Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes von Sands, Arthur T, Zambrowicz, Brian P, Rosenstock, Julio, Lapuerta, Pablo, Bode, Bruce W, Garg, Satish K, Buse, John B, Banks, Phillip, Heptulla, Rubina, Rendell, Marc, Cefalu, William T, Strumph, Paul

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Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor von Lapuerta, Pablo, Zambrowicz, Brian, Strumph, Paul, Sands, Arthur

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Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome von Kulke, Matthew H, Hörsch, Dieter, Caplin, Martyn E, Anthony, Lowell B, Bergsland, Emily, Öberg, Kjell, Welin, Staffan, Warner, Richard R P, Lombard-Bohas, Catherine, Kunz, Pamela L, Grande, Enrique, Valle, Juan W, Fleming, Douglas, Lapuerta, Pablo, Banks, Phillip, Jackson, Shanna, Zambrowicz, Brian, Sands, Arthur T, Pavel, Marianne

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A mouse knockout library for secreted and transmembrane proteins von de Sauvage, Frederic J, Tang, Tracy, Li, Li, Tang, Jerry, Li, Yun, Lin, Wei Yu, Martin, Flavius, Grant, Deanna, Solloway, Mark, Parker, Leon, Ye, Weilan, Forrest, William, Ghilardi, Nico, Oravecz, Tamas, Platt, Kenneth A, Rice, Dennis S, Hansen, Gwenn M, Abuin, Alejandro, Eberhart, Derek E, Godowski, Paul, Holt, Kathleen H, Peterson, Andrew, Zambrowicz, Brian P

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C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice von Atanasio, Amanda, Decman, Vilma, White, Derek, Ramos, Meg, Ikiz, Burcin, Lee, Hoi-Ching, Siao, Chia-Jen, Brydges, Susannah, LaRosa, Elizabeth, Bai, Yu, Fury, Wen, Burfeind, Patricia, Zamfirova, Ralica, Warshaw, Gregg, Orengo, Jamie, Oyejide, Adelekan, Fralish, Michael, Auerbach, Wojtek, Poueymirou, William, Freudenberg, Jan, Gong, Guochun, Zambrowicz, Brian, Valenzuela, David, Yancopoulos, George, Murphy, Andrew, Thurston, Gavin, Lai, Ka-Man Venus

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Lrp5 functions in bone to regulate bone mass von Cui, Yajun, Niziolek, Paul J, MacDonald, Bryan T, Zylstra, Cassandra R, Alenina, Natalia, Robinson, Daniel R, Zhong, Zhendong, Matthes, Susann, Jacobsen, Christina M, Conlon, Ronald A, Brommage, Robert, Liu, Qingyun, Mseeh, Faika, Powell, David R, Yang, Qi M, Zambrowicz, Brian, Gerrits, Han, Gossen, Jan A, He, Xi, Bader, Michael, Williams, Bart O, Warman, Matthew L, Robling, Alexander G

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Knockouts model the 100 best-selling drugs-will they model the next 100? von Zambrowicz, Brian P, Sands, Arthur T

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Effects of LX4211, a Dual SGLT1/SGLT2 Inhibitor, Plus Sitagliptin on Postprandial Active GLP-1 and Glycemic Control in Type 2 Diabetes von Zambrowicz, Brian, PhD, Ding, Zhi-Ming, MD, PhD, Ogbaa, Ike, MD, Frazier, Kenny, BS, Banks, Phillip, MS, Turnage, Anne, BA, Freiman, Joel, MD, Smith, Melinda, BS, Ruff, Dennis, MD, Sands, Arthur, MD, PhD, Powell, David, MD

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A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood-Brain Barrier Crossing Therapeutic Strategies von Chim, Shek Man, Howell, Kristen, Kokkosis, Alexandros, Zambrowicz, Brian, Karalis, Katia, Pavlopoulos, Elias

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Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation von Kim, Janice J, Wang, Huaqing, Terc, Joshua D, Zambrowicz, Brian, Yang, Qi M, Khan, Waliul I

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Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL) von Lee, E-Chiang, Desai, Urvi, Gololobov, Gennady, Hong, Seokjoo, Feng, Xiao, Yu, Xuan-Chuan, Gay, Jason, Wilganowski, Nat, Gao, Cuihua, Du, Ling-Ling, Chen, Joan, Hu, Yi, Zhao, Sharon, Kirkpatrick, Laura, Schneider, Matthias, Zambrowicz, Brian P., Landes, Greg, Powell, David R., Sonnenburg, William K.

