Shen-Ying, Cobat, Aurélie, Casanova, Jean-Laurent

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Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency von Le Voyer, Tom, Parent, Audrey V., Liu, Xian, Cederholm, Axel, Gervais, Adrian, Rosain, Jérémie, Nguyen, Tina, Perez Lorenzo, Malena, Rinchai, Darawan, Zhang, Peng, Hancioglu, Gonca, Ghillani-Dalbin, Pascale, Charuel, Jean-Luc, Philippot, Quentin, Gueye, Mame Sokhna, Soudée, Camille, Rozenberg, Flore, Momenilandi, Mana, Riller, Quentin, Delmonte, Ottavia M., Müller, Gabriele, Keller, Baerbel, Orrego, Julio, Rubin, Tamar, Emiroglu, Melike, Eriksson, Daniel, Katelaris, Constance H., Mustillo, Peter, Raedler, Johannes, Bohlen, Jonathan, Bengi Celik, Jale, Astudillo, Camila, Winter, Sarah, Guffroy, Aurélien, DeRisi, Joseph L., Yu, David, Miller, Corey, Feng, Yi, Guichard, Audrey, Béziat, Vivien, Bustamante, Jacinta, Pan-Hammarström, Qiang, Rosen, Lindsey B., Bosticardo, Marita, Kenney, Heather, Castagnoli, Riccardo, Slade, Charlotte A., Boztuğ, Kaan, Latour, Sylvain, Sediva, Anna, Atschekzei, Faranaz, Sogkas, Georgios, Poli, M. Cecilia, Palterer, Boaz, Keller, Michael D., Pinzon-Charry, Alberto, Sullivan, Anna, Droney, Luke, Suan, Daniel, Wong, Melanie, Ma, Cindy, Dalal, Ilan, Hie, Miguel, Lazaro, Estibaliz, Franco, Jose, Malphettes, Marion, Pasquet, Marlene, Maccari, Maria Elena, Frosk, Patrick, Goodnow, Christopher C., Gray, Paul E., Belot, Alexandre, Kuehn, Hye Sun, Servettaz, Amélie, Barlogis, Vincent, Le Guenno, Guillaume, Herrmann, Vera-Maria, Kuijpers, Taco, Ducoux, Grégoire, Sarrot-Reynauld, Françoise, Schuetz, Catharina, Cunningham-Rundles, Charlotte, Rieux-Laucat, Frédéric, Tangye, Stuart G., Doffinger, Rainer, Grimbacher, Bodo, Berteloot, Laureline, Trouillet Assant, Sophie, Su, Helen, Abel, Laurent, Zhang, Qian, Boisson, Bertrand, Cobat, Aurélie, Jouanguy, Emmanuelle, Kampe, Olle, Bastard, Paul, Roifman, Chaim M., Notarangelo, Luigi D., Anderson, Mark S., Casanova, Jean-Laurent

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Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass ind... von Scliar, Marilia O., Sant’Anna, Hanaisa P., Santolalla, Meddly L., Leal, Thiago P., Araújo, Nathalia M., Alvim, Isabela, Borda, Victor, Magalhães, Wagner C. S., Gouveia, Mateus H., Lyra, Ricardo, Machado, Moara, Michelin, Lucas, Rodrigues, Maíra R., Araújo, Gilderlanio S., Kehdy, Fernanda S. G., Zolini, Camila, Peixoto, Sérgio V., Luizon, Marcelo R., Lobo, Francisco, Naslavsky, Michel S., Yamamoto, Guilherme L., Duarte, Yeda A. O., Hansen, Matthew E. B., Norris, Shane A., Gilman, Robert H., Guio, Heinner, Hsing, Ann W., Mbulaiteye, Sam M., Mensah, James, Dutil, Julie, Yeager, Meredith, Yeboah, Edward, Tishkoff, Sarah A., Choudhury, Ananyo, Ramsay, Michele, Passos-Bueno, Maria Rita, Zatz, Mayana, O´Connor, Timothy D., Pereira, Alexandre C., Barreto, Mauricio L., Lima-Costa, Maria Fernanda, Horta, Bernardo L., Tarazona-Santos, Eduardo

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A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability von Figueiredo, T, Melo, U S, Pessoa, A L S, Nobrega, P R, Kitajima, J P, Rusch, H, Vaz, F, Lucato, L T, Zatz, M, Kok, F, Santos, S

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Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice von Keller, Annika, Westenberger, Ana, Sobrido, Maria J, García-Murias, Maria, Domingo, Aloysius, Sears, Renee L, Lemos, Roberta R, Ordoñez-Ugalde, Andres, Nicolas, Gael, da Cunha, José E Gomes, Rushing, Elisabeth J, Hugelshofer, Michael, Wurnig, Moritz C, Kaech, Andres, Reimann, Regina, Lohmann, Katja, Dobričić, Valerija, Carracedo, Angel, Petrović, Igor, Miyasaki, Janis M, Abakumova, Irina, Mäe, Maarja Andaloussi, Raschperger, Elisabeth, Zatz, Mayana, Zschiedrich, Katja, Klepper, Jörg, Spiteri, Elizabeth, Prieto, Jose M, Navas, Inmaculada, Preuss, Michael, Dering, Carmen, Janković, Milena, Paucar, Martin, Svenningsson, Per, Saliminejad, Kioomars, Khorshid, Hamid R K, Novaković, Ivana, Aguzzi, Adriano, Boss, Andreas, Le Ber, Isabelle, Defer, Gilles, Hannequin, Didier, Kostić, Vladimir S, Campion, Dominique, Geschwind, Daniel H, Coppola, Giovanni, Betsholtz, Christer, Klein, Christine, Oliveira, Joao R M

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Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity von Tangye, Stuart G., Abel, Laurent, Al-Muhsen, Salah, Aiuti, Alessandro, Al-Muhsen, Saleh, Al-Mulla, Fahd, Anderson, Mark S., Andreakos, Evangelos, Novelli, Antonio, Arias, Andrés A., Feldman, Hagit Baris, Belot, Alexandre, Biggs, Catherine M., Bousfiha, Ahmed A., Brodin, Petter, Christodoulou, John, Condino-Neto, Antonio, Dalgard, Clifton L., Espinosa-Padilla, Sara, Fellay, Jacques, Flores, Carlos, Franco, José Luis, Froidure, Antoine, Haerynck, Filomeen, Halwani, Rabih, Hammarström, Lennart, Henrickson, Sarah E., Hsieh, Elena W.Y., Itan, Yuval, Karamitros, Timokratis, Lau, Yu-Lung, Mansouri, Davood, Meyts, Isabelle, Mogensen, Trine H., Morio, Tomohiro, Ng, Lisa F.P., Notarangelo, Luigi D., Novelli, Giuseppe, Okada, Satoshi, Ozcelik, Tayfun, Pan-Hammarström, Qiang, Perez de Diego, Rebeca, Prando, Carolina, Pujol, Aurora, Renia, Laurent, Resnick, Igor, Rodríguez-Gallego, Carlos, Sancho-Shimizu, Vanessa, Seppänen, Mikko R.J., Shcherbina, Anna, Snow, Andrew L., Soler-Palacín, Pere, Spaan, András N., Tancevski, Ivan, Tangye, Stuart G., Tayoun, Ahmad Abou, Temel, Sehime G., Turvey, Stuart E., Uddin, Mohammed J., Vinh, Donald C., Zatz, Mayana, Okamoto, Keisuke, Pelin, David S., Pesole, Graziano, van de Beek, Diederik, Colobran, Roger, Wauters, Joost, Su, Helen C., Casanova, Jean-Laurent

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