Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress von Port, Jennifer, Muthalagu, Nathiya, Raja, Meera, Ceteci, Fatih, Monteverde, Tiziana, Kruspig, Björn, Hedley, Ann, Kalna, Gabriela, Lilla, Sergio, Neilson, Lisa, Brucoli, Martina, Gyuraszova, Katarina, Tait-Mulder, Jacqueline, Mezna, Mokdad, Svambaryte, Silvija, Bryson, Amy, Sumpton, David, McVie, Allan, Nixon, Colin, Drysdale, Martin, Esumi, Hiroyasu, Murray, Graeme I, Sansom, Owen J, Zanivan, Sara R, Murphy, Daniel J

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Formate induces a metabolic switch in nucleotide and energy metabolism von Oizel, Kristell, Tait-Mulder, Jacqueline, Fernandez-de-Cossio-Diaz, Jorge, Pietzke, Matthias, Brunton, Holly, Lilla, Sergio, Dhayade, Sandeep, Athineos, Dimitri, Blanco, Giovanny Rodriguez, Sumpton, David, Mackay, Gillian M., Blyth, Karen, Zanivan, Sara R., Meiser, Johannes, Vazquez, Alexei

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Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion von Marco, Sergi, Neilson, Matthew, Moore, Madeleine, Perez-Garcia, Arantxa, Hall, Holly, Mitchell, Louise, Lilla, Sergio, Blanco, Giovani R., Hedley, Ann, Zanivan, Sara, Norman, Jim C.

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Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics von Mann, Matthias, Geiger, Tamar, Wisniewski, Jacek R, Cox, Juergen, Zanivan, Sara, Kruger, Marcus, Ishihama, Yasushi

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Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling von Kugeratski, Fernanda G, Atkinson, Samuel J, Neilson, Lisa J, Lilla, Sergio, Knight, John R P, Serneels, Jens, Juin, Amelie, Ismail, Shehab, Bryant, David M, Markert, Elke K, Machesky, Laura M, Mazzone, Massimiliano, Sansom, Owen J, Zanivan, Sara

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Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels von Novo, David, Heath, Nikki, Mitchell, Louise, Caligiuri, Giuseppina, MacFarlane, Amanda, Reijmer, Dide, Charlton, Laura, Knight, John, Calka, Monika, McGhee, Ewan, Dornier, Emmanuel, Sumpton, David, Mason, Susan, Echard, Arnaud, Klinkert, Kerstin, Secklehner, Judith, Kruiswijk, Flore, Vousden, Karen, Macpherson, Iain R., Blyth, Karen, Bailey, Peter, Yin, Huabing, Carlin, Leo M., Morton, Jennifer, Zanivan, Sara, Norman, Jim C.

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eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′UTR von Wilczynska, Ania, Gillen, Sarah L., Schmidt, Tobias, Meijer, Hedda A., Jukes-Jones, Rebekah, Langlais, Claudia, Kopra, Kari, Lu, Wei-Ting, Godfrey, Jack D., Hawley, Benjamin R., Hodge, Kelly, Zanivan, Sara, Cain, Kelvin, Le Quesne, John, Bushell, Martin

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In Vivo SILAC-Based Proteomics Reveals Phosphoproteome Changes during Mouse Skin Carcinogenesis von Zanivan, Sara, Meves, Alexander, Behrendt, Kristina, Schoof, Erwin M., Neilson, Lisa J., Cox, Jürgen, Tang, Hao R., Kalna, Gabriela, van Ree, Janine H., van Deursen, Jan M., Trempus, Carol S., Machesky, Laura M., Linding, Rune, Wickström, Sara A., Fässler, Reinhard, Mann, Matthias

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Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy von Subramaniam, Gunasekaran, Schleicher, Katharina, Kovanich, Duangnapa, Zerio, Anna, Folkmanaite, Milda, Chao, Ying-Chi, Surdo, Nicoletta C., Koschinski, Andreas, Hu, Jianshu, Scholten, Arjen, Heck, Albert J.R., Ercu, Maria, Sholokh, Anastasiia, Chan Park, Kyung, Klussmann, Enno, Meraviglia, Viviana, Bellin, Milena, Zanivan, Sara, Hester, Svenja, Mohammed, Shabaz, Zaccolo, Manuela

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Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability[S] von Patella, Francesca, Schug, Zachary T., Persi, Erez, Neilson, Lisa J., Erami, Zahra, Avanzato, Daniele, Maione, Federica, Hernandez-Fernaud, Juan R., Mackay, Gillian, Zheng, Liang, Reid, Steven, Frezza, Christian, Giraudo, Enrico, Fiorio Pla, Alessandra, Anderson, Kurt, Ruppin, Eytan, Gottlieb, Eyal, Zanivan, Sara