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Improved glycemic control in mice lacking Sglt1 and Sglt2 von Powell, David R, DaCosta, Christopher M, Gay, Jason, Ding, Zhi-Ming, Smith, Melinda, Greer, Jennifer, Doree, Deon, Jeter-Jones, Sabrina, Mseeh, Faika, Rodriguez, Lawrence A, Harris, Angela, Buhring, Lindsey, Platt, Kenneth A, Vogel, Peter, Brommage, Robert, Shadoan, Melanie K, Sands, Arthur T, Zambrowicz, Brian

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Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5 von Latuszek, Adrianna, Liu, Yashu, Olsen, Olav, Foster, Randi, Cao, Marc, Lovric, Irena, Yuan, Ming, Liu, Nina, Chen, Henry, Zhang, Qian, Xiao, Hui, Springer, Carola, Ehrlich, George, Kamat, Vishal, Rafique, Ashique, Hu, Ying, Krueger, Pamela, Huang, Tammy, Poueymirou, William, Babb, Robert, Rosconi, Michael P, Retter, Marc W, Chen, Gang, Morton, Lori, Zambrowicz, Brian, Cao, Jingtai, Romano, Carmelo, Olson, William C

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Keratinocyte migration in the developing eyelid requires LIMK2 von Rice, Dennis S, Hansen, Gwenn M, Liu, Feng, Crist, Mike J, Newhouse, Matthew M, Potter, David, Xu, Nianhua, Abuin, Alejandro, Vogel, Peter J, Zambrowicz, Brian P

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Effects of LX4211, a Dual Sodium-Dependent Glucose Cotransporters 1 and 2 Inhibitor, on Postprandial Glucose, Insulin, Glucagon-like Peptide 1, and Peptide Tyrosine Tyrosine in a D... von Zambrowicz, Brian, PhD, Ogbaa, Ike, MD, Frazier, Kenny, BS, Banks, Phillip, MS, Turnage, Anne, BA, Freiman, Joel, MD, Boehm, Kristi A., MS, Ruff, Dennis, MD, Powell, David, MD, Sands, Arthur, MD, PhD

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GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4 von Sonnenburg, William K., Yu, Daiguan, Lee, E-Chiang, Xiong, Wei, Gololobov, Gennady, Key, Billie, Gay, Jason, Wilganowski, Nat, Hu, Yi, Zhao, Sharon, Schneider, Matthias, Ding, Zhi-Ming, Zambrowicz, Brian P., Landes, Greg, Powell, David R., Desai, Urvi

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Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice von Desai, Urvi, Lee, E. Chiang, Chung, Kyu, Gao, Cuihua, Gay, Jason, Key, Billie, Hansen, Gwenn, Machajewski, Dennis, Platt, Kenneth A, Sands, Arthur T, Schneider, Matthias, Van Sligtenhorst, Isaac, Suwanichkul, Adisak, Vogel, Peter, Wilganowski, Nat, Wingert, June, Zambrowicz, Brian P, Landes, Greg, Powell, David R

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Wnk1 Kinase Deficiency Lowers Blood Pressure in Mice: A Gene-Trap Screen to Identify Potential Targets for Therapeutic Intervention von Zambrowicz, Brian P., Abuin, Alejandro, Ramirez-Solis, Ramiro, Richter, Lizabeth J., Piggott, James, BeltrandelRio, Hector, Buxton, Eric C., Edwards, Joel, Finch, Rick A., Friddle, Carl J., Gupta, Anupma, Hansen, Gwenn, Hu, Yi, Huang, Wenhu, Jaing, Crystal, Key, Billie Wayne, Kipp, Peter, Kohlhauff, Buckley, Ma, Zhi-Qing, Markesich, Diane, Payne, Robert, Potter, David G., Qian, Ny, Shaw, Joseph, Schrick, Jeff, Shi, Zheng-Zheng, Sparks, Mary Jean, Van Sligtenhorst, Isaac, Vogel, Peter, Walke, Wade, Xu, Nianhua, Zhu, Qichao, Person, Christophe, Sands, Arthur T.

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Genetic deletion of Mst1 alters T cell function and protects against autoimmunity von Salojin, Konstantin V, Hamman, Brian D, Chang, Wei Chun, Jhaver, Kanchan G, Al-Shami, Amin, Crisostomo, Jeannette, Wilkins, Carrie, Digeorge-Foushee, Ann Marie, Allen, Jason, Patel, Nita, Gopinathan, Suma, Zhou, Julia, Nouraldeen, Amr, Jessop, Theodore C, Bagdanoff, Jeffrey T, Augeri, David J, Read, Robert, Vogel, Peter, Swaffield, Jonathan, Wilson, Alan, Platt, Kenneth A, Carson, Kenneth G, Main, Alan, Zambrowicz, Brian P, Oravecz, Tamas

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High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes von Brommage, Robert, Liu, Jeff, Hansen, Gwenn M, Kirkpatrick, Laura L, Potter, David G, Sands, Arthur T, Zambrowicz, Brian, Powell, David R, Vogel, Peter

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