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Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity von Hernandez-Fernaud, Juan R., Ruengeler, Elena, Casazza, Andrea, Neilson, Lisa J., Pulleine, Ellie, Santi, Alice, Ismail, Shehab, Lilla, Sergio, Dhayade, Sandeep, MacPherson, Iain R., McNeish, Iain, Ennis, Darren, Ali, Hala, Kugeratski, Fernanda G., Al Khamici, Heba, van den Biggelaar, Maartje, van den Berghe, Peter V.E., Cloix, Catherine, McDonald, Laura, Millan, David, Hoyle, Aoisha, Kuchnio, Anna, Carmeliet, Peter, Valenzuela, Stella M., Blyth, Karen, Yin, Huabing, Mazzone, Massimiliano, Norman, Jim C., Zanivan, Sara

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Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function von Santi, Alice, Kay, Emily J, Neilson, Lisa J, McGarry, Lynn, Lilla, Sergio, Mullin, Margaret, Paul, Nikki R, Fercoq, Frédéric, Koulouras, Grigorios, Rodriguez Blanco, Giovanny, Athineos, Dimitris, Mason, Susan, Hughes, Mark, Thomson, Gemma, Kieffer, Yann, Nixon, Colin, Blyth, Karen, Mechta-Grigoriou, Fatima, Carlin, Leo M, Zanivan, Sara

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MASTL promotes cell contractility and motility through kinase-independent signaling von Taskinen, Maria Emilia, Närvä, Elisa, Conway, James R W, Hinojosa, Laura Soto, Lilla, Sergio, Mai, Anja, De Franceschi, Nicola, Elo, Laura L, Grosse, Robert, Zanivan, Sara, Norman, Jim C, Ivaska, Johanna

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Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy von Subramaniam, Gunasekaran, Schleicher, Katharina, Kovanich, Duangnapa, Zerio, Anna, Folkmanaite, Milda, Chao, Ying-Chi, Surdo, Nicoletta C, Koschinski, Andreas, Hu, Jianshu, Scholten, Arjen, Heck, Albert J R, Ercu, Maria, Sholokh, Anastasiia, Chan Park, Kyung, Klussmann, Enno, Meraviglia, Viviana, Bellin, Milena, Zanivan, Sara, Hester, Svenja, Mohammed, Shabaz, Zaccolo, Manuela

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CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors von Whitelaw, Jamie A., Lilla, Sergio, Paul, Nikki R., Fort, Loic, Zanivan, Sara, Machesky, Laura M.

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The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis von Clarke, Cassie J., Berg, Tracy J., Birch, Joanna, Ennis, Darren, Mitchell, Louise, Cloix, Catherine, Campbell, Andrew, Sumpton, David, Nixon, Colin, Campbell, Kirsteen, Bridgeman, Victoria L., Vermeulen, Peter B., Foo, Shane, Kostaras, Eleftherios, Jones, J. Louise, Haywood, Linda, Pulleine, Ellie, Yin, Huabing, Strathdee, Douglas, Sansom, Owen, Blyth, Karen, McNeish, Iain, Zanivan, Sara, Reynolds, Andrew R., Norman, Jim C.

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Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix von Kay, Emily J., Paterson, Karla, Riera-Domingo, Carla, Sumpton, David, Däbritz, J. Henry M., Tardito, Saverio, Boldrini, Claudia, Hernandez-Fernaud, Juan R., Athineos, Dimitris, Dhayade, Sandeep, Stepanova, Ekaterina, Gjerga, Enio, Neilson, Lisa J., Lilla, Sergio, Hedley, Ann, Koulouras, Grigorios, McGregor, Grace, Jamieson, Craig, Johnson, Radia Marie, Park, Morag, Kirschner, Kristina, Miller, Crispin, Kamphorst, Jurre J., Loayza-Puch, Fabricio, Saez-Rodriguez, Julio, Mazzone, Massimiliano, Blyth, Karen, Zagnoni, Michele, Zanivan, Sara

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Abstract AP18: PRO-INVASIVE TUMOUR-STROMA INTERACTIONS: ROLE OF THE SECRETED OXIDOREDUCTASE CLIC3 von Hernandez-Fernaud, Juan R, Ruengeler, Elena, Neilson, Lisa J, Ismail, Shehab, McNeish, Iain, Atkinson, Samuel, Lilla, Sergio, Santi, Alice, Valenzuela, Stella M, Blyth, Karen, Yin, Huabing, Mazzone, Massimiliano, Norman, Jim C, Zanivan, Sara

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Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor von Azimifar, S Babak, Böttcher, Ralph T, Zanivan, Sara, Grashoff, Carsten, Krüger, Marcus, Legate, Kyle R, Mann, Matthias, Fässler, Reinhard

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Abstract PR11: Increased matrix stiffness induces CCN1 mediated upregulation of N-Cadherin in endothelial cells: Implications for cancer cell metastasis von Reid, Steven, Serneels, Jens, Neilson, Lisa J., Henze, Anne-Theres, Hernández-Fernaud, Juan R., Adams, Ralf H., Blyth, Karen, Mazzone, Massimiliano, Zanivan, Sara

